CK071_HUMAN
ID CK071_HUMAN Reviewed; 123 AA.
AC Q6IPW1; Q6IAD3; Q9NXX1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized protein C11orf71;
GN Name=C11orf71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Adipose tissue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6IPW1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6IPW1-2; Sequence=VSP_022711;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR457222; CAG33503.1; -; mRNA.
DR EMBL; AK000017; BAA90886.1; -; mRNA.
DR EMBL; BC009041; AAH09041.1; -; mRNA.
DR EMBL; BC071695; AAH71695.1; -; mRNA.
DR CCDS; CCDS76479.1; -. [Q6IPW1-1]
DR CCDS; CCDS8369.2; -. [Q6IPW1-2]
DR RefSeq; NP_001258491.1; NM_001271562.1. [Q6IPW1-1]
DR RefSeq; NP_061894.2; NM_019021.3. [Q6IPW1-2]
DR AlphaFoldDB; Q6IPW1; -.
DR SMR; Q6IPW1; -.
DR BioGRID; 119990; 10.
DR IntAct; Q6IPW1; 3.
DR STRING; 9606.ENSP00000325508; -.
DR iPTMnet; Q6IPW1; -.
DR PhosphoSitePlus; Q6IPW1; -.
DR BioMuta; C11orf71; -.
DR MassIVE; Q6IPW1; -.
DR PaxDb; Q6IPW1; -.
DR PeptideAtlas; Q6IPW1; -.
DR PRIDE; Q6IPW1; -.
DR Antibodypedia; 54330; 41 antibodies from 6 providers.
DR DNASU; 54494; -.
DR Ensembl; ENST00000325636.8; ENSP00000325508.4; ENSG00000180425.11. [Q6IPW1-2]
DR Ensembl; ENST00000623205.2; ENSP00000492536.1; ENSG00000180425.11. [Q6IPW1-1]
DR GeneID; 54494; -.
DR KEGG; hsa:54494; -.
DR MANE-Select; ENST00000623205.2; ENSP00000492536.1; NM_001271562.2; NP_001258491.1.
DR UCSC; uc001pot.3; human. [Q6IPW1-1]
DR CTD; 54494; -.
DR GeneCards; C11orf71; -.
DR HGNC; HGNC:25937; C11orf71.
DR HPA; ENSG00000180425; Tissue enriched (testis).
DR neXtProt; NX_Q6IPW1; -.
DR OpenTargets; ENSG00000180425; -.
DR PharmGKB; PA144596490; -.
DR VEuPathDB; HostDB:ENSG00000180425; -.
DR eggNOG; ENOG502TDVE; Eukaryota.
DR GeneTree; ENSGT00390000007962; -.
DR HOGENOM; CLU_149706_0_0_1; -.
DR InParanoid; Q6IPW1; -.
DR OMA; LRWCSTC; -.
DR OrthoDB; 1619340at2759; -.
DR PhylomeDB; Q6IPW1; -.
DR TreeFam; TF337033; -.
DR PathwayCommons; Q6IPW1; -.
DR SignaLink; Q6IPW1; -.
DR BioGRID-ORCS; 54494; 9 hits in 1055 CRISPR screens.
DR ChiTaRS; C11orf71; human.
DR GenomeRNAi; 54494; -.
DR Pharos; Q6IPW1; Tdark.
DR PRO; PR:Q6IPW1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IPW1; protein.
DR Bgee; ENSG00000180425; Expressed in sperm and 184 other tissues.
DR ExpressionAtlas; Q6IPW1; baseline and differential.
DR Genevisible; Q6IPW1; HS.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR031487; DUF4687.
DR PANTHER; PTHR16445; PTHR16445; 1.
DR Pfam; PF15747; DUF4687; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..123
FT /note="Uncharacterized protein C11orf71"
FT /id="PRO_0000274325"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 115..123
FT /note="GVIAARISV -> VTTWTLKLSESATPDLRWCSTCSHSNIFEILVI (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022711"
FT CONFLICT 30
FT /note="A -> V (in Ref. 1; CAG33503)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 123 AA; 13249 MW; 4B076F3B26670EFC CRC64;
MALNNVSLSS GDQRSRVAYR SSHGDLRPRA SALAMVSGDG FLVSRPEAIH LGPRQAVRPS
VRAESRRVDG GGRSPREPDG RGRSRQARFS PYPIPAVEPD LLRSVLQQRL IALGGVIAAR
ISV
