ID   CK2N2_BOVIN             Reviewed;          79 AA.
AC   A5D7T0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 2;
DE   AltName: Full=CaM-KII inhibitory protein;
DE            Short=CaM-KIIN;
GN   Name=CAMK2N2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent and specific cellular inhibitor of CaM-kinase II
CC       (CAMK2) (By similarity). Traps Ca(2+)/calmodulin on CAMK2 (By
CC       similarity). {ECO:0000250|UniProtKB:Q96S95,
CC       ECO:0000250|UniProtKB:Q9Z2N6}.
CC   -!- SUBUNIT: Interacts with CAMK2A and CAMK2B in the presence of
CC       Ca(2+)/calmodulin or after autophosphorylation.
CC       {ECO:0000250|UniProtKB:Q9Z2N6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2N6}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z2N6}. Synapse
CC       {ECO:0000250|UniProtKB:Q78WH7}. Note=Excluded from nucleus when
CC       coexpressed with activated CAMK2. {ECO:0000250|UniProtKB:Q9Z2N6}.
CC   -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
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DR   EMBL; BC140670; AAI40671.1; -; mRNA.
DR   RefSeq; NP_001107986.1; NM_001114514.2.
DR   AlphaFoldDB; A5D7T0; -.
DR   STRING; 9913.ENSBTAP00000007431; -.
DR   BindingDB; A5D7T0; -.
DR   PaxDb; A5D7T0; -.
DR   PRIDE; A5D7T0; -.
DR   Ensembl; ENSBTAT00000007431; ENSBTAP00000007431; ENSBTAG00000005657.
DR   GeneID; 614606; -.
DR   KEGG; bta:614606; -.
DR   CTD; 94032; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005657; -.
DR   VGNC; VGNC:26724; CAMK2N2.
DR   eggNOG; ENOG502S4FG; Eukaryota.
DR   GeneTree; ENSGT00390000004940; -.
DR   HOGENOM; CLU_197183_0_0_1; -.
DR   InParanoid; A5D7T0; -.
DR   OMA; MSEIMPY; -.
DR   TreeFam; TF333175; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000005657; Expressed in floor plate of diencephalon and 50 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR   GO; GO:0008427; F:calcium-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR   InterPro; IPR026779; Camk2n.
DR   PANTHER; PTHR31007; PTHR31007; 1.
DR   Pfam; PF15170; CaM-KIIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein kinase inhibitor; Reference proteome; Synapse.
FT   CHAIN           1..79
FT                   /note="Calcium/calmodulin-dependent protein kinase II
FT                   inhibitor 2"
FT                   /id="PRO_0000327265"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..69
FT                   /note="Inhibitory domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8658 MW;  160C31A092417CEE CRC64;
     MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ IGRAKRVVIE
     DDRIDDVLKG MGEKPPSGV