CK068_RAT
ID CK068_RAT Reviewed; 292 AA.
AC Q566Q8; A0A0H2UHS1; Q8K436;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2018, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=UPF0696 protein C11orf68 homolog;
DE AltName: Full=Basophilic leukemia-expressed protein Bles03;
GN Name=Bles03;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-16 (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 224-234, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Lubec G., Chen W.-Q.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 229-292 (ISOFORM 1).
RC STRAIN=Wistar; TISSUE=Leukemia;
RA Heneberg P., Draber P.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q566Q8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q566Q8-2; Sequence=VSP_059975, VSP_059976;
CC -!- SIMILARITY: Belongs to the UPF0696 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH93387.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AC109096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473953; EDM12488.1; -; Genomic_DNA.
DR EMBL; BC093387; AAH93387.1; ALT_SEQ; mRNA.
DR EMBL; AF502571; AAN02287.1; -; mRNA.
DR RefSeq; NP_001019404.2; NM_001024233.2. [Q566Q8-1]
DR RefSeq; NP_001230463.1; NM_001243534.1. [Q566Q8-2]
DR AlphaFoldDB; Q566Q8; -.
DR SMR; Q566Q8; -.
DR BioGRID; 251761; 1.
DR STRING; 10116.ENSRNOP00000027869; -.
DR PhosphoSitePlus; Q566Q8; -.
DR jPOST; Q566Q8; -.
DR PaxDb; Q566Q8; -.
DR PeptideAtlas; Q566Q8; -.
DR PRIDE; Q566Q8; -.
DR Ensembl; ENSRNOT00000027869; ENSRNOP00000027869; ENSRNOG00000020551. [Q566Q8-1]
DR GeneID; 266609; -.
DR KEGG; rno:266609; -.
DR CTD; 266609; -.
DR RGD; 628612; Bles03.
DR eggNOG; ENOG502QRQJ; Eukaryota.
DR GeneTree; ENSGT00390000011640; -.
DR HOGENOM; CLU_051869_1_0_1; -.
DR InParanoid; Q566Q8; -.
DR OMA; TGKWLMH; -.
DR OrthoDB; 1023014at2759; -.
DR PhylomeDB; Q566Q8; -.
DR PRO; PR:Q566Q8; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Proteomes; UP000234681; Chromosome 1.
DR Bgee; ENSRNOG00000020551; Expressed in cerebellum and 19 other tissues.
DR Genevisible; Q566Q8; RN.
DR Gene3D; 3.30.760.10; -; 1.
DR InterPro; IPR015034; Bles03.
DR InterPro; IPR023398; TIF_eIF4e-like.
DR PANTHER; PTHR31977; PTHR31977; 1.
DR Pfam; PF08939; DUF1917; 1.
DR SUPFAM; SSF55418; SSF55418; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Reference proteome.
FT CHAIN 1..292
FT /note="UPF0696 protein C11orf68 homolog"
FT /id="PRO_0000228119"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 41..175
FT /note="RMEPNEELEEEDSPGGREDGFTAEHLAAEAMAADMDPWLVFDARTTPATELD
FT AWLAKYPPSQVTRYGDPGSPNSEPVGWIAAYGQGYTPNSGDVQGLQAAWEALQTSGRPI
FT TPGTLRQLAITHHVLSGKWLIHLA -> SSLTTGWNQMKSWKRRTLQVVVRMASLLSTW
FT LQRPWQLTWTPGWYLMPVLHLPQSWMPGWPSTHHLKLLAMGTQVHPTLNLWAGLQPMGR
FT VTPPIQGMYKGCRQPGRLCRPVGDPSHQVPCASWPSPTMCSPASG (in isoform
FT 2)"
FT /id="VSP_059975"
FT VAR_SEQ 176..292
FT /note="Missing (in isoform 2)"
FT /id="VSP_059976"
SQ SEQUENCE 292 AA; 31443 MW; 1DFB244E791FFAAC CRC64;
MAAAAAAVAG AGRGGGGGAD PGQERSRARS WVGAERSEGR RMEPNEELEE EDSPGGREDG
FTAEHLAAEA MAADMDPWLV FDARTTPATE LDAWLAKYPP SQVTRYGDPG SPNSEPVGWI
AAYGQGYTPN SGDVQGLQAA WEALQTSGRP ITPGTLRQLA ITHHVLSGKW LIHLAPGFKL
DHAWAGIARA VVEGRLQVAK VSPRAKEGGR QVICVYTDDF TDRLGVLEAD SAIRAAGIKC
LLTYKPDVYT YLGIYRANRW HLCPTLYESR FQLGGNARGS RVLDRANNVE LT
