ID   CK2N1_BOVIN             Reviewed;          78 AA.
AC   A7MBG3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 1;
GN   Name=CAMK2N1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal brain;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By
CC       similarity). Plays a role in the maintenance of long-term retrieval-
CC       induced memory in response to contextual fear (By similarity).
CC       Modulates blood pressure and vascular reactivity via regulation of
CC       CAMK2 activity in addition to regulation of left ventricular mass (By
CC       similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via
CC       acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways,
CC       thereby regulating ventricular remodeling and cardiac rhythm post-
CC       myocardial infarction (By similarity). Negatively effects insulin
CC       sensitivity and promotes lipid formation in adipose tissues independent
CC       of CAMK2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6QWF9,
CC       ECO:0000250|UniProtKB:Q9JI15}.
CC   -!- SUBUNIT: Interacts with CAMK2B; the presence of Ca(2+)/calmodulin
CC       increases the interaction but is not essential (By similarity).
CC       Interacts with CAMK2A; this interaction requires CAMK2A activation by
CC       Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q9JI15}.
CC   -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell
CC       projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic
CC       density {ECO:0000250|UniProtKB:Q6QWF9}.
CC   -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
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DR   EMBL; BC151544; AAI51545.1; -; mRNA.
DR   RefSeq; NP_001107992.1; NM_001114520.1.
DR   AlphaFoldDB; A7MBG3; -.
DR   STRING; 9913.ENSBTAP00000012064; -.
DR   PaxDb; A7MBG3; -.
DR   Ensembl; ENSBTAT00000012064; ENSBTAP00000012064; ENSBTAG00000009156.
DR   GeneID; 616227; -.
DR   KEGG; bta:616227; -.
DR   CTD; 55450; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009156; -.
DR   VGNC; VGNC:26723; CAMK2N1.
DR   eggNOG; ENOG502S6QW; Eukaryota.
DR   GeneTree; ENSGT00390000004940; -.
DR   HOGENOM; CLU_197183_0_0_1; -.
DR   InParanoid; A7MBG3; -.
DR   OMA; NEQKNGT; -.
DR   OrthoDB; 1637105at2759; -.
DR   TreeFam; TF333175; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000009156; Expressed in occipital lobe and 99 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0008427; F:calcium-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0007616; P:long-term memory; ISS:UniProtKB.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR   InterPro; IPR026779; Camk2n.
DR   PANTHER; PTHR31007; PTHR31007; 1.
DR   Pfam; PF15170; CaM-KIIN; 1.
PE   3: Inferred from homology;
KW   Cell projection; Protein kinase inhibitor; Reference proteome; Synapse.
FT   CHAIN           1..78
FT                   /note="Calcium/calmodulin-dependent protein kinase II
FT                   inhibitor 1"
FT                   /id="PRO_0000338392"
FT   REGION          41..68
FT                   /note="CAMK2 inhibitory domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8539 MW;  6199735DA10B7764 CRC64;
     MSEVLPYGDE KLSPYGDGGD VGQVFSCRLQ DTNNFFGAGQ NKRPPKLGQI GRSKRVVIED
     DRIDDVLKNM TDKAPPGV