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ACHA_CHICK
ID   ACHA_CHICK              Reviewed;         456 AA.
AC   P09479;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Acetylcholine receptor subunit alpha;
DE   Flags: Precursor;
GN   Name=CHRNA1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=White leghorn; TISSUE=Brain;
RX   PubMed=3267226; DOI=10.1002/j.1460-2075.1988.tb02852.x;
RA   Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.;
RT   "Genes expressed in the brain define three distinct neuronal nicotinic
RT   acetylcholine receptors.";
RL   EMBO J. 7:595-601(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 1-12.
RX   PubMed=3821734; DOI=10.1128/mcb.7.2.951-955.1987;
RA   Klarsfeld A., Daubas P., Bourachot B., Changeux J.-P.;
RT   "A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit
RT   gene confers tissue specificity and developmental control of expression in
RT   transfected cells.";
RL   Mol. Cell. Biol. 7:951-955(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 180-227 AND 260-333.
RX   PubMed=6327170; DOI=10.1101/sqb.1983.048.01.011;
RA   Ballivet M., Nef P., Stalder R., Fulpius B.;
RT   "Genomic sequences encoding the alpha-subunit of acetylcholine receptor are
RT   conserved in evolution.";
RL   Cold Spring Harb. Symp. Quant. Biol. 48:83-87(1983).
RN   [4]
RP   PROTEIN SEQUENCE OF 21-44.
RX   PubMed=3860855; DOI=10.1073/pnas.82.15.5208;
RA   Conti-Tronconi B.M., Dunn S.M.J., Barnard E.A., Dolly J.O., Lai F.A.,
RA   Ray N., Raftery M.A.;
RT   "Brain and muscle nicotinic acetylcholine receptors are different but
RT   homologous proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:5208-5212(1985).
CC   -!- FUNCTION: Upon acetylcholine binding, the AChR responds by an extensive
CC       change in conformation that affects all subunits and leads to opening
CC       of an ion-conducting channel across the plasma membrane.
CC       {ECO:0000250|UniProtKB:P02708}.
CC   -!- SUBUNIT: One of the alpha chains that assemble within the acetylcholine
CC       receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma
CC       or epsilon chains. {ECO:0000250|UniProtKB:P02708}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC       {ECO:0000250|UniProtKB:P02708}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P02708}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X07330; CAA30282.1; -; Genomic_DNA.
DR   EMBL; X07331; CAA30282.1; JOINED; Genomic_DNA.
DR   EMBL; X12434; CAA30282.1; JOINED; Genomic_DNA.
DR   EMBL; X12435; CAA30282.1; JOINED; Genomic_DNA.
DR   EMBL; X12436; CAA30282.1; JOINED; Genomic_DNA.
DR   EMBL; X07335; CAA30282.1; JOINED; Genomic_DNA.
DR   EMBL; AJ250359; CAB59624.1; -; mRNA.
DR   EMBL; AF051909; AAC06012.1; -; Genomic_DNA.
DR   EMBL; M14808; AAA48565.1; -; Genomic_DNA.
DR   EMBL; M14809; AAA48564.1; -; Genomic_DNA.
DR   PIR; I50149; I50149.
DR   PIR; I50150; I50150.
DR   PIR; S00376; ACCHAN.
DR   RefSeq; NP_990147.1; NM_204816.1.
DR   AlphaFoldDB; P09479; -.
DR   SMR; P09479; -.
DR   ComplexPortal; CPX-254; Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma.
DR   STRING; 9031.ENSGALP00000015122; -.
DR   PaxDb; P09479; -.
DR   GeneID; 395608; -.
DR   KEGG; gga:395608; -.
DR   CTD; 1134; -.
DR   VEuPathDB; HostDB:geneid_395608; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   HOGENOM; CLU_018074_2_1_1; -.
DR   InParanoid; P09479; -.
DR   OrthoDB; 381858at2759; -.
DR   PhylomeDB; P09479; -.
DR   PRO; PR:P09479; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005892; C:acetylcholine-gated channel complex; IC:ComplexPortal.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR   GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR   GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IC:ComplexPortal.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.20.58.390; -; 2.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 2.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW   Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:3860855"
FT   CHAIN           21..456
FT                   /note="Acetylcholine receptor subunit alpha"
FT                   /id="PRO_0000000308"
FT   TOPO_DOM        21..229
FT                   /note="Extracellular"
FT   TRANSMEM        230..254
FT                   /note="Helical"
FT   TRANSMEM        262..280
FT                   /note="Helical"
FT   TRANSMEM        296..315
FT                   /note="Helical"
FT   TOPO_DOM        316..427
FT                   /note="Cytoplasmic"
FT   TRANSMEM        428..446
FT                   /note="Helical"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        147..161
FT   DISULFID        211..212
FT                   /note="Associated with receptor activation"
FT   CONFLICT        33
FT                   /note="E -> D (in Ref. 4; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   456 AA;  52183 MW;  0B31B6EABD7B4D42 CRC64;
     MELCRVLLLI FSAAGPALCY EHETRLVDDL FREYSKVVRP VENHRDAVVV TVGLQLIQLI
     NVDEVNQIVT TNVRLKQQWT DINLKWNPDD YGGVKQIRIP SDDIWRPDLV LYNNADGDFA
     IVKYTKVLLE HTGKITWTPP AIFKSYCEII VTYFPFDQQN CSMKLGTWTY DGTMVVINPE
     SDRPDLSNFM ESGEWVMKDY RGWKHWVYYA CCPDTPYLDI TYHFLMQRLP LYFIVNVIIP
     CLLFSFLTGF VFYLPTDSGE KMTLSISVLL SLTVFLLVIV ELIPSTSSAV PLIGKYMLFT
     MVFVIASIII TVIVINTHHR SPSTHTMPPW VRKIFIDTIP NIMFFSTMKR PSRDKPDKKI
     FAEDIDISEI SGKQGPVPVN FYSPLTKNPD VKNAIEGIKY IAETMKSDQE SSNAADEWKF
     VAMVLDHLLL VIFMLVCIIG TLAVFAGRLI ELNQQG
 
 
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