CK068_MOUSE
ID CK068_MOUSE Reviewed; 298 AA.
AC Q8VD62; E9QNR6; Q6LCE3;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2018, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=UPF0696 protein C11orf68 homolog;
DE AltName: Full=Basophilic leukemia-expressed protein Bles03;
DE AltName: Full=Protein WF-3;
GN Name=Bles03;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 33-298 (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-298 (ISOFORM 1).
RC STRAIN=CD-1 X ICR;
RA Sugihara T.;
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q8VD62-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8VD62-1; Sequence=VSP_059973, VSP_059974;
CC -!- SIMILARITY: Belongs to the UPF0696 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24516.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AC122861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017542; AAH17542.1; -; mRNA.
DR EMBL; BC024516; AAH24516.1; ALT_SEQ; mRNA.
DR EMBL; U64690; AAR00571.1; -; mRNA.
DR CCDS; CCDS29463.2; -. [Q8VD62-2]
DR CCDS; CCDS89308.1; -. [Q8VD62-1]
DR RefSeq; NP_001243444.1; NM_001256515.1. [Q8VD62-1]
DR RefSeq; NP_598910.2; NM_134149.2. [Q8VD62-2]
DR AlphaFoldDB; Q8VD62; -.
DR SMR; Q8VD62; -.
DR BioGRID; 223223; 65.
DR IntAct; Q8VD62; 65.
DR STRING; 10090.ENSMUSP00000125651; -.
DR iPTMnet; Q8VD62; -.
DR PhosphoSitePlus; Q8VD62; -.
DR EPD; Q8VD62; -.
DR jPOST; Q8VD62; -.
DR MaxQB; Q8VD62; -.
DR PaxDb; Q8VD62; -.
DR PRIDE; Q8VD62; -.
DR ProteomicsDB; 283504; -. [Q8VD62-2]
DR ProteomicsDB; 357875; -.
DR Antibodypedia; 51800; 44 antibodies from 11 providers.
DR DNASU; 107242; -.
DR Ensembl; ENSMUST00000054477; ENSMUSP00000158508; ENSMUSG00000047423. [Q8VD62-1]
DR Ensembl; ENSMUST00000159759; ENSMUSP00000125651; ENSMUSG00000047423. [Q8VD62-2]
DR GeneID; 107242; -.
DR KEGG; mmu:107242; -.
DR MGI; MGI:2147598; AI837181.
DR VEuPathDB; HostDB:ENSMUSG00000047423; -.
DR eggNOG; ENOG502QRQJ; Eukaryota.
DR GeneTree; ENSGT00390000011640; -.
DR HOGENOM; CLU_051869_1_0_1; -.
DR InParanoid; Q8VD62; -.
DR OMA; TGKWLMH; -.
DR OrthoDB; 1023014at2759; -.
DR PhylomeDB; Q8VD62; -.
DR TreeFam; TF331797; -.
DR BioGRID-ORCS; 107242; 2 hits in 71 CRISPR screens.
DR ChiTaRS; AI837181; mouse.
DR PRO; PR:Q8VD62; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VD62; protein.
DR Bgee; ENSMUSG00000047423; Expressed in embryonic brain and 238 other tissues.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR015034; Bles03.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR PANTHER; PTHR31977; PTHR31977; 1.
DR Pfam; PF08939; DUF1917; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..298
FT /note="UPF0696 protein C11orf68 homolog"
FT /id="PRO_0000228118"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 47..181
FT /note="RMEPNEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELD
FT AWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYTPNSGDVQGLQAAWEALQTSGRPI
FT TPGTLRQLAITHHVLSGKWLIHLS -> SSLTTGWNQMRSWKRKTLQVAGRMASLLSTW
FT LQRPWQPIWTPGWYLMPVPHLPQSWMPGWPSTHHLKLLAMGTQVHPTLNLWAGLQPMGR
FT VTPPTQGMYKGCRRPGRLCRPVGDPSHQVPCASWPSPTMCSPASG (in isoform
FT 1)"
FT /id="VSP_059973"
FT VAR_SEQ 182..298
FT /note="Missing (in isoform 1)"
FT /id="VSP_059974"
FT CONFLICT 79
FT /note="A -> G (in Ref. 3; AAR00571)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 31846 MW; 7B523E307FD228D3 CRC64;
MAAAAAAVAG AGRGGGGGGG GGGAADPGQE RSRARSWVGA ERSEGRRMEP NEELEEEDSP
GGREDGFTAE HLAAEAMAAD MDPWLVFDAR TTPATELDAW LAKYPPSQVT RYGDPGSPNS
EPVGWIAAYG QGYTPNSGDV QGLQAAWEAL QTSGRPITPG TLRQLAITHH VLSGKWLIHL
SPGFKLDHAW AGIARAVVEG RLQVAKVSPR AKEGGRQVIC VYTDDFTDRL GVLEADSAIR
AAGIKCLLTY KPDVYTYLGI YRANRWHLCP TLYESRFQLG GNTRGSRVLD RANNVELT
