ID   ACHA_ELEEL              Reviewed;          24 AA.
AC   P09688;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Acetylcholine receptor subunit alpha;
DE   Flags: Fragment;
GN   Name=chrna1;
OS   Electrophorus electricus (Electric eel) (Gymnotus electricus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC   Gymnotoidei; Gymnotidae; Electrophorus.
OX   NCBI_TaxID=8005;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6959131; DOI=10.1073/pnas.79.21.6489;
RA   Conti-Tronconi B.M., Hunkapiller M.W., Lindstrom J.M., Raftery M.A.;
RT   "Subunit structure of the acetylcholine receptor from Electrophorus
RT   electricus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:6489-6493(1982).
CC   -!- FUNCTION: Upon acetylcholine binding, the AChR responds by an extensive
CC       change in conformation that affects all subunits and leads to opening
CC       of an ion-conducting channel across the plasma membrane.
CC       {ECO:0000250|UniProtKB:P02708}.
CC   -!- SUBUNIT: One of the alpha chains that assemble within the acetylcholine
CC       receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma
CC       or epsilon chains. {ECO:0000250|UniProtKB:P02708}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC       {ECO:0000250|UniProtKB:P02708}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P02708}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A27262; A27262.
DR   AlphaFoldDB; P09688; -.
DR   STRING; 8005.ENSEEEP00000009993; -.
DR   Proteomes; UP000314983; Unassembled WGS sequence.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   SUPFAM; SSF63712; SSF63712; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Reference proteome; Synapse; Transmembrane; Transport.
FT   CHAIN           1..>24
FT                   /note="Acetylcholine receptor subunit alpha"
FT                   /id="PRO_0000076974"
FT   NON_TER         24
SQ   SEQUENCE   24 AA;  2802 MW;  3FE05AFB6B4983AE CRC64;
     SEDETRLVKN LFSGYNKVVR PVNH