CK2N1_HUMAN
ID CK2N1_HUMAN Reviewed; 78 AA.
AC Q7Z7J9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 1;
DE AltName: Full=CaMKII inhibitory protein alpha;
DE Short=CaMKIIN-alpha;
GN Name=CAMK2N1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP RETRACTED PAPER.
RC TISSUE=Bone marrow stroma;
RX PubMed=18305109; DOI=10.1074/jbc.m800436200;
RA Wang C., Li N., Liu X., Zheng Y., Cao X.;
RT "A novel endogenous human CaMKII inhibitory protein suppresses tumor growth
RT by inducing cell cycle arrest via p27 stabilization.";
RL J. Biol. Chem. 283:11565-11574(2008).
RN [2]
RP RETRACTION NOTICE OF PUBMED:18305109.
RX PubMed=34237910; DOI=10.1016/j.jbc.2021.100765;
RA Wang C., Li N., Liu X., Zheng Y., Cao X.;
RL J. Biol. Chem. 296:100765-100765(2021).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By
CC similarity). Plays a role in the maintenance of long-term retrieval-
CC induced memory in response to contextual fear (By similarity).
CC Modulates blood pressure and vascular reactivity via regulation of
CC CAMK2 activity in addition to regulation of left ventricular mass (By
CC similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via
CC acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways,
CC thereby regulating ventricular remodeling and cardiac rhythm post-
CC myocardial infarction (By similarity). Negatively effects insulin
CC sensitivity and promotes lipid formation in adipose tissues independent
CC of CAMK2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6QWF9,
CC ECO:0000250|UniProtKB:Q9JI15}.
CC -!- SUBUNIT: Interacts with CAMK2B; the presence of Ca(2+)/calmodulin
CC increases the interaction but is not essential (By similarity).
CC Interacts with CAMK2A; this interaction requires CAMK2A activation by
CC Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q9JI15}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell
CC projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic
CC density {ECO:0000250|UniProtKB:Q6QWF9}.
CC -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
CC -!- CAUTION: There was previous evidence showing expression across a broad
CC range of tissues. However this paper was retracted as immunoblot data
CC was viewed as unreliable. {ECO:0000305|PubMed:18305109,
CC ECO:0000305|PubMed:34237910}.
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DR EMBL; AY204901; AAO49802.1; -; mRNA.
DR EMBL; AL391357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW94923.1; -; Genomic_DNA.
DR CCDS; CCDS207.1; -.
DR RefSeq; NP_061054.2; NM_018584.5.
DR AlphaFoldDB; Q7Z7J9; -.
DR BioGRID; 120671; 4.
DR IntAct; Q7Z7J9; 3.
DR STRING; 9606.ENSP00000364219; -.
DR iPTMnet; Q7Z7J9; -.
DR PhosphoSitePlus; Q7Z7J9; -.
DR BioMuta; CAMK2N1; -.
DR EPD; Q7Z7J9; -.
DR MassIVE; Q7Z7J9; -.
DR MaxQB; Q7Z7J9; -.
DR PaxDb; Q7Z7J9; -.
DR PeptideAtlas; Q7Z7J9; -.
DR PRIDE; Q7Z7J9; -.
DR ProteomicsDB; 69554; -.
DR Antibodypedia; 53235; 77 antibodies from 17 providers.
DR DNASU; 55450; -.
DR Ensembl; ENST00000375078.4; ENSP00000364219.3; ENSG00000162545.6.
DR GeneID; 55450; -.
DR KEGG; hsa:55450; -.
DR MANE-Select; ENST00000375078.4; ENSP00000364219.3; NM_018584.6; NP_061054.2.
DR UCSC; uc001bdh.4; human.
DR CTD; 55450; -.
DR DisGeNET; 55450; -.
DR GeneCards; CAMK2N1; -.
DR HGNC; HGNC:24190; CAMK2N1.
DR HPA; ENSG00000162545; Tissue enhanced (brain).
DR MIM; 614986; gene.
DR neXtProt; NX_Q7Z7J9; -.
DR OpenTargets; ENSG00000162545; -.
DR PharmGKB; PA142672209; -.
DR VEuPathDB; HostDB:ENSG00000162545; -.
DR eggNOG; ENOG502S6QW; Eukaryota.
DR GeneTree; ENSGT00390000004940; -.
DR HOGENOM; CLU_197183_0_0_1; -.
DR InParanoid; Q7Z7J9; -.
DR OMA; NEQKNGT; -.
DR OrthoDB; 1637105at2759; -.
DR PhylomeDB; Q7Z7J9; -.
DR TreeFam; TF333175; -.
DR PathwayCommons; Q7Z7J9; -.
DR SignaLink; Q7Z7J9; -.
DR BioGRID-ORCS; 55450; 19 hits in 1076 CRISPR screens.
DR ChiTaRS; CAMK2N1; human.
DR GenomeRNAi; 55450; -.
DR Pharos; Q7Z7J9; Tbio.
DR PRO; PR:Q7Z7J9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z7J9; protein.
DR Bgee; ENSG00000162545; Expressed in Brodmann (1909) area 46 and 192 other tissues.
DR Genevisible; Q7Z7J9; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR GO; GO:0008427; F:calcium-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007616; P:long-term memory; ISS:UniProtKB.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR InterPro; IPR026779; Camk2n.
DR PANTHER; PTHR31007; PTHR31007; 1.
DR Pfam; PF15170; CaM-KIIN; 1.
PE 3: Inferred from homology;
KW Cell projection; Protein kinase inhibitor; Reference proteome; Synapse.
FT CHAIN 1..78
FT /note="Calcium/calmodulin-dependent protein kinase II
FT inhibitor 1"
FT /id="PRO_0000338393"
FT REGION 41..68
FT /note="CAMK2 inhibitory domain"
SQ SEQUENCE 78 AA; 8553 MW; 31866C5DA10B606F CRC64;
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ NKRPPKLGQI GRSKRVVIED
DRIDDVLKNM TDKAPPGV
