CK096_HUMAN
ID CK096_HUMAN Reviewed; 435 AA.
AC Q7Z7L8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Uncharacterized protein C11orf96;
DE AltName: Full=Protein Ag2 homolog;
GN Name=C11orf96; Synonyms=AG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-435.
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399 AND SER-425, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-368, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
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DR EMBL; AC087521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052560; AAH52560.1; -; mRNA.
DR RefSeq; NP_001138505.1; NM_001145033.1.
DR AlphaFoldDB; Q7Z7L8; -.
DR BioGRID; 132431; 1.
DR STRING; 9606.ENSP00000479976; -.
DR GlyGen; Q7Z7L8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z7L8; -.
DR PhosphoSitePlus; Q7Z7L8; -.
DR BioMuta; C11orf96; -.
DR DMDM; 229463005; -.
DR jPOST; Q7Z7L8; -.
DR MassIVE; Q7Z7L8; -.
DR PaxDb; Q7Z7L8; -.
DR PeptideAtlas; Q7Z7L8; -.
DR PRIDE; Q7Z7L8; -.
DR ProteomicsDB; 69563; -.
DR Antibodypedia; 50640; 6 antibodies from 5 providers.
DR DNASU; 387763; -.
DR Ensembl; ENST00000339446.3; ENSP00000498932.1; ENSG00000187479.8.
DR GeneID; 387763; -.
DR KEGG; hsa:387763; -.
DR UCSC; uc058aps.1; human.
DR CTD; 387763; -.
DR DisGeNET; 387763; -.
DR GeneCards; C11orf96; -.
DR HGNC; HGNC:38675; C11orf96.
DR HPA; ENSG00000187479; Tissue enhanced (fallopian tube, ovary).
DR neXtProt; NX_Q7Z7L8; -.
DR OpenTargets; ENSG00000187479; -.
DR PharmGKB; PA165543281; -.
DR VEuPathDB; HostDB:ENSG00000187479; -.
DR eggNOG; ENOG502S2E8; Eukaryota.
DR GeneTree; ENSGT00390000016821; -.
DR HOGENOM; CLU_635451_0_0_1; -.
DR InParanoid; Q7Z7L8; -.
DR OrthoDB; 1607032at2759; -.
DR PhylomeDB; Q7Z7L8; -.
DR TreeFam; TF337679; -.
DR PathwayCommons; Q7Z7L8; -.
DR SignaLink; Q7Z7L8; -.
DR BioGRID-ORCS; 387763; 8 hits in 307 CRISPR screens.
DR ChiTaRS; C11orf96; human.
DR GenomeRNAi; 387763; -.
DR Pharos; Q7Z7L8; Tdark.
DR PRO; PR:Q7Z7L8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q7Z7L8; protein.
DR Bgee; ENSG00000187479; Expressed in vena cava and 180 other tissues.
DR ExpressionAtlas; Q7Z7L8; baseline and differential.
DR Genevisible; Q7Z7L8; HS.
DR InterPro; IPR031521; DUF4695.
DR PANTHER; PTHR40250; PTHR40250; 1.
DR Pfam; PF15766; DUF4695; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..435
FT /note="Uncharacterized protein C11orf96"
FT /id="PRO_0000320641"
FT REGION 147..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..258
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 368
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UPL5"
FT MOD_RES 399
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UPL5"
FT MOD_RES 425
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 431
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A8IHN8"
FT VARIANT 26
FT /note="T -> A (in dbSNP:rs1973717)"
FT /id="VAR_039242"
FT VARIANT 47
FT /note="S -> P (in dbSNP:rs12797684)"
FT /id="VAR_039243"
FT VARIANT 110
FT /note="R -> S (in dbSNP:rs12796438)"
FT /id="VAR_039244"
FT VARIANT 144
FT /note="R -> C (in dbSNP:rs12796667)"
FT /id="VAR_039245"
FT VARIANT 151
FT /note="F -> S (in dbSNP:rs12798337)"
FT /id="VAR_039246"
FT VARIANT 352
FT /note="P -> S (in dbSNP:rs2434483)"
FT /id="VAR_039247"
SQ SEQUENCE 435 AA; 46114 MW; F536980973B14478 CRC64;
MGNKQPQKVT VPTGTALQGV VLIVSTLHQP GGWICGKDPC CSLRPLSNSV QNALACKSKQ
DYQAGILFKT RAFISRDCGS DAAEDSASKG ETYTLTLEHK GAGEGDLRPR GQPGWCRLGD
PRRDSARPVA AIEGPCPGAA RASRVLRGRG FSRNPRGRGL PSGAGWRGAG GAGEGAVTFP
ERRGDVRRKG AGRARFKWHS LSSELRAVWA AAGYISREPG RRGADGDSSG GERLGARRNS
APRAPCPPTG PPARPPSRGA PARAREGRRH PAADLDPPPG EPPAAASRGA PAQRPPSESP
GAPPPGPADA GGAMAAKPGE LMGICSSYQA VMPHFVCLAD EFPQPVRPAK LPKGRGRLRR
PRQSRFKTQP VTFDEIQEVE EEGVSPMEEE KAKKSFLQSL ECLRRSTQSL SLQREQLSSC
KLRNSLDSSD SDSAL
