CK097_MOUSE
ID CK097_MOUSE Reviewed; 121 AA.
AC Q9DAE7;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized protein C11orf97 homolog {ECO:0000305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RX PubMed=27914912; DOI=10.1016/j.ydbio.2016.11.019;
RA Stauber M., Weidemann M., Dittrich-Breiholz O., Lobschat K., Alten L.,
RA Mai M., Beckers A., Kracht M., Gossler A.;
RT "Identification of FOXJ1 effectors during ciliogenesis in the foetal
RT respiratory epithelium and embryonic left-right organiser of the mouse.";
RL Dev. Biol. 423:170-188(2017).
RN [6]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=28666954; DOI=10.1016/j.ydbio.2017.06.027;
RA Stauber M., Boldt K., Wrede C., Weidemann M., Kellner M.,
RA Schuster-Gossler K., Kuehnel M.P., Hegermann J., Ueffing M., Gossler A.;
RT "1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the
RT mouse but not essential for motile ciliogenesis.";
RL Dev. Biol. 429:186-199(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000269|PubMed:27914912, ECO:0000269|PubMed:28666954}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in tissues containing
CC motile cilia (PubMed:28666954, PubMed:27914912). Also expressed in non-
CC motile ciliated adult olfactory bulbs (PubMed:28666954).
CC {ECO:0000269|PubMed:27914912, ECO:0000269|PubMed:28666954}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing fetal lung epithelium,
CC embryonic ventral node and developing brain (at protein level)
CC (PubMed:28666954, PubMed:27914912). {ECO:0000269|PubMed:27914912,
CC ECO:0000269|PubMed:28666954}.
CC -!- INDUCTION: Expression is activated by FOXJ1 and NOTO.
CC {ECO:0000269|PubMed:27914912, ECO:0000269|PubMed:28666954}.
CC -!- DISRUPTION PHENOTYPE: Mice exhibited no impaired function of motile
CC cilia or non-motile cilia. {ECO:0000269|PubMed:28666954}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK005890; BAB24304.1; -; mRNA.
DR EMBL; CT030247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466522; EDL25002.1; -; Genomic_DNA.
DR EMBL; CH466522; EDL25003.1; -; Genomic_DNA.
DR EMBL; BC092535; AAH92535.1; -; mRNA.
DR CCDS; CCDS40536.1; -.
DR RefSeq; NP_083582.2; NM_029306.3.
DR AlphaFoldDB; Q9DAE7; -.
DR STRING; 10090.ENSMUSP00000049826; -.
DR PaxDb; Q9DAE7; -.
DR PRIDE; Q9DAE7; -.
DR DNASU; 69325; -.
DR Ensembl; ENSMUST00000060330; ENSMUSP00000049826; ENSMUSG00000031927.
DR Ensembl; ENSMUST00000188350; ENSMUSP00000139796; ENSMUSG00000031927.
DR GeneID; 69325; -.
DR KEGG; mmu:69325; -.
DR UCSC; uc009oey.2; mouse.
DR MGI; MGI:1916575; 1700012B09Rik.
DR VEuPathDB; HostDB:ENSMUSG00000031927; -.
DR eggNOG; ENOG502SAWP; Eukaryota.
DR GeneTree; ENSGT00520000058823; -.
DR HOGENOM; CLU_2009274_0_0_1; -.
DR InParanoid; Q9DAE7; -.
DR OMA; CHIKNPA; -.
DR OrthoDB; 1584194at2759; -.
DR BioGRID-ORCS; 69325; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9DAE7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9DAE7; protein.
DR Bgee; ENSMUSG00000031927; Expressed in olfactory epithelium and 55 other tissues.
DR ExpressionAtlas; Q9DAE7; baseline and differential.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR040429; C11orf97-like.
DR PANTHER; PTHR38326; PTHR38326; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..121
FT /note="Uncharacterized protein C11orf97 homolog"
FT /id="PRO_0000440044"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 121 AA; 13565 MW; F0F7B414B6D6516A CRC64;
MRRQEALAGT ASEAGREGEQ PRPAGLGCRT RAEPGGPQES RQQWKTFLYC EPHKRIKEVL
EEELSIKRDE CHVKSPPTVA LDGIWSIRRN LPVGGTISGQ QSRNSSLPQA KYYSRHGGLR
R
