ID   CK2B_DICDI              Reviewed;         268 AA.
AC   Q54PF1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Casein kinase II subunit beta;
DE            Short=CK II beta;
GN   Name=csnk2b; ORFNames=DDB_G0284601;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the
CC       kinase complex regulates the basal catalytic activity of the alpha
CC       subunit a constitutively active serine/threonine-protein kinase that
CC       phosphorylates a large number of substrates containing acidic residues
CC       C-terminal to the phosphorylated serine or threonine.
CC       {ECO:0000250|UniProtKB:P67870}.
CC   -!- SUBUNIT: Casein kinase II/CK2 is a tetramer composed of two alpha
CC       subunit and two beta subunits. {ECO:0000250|UniProtKB:P67870}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000069; EAL65139.1; -; Genomic_DNA.
DR   RefSeq; XP_638493.1; XM_633401.1.
DR   AlphaFoldDB; Q54PF1; -.
DR   SMR; Q54PF1; -.
DR   STRING; 44689.DDB0216346; -.
DR   PaxDb; Q54PF1; -.
DR   EnsemblProtists; EAL65139; EAL65139; DDB_G0284601.
DR   GeneID; 8624673; -.
DR   KEGG; ddi:DDB_G0284601; -.
DR   dictyBase; DDB_G0284601; csnk2b.
DR   eggNOG; KOG3092; Eukaryota.
DR   HOGENOM; CLU_034027_3_2_1; -.
DR   InParanoid; Q54PF1; -.
DR   OMA; WIHWFCK; -.
DR   PhylomeDB; Q54PF1; -.
DR   Reactome; R-DDI-2514853; Condensation of Prometaphase Chromosomes.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-DDI-8934903; Receptor Mediated Mitophagy.
DR   Reactome; R-DDI-8948751; Regulation of PTEN stability and activity.
DR   PRO; PR:Q54PF1; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0005956; C:protein kinase CK2 complex; IBA:GO_Central.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..268
FT                   /note="Casein kinase II subunit beta"
FT                   /id="PRO_0000330664"
FT   REGION          222..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  31019 MW;  6315E2FD14F6CD9B CRC64;
     MDRKYKDTSS EEEDSLNEDE MAWIPWYCNL KGNEFFATID EDYINDDFNL TGLSSLVQFY
     DSALGIILDS DPDDPLSEDQ QEALERSADI LYGLIHARYI LTPKGLAHMH EKFKKAEFGR
     CPRVFCQNQP VLPVGLADMQ GVDTVKVYCP RCNDIFNPKY RRHSHIDGAY FGTTFPHLLL
     ITYPELIPTK PPQQYIPKIY GFKIHKSARE RQLQIQQKKN SLSNNNQNNQ NNNINNNNNN
     NNNNNNNNNN NNNNQQNNNN QQNNNTNK