CK087_HUMAN
ID CK087_HUMAN Reviewed; 197 AA.
AC Q6NUJ2; B4E169;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Uncharacterized protein C11orf87;
DE Flags: Precursor;
GN Name=C11orf87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6NUJ2; P48745: CCN3; NbExp=3; IntAct=EBI-6660291, EBI-3904822;
CC Q6NUJ2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-6660291, EBI-3867333;
CC Q6NUJ2; O76011: KRT34; NbExp=3; IntAct=EBI-6660291, EBI-1047093;
CC Q6NUJ2; Q6A162: KRT40; NbExp=3; IntAct=EBI-6660291, EBI-10171697;
CC Q6NUJ2; P78385: KRT83; NbExp=3; IntAct=EBI-6660291, EBI-10221390;
CC Q6NUJ2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-6660291, EBI-11959885;
CC Q6NUJ2; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-6660291, EBI-10172150;
CC Q6NUJ2; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-6660291, EBI-10171774;
CC Q6NUJ2; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-6660291, EBI-10172052;
CC Q6NUJ2; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-6660291, EBI-11953334;
CC Q6NUJ2; Q8IUB9: KRTAP19-1; NbExp=3; IntAct=EBI-6660291, EBI-12811111;
CC Q6NUJ2; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-6660291, EBI-14065470;
CC Q6NUJ2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-6660291, EBI-3958099;
CC Q6NUJ2; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-6660291, EBI-945833;
CC Q6NUJ2; Q93062: RBPMS; NbExp=3; IntAct=EBI-6660291, EBI-740322;
CC Q6NUJ2; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-6660291, EBI-740343;
CC Q6NUJ2; Q16348: SLC15A2; NbExp=3; IntAct=EBI-6660291, EBI-12806032;
CC Q6NUJ2; Q63HR2: TNS2; NbExp=3; IntAct=EBI-6660291, EBI-949753;
CC Q6NUJ2; Q15654: TRIP6; NbExp=3; IntAct=EBI-6660291, EBI-742327;
CC Q6NUJ2; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-6660291, EBI-12040603;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK303693; BAG64681.1; -; mRNA.
DR EMBL; AP000775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67125.1; -; Genomic_DNA.
DR EMBL; BC068577; AAH68577.1; -; mRNA.
DR CCDS; CCDS31672.1; -.
DR RefSeq; NP_997528.2; NM_207645.3.
DR RefSeq; XP_011541120.1; XM_011542818.2.
DR AlphaFoldDB; Q6NUJ2; -.
DR SMR; Q6NUJ2; -.
DR BioGRID; 134460; 66.
DR IntAct; Q6NUJ2; 20.
DR STRING; 9606.ENSP00000331581; -.
DR GlyGen; Q6NUJ2; 1 site.
DR PhosphoSitePlus; Q6NUJ2; -.
DR BioMuta; C11orf87; -.
DR DMDM; 296434450; -.
DR MassIVE; Q6NUJ2; -.
DR PaxDb; Q6NUJ2; -.
DR PeptideAtlas; Q6NUJ2; -.
DR PRIDE; Q6NUJ2; -.
DR ProteomicsDB; 66683; -.
DR Antibodypedia; 32002; 25 antibodies from 14 providers.
DR DNASU; 399947; -.
DR Ensembl; ENST00000327419.7; ENSP00000331581.6; ENSG00000185742.7.
DR GeneID; 399947; -.
DR KEGG; hsa:399947; -.
DR MANE-Select; ENST00000327419.7; ENSP00000331581.6; NM_207645.4; NP_997528.2.
DR UCSC; uc010rwb.3; human.
DR CTD; 399947; -.
DR GeneCards; C11orf87; -.
DR HGNC; HGNC:33788; C11orf87.
DR HPA; ENSG00000185742; Tissue enriched (brain).
DR neXtProt; NX_Q6NUJ2; -.
DR OpenTargets; ENSG00000185742; -.
DR PharmGKB; PA162377822; -.
DR VEuPathDB; HostDB:ENSG00000185742; -.
DR eggNOG; ENOG502S981; Eukaryota.
DR GeneTree; ENSGT00390000012905; -.
DR HOGENOM; CLU_074982_0_0_1; -.
DR InParanoid; Q6NUJ2; -.
DR OMA; HIHKRKM; -.
DR OrthoDB; 1485645at2759; -.
DR PhylomeDB; Q6NUJ2; -.
DR TreeFam; TF336990; -.
DR PathwayCommons; Q6NUJ2; -.
DR SignaLink; Q6NUJ2; -.
DR BioGRID-ORCS; 399947; 13 hits in 1048 CRISPR screens.
DR ChiTaRS; C11orf87; human.
DR GenomeRNAi; 399947; -.
DR Pharos; Q6NUJ2; Tdark.
DR PRO; PR:Q6NUJ2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6NUJ2; protein.
DR Bgee; ENSG00000185742; Expressed in endothelial cell and 77 other tissues.
DR ExpressionAtlas; Q6NUJ2; baseline and differential.
DR Genevisible; Q6NUJ2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037670; C11orf87.
DR PANTHER; PTHR31870; PTHR31870; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..197
FT /note="Uncharacterized protein C11orf87"
FT /id="PRO_0000320195"
FT TOPO_DOM 24..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 94..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 70
FT /note="L -> V (in Ref. 4; AAH68577)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 20623 MW; 128A6464B36C8FA5 CRC64;
MSARAPKELR LALPPCLLNR TFASPNASGS GNTGARGPGA VGSGTCITQV GQQLFQSFSS
TLVLIVLVTL IFCLIVLSLS TFHIHKRRMK KRKMQRAQEE YERDHCSGSR GGGGLPRPGR
QAPTHAKETR LERQPRDSPF CAPSNASSLS SSSPGLPCQG PCAPPPPPPA SSPQGAHAAS
SCLDTAGEGL LQTVVLS
