CK2N2_HUMAN
ID CK2N2_HUMAN Reviewed; 79 AA.
AC Q96S95;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 2;
DE AltName: Full=CaM-KII inhibitory protein;
DE Short=CaM-KIIN;
GN Name=CAMK2N2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Dendritic cell;
RX PubMed=11444830; DOI=10.1006/bbrc.2001.5175;
RA Zhang J., Li N., Yu J., Zhang W., Cao X.;
RT "Molecular cloning and characterization of a novel calcium/calmodulin-
RT dependent protein kinase II inhibitor from human dendritic cells.";
RL Biochem. Biophys. Res. Commun. 285:229-234(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potent and specific cellular inhibitor of CaM-kinase II
CC (CAMK2) (PubMed:11444830). Traps Ca(2+)/calmodulin on CAMK2 (By
CC similarity). {ECO:0000250|UniProtKB:Q9Z2N6,
CC ECO:0000269|PubMed:11444830}.
CC -!- SUBUNIT: Interacts with CAMK2A and CAMK2B in the presence of
CC Ca(2+)/calmodulin or after autophosphorylation.
CC {ECO:0000250|UniProtKB:Q9Z2N6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2N6}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z2N6}. Synapse
CC {ECO:0000250|UniProtKB:Q78WH7}. Note=Excluded from nucleus when
CC coexpressed with activated CAMK2. {ECO:0000250|UniProtKB:Q9Z2N6}.
CC -!- TISSUE SPECIFICITY: Highly Expressed in keyhole limpet hemocyanin-
CC stimulated dendritic cell (DC) and weakly expressed in unstimulated
CC mature and immature DC (PubMed:11444830). Highly expressed in kidney
CC and liver (PubMed:11444830). Moderately expressed in heart, skeletal
CC muscle, and placenta (PubMed:11444830). Weakly expressed in the small
CC intestine (PubMed:11444830). {ECO:0000269|PubMed:11444830}.
CC -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY037149; AAK67630.1; -; mRNA.
DR EMBL; CH471052; EAW78280.1; -; Genomic_DNA.
DR EMBL; BC105077; AAI05078.1; -; mRNA.
DR EMBL; BC105079; AAI05080.1; -; mRNA.
DR CCDS; CCDS3257.1; -.
DR RefSeq; NP_150284.1; NM_033259.2.
DR AlphaFoldDB; Q96S95; -.
DR BioGRID; 125100; 1.
DR IntAct; Q96S95; 2.
DR STRING; 9606.ENSP00000296238; -.
DR GlyGen; Q96S95; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96S95; -.
DR PhosphoSitePlus; Q96S95; -.
DR BioMuta; CAMK2N2; -.
DR EPD; Q96S95; -.
DR MassIVE; Q96S95; -.
DR PaxDb; Q96S95; -.
DR PeptideAtlas; Q96S95; -.
DR PRIDE; Q96S95; -.
DR ProteomicsDB; 78090; -.
DR Antibodypedia; 33806; 62 antibodies from 17 providers.
DR DNASU; 94032; -.
DR Ensembl; ENST00000296238.4; ENSP00000296238.3; ENSG00000163888.4.
DR GeneID; 94032; -.
DR KEGG; hsa:94032; -.
DR MANE-Select; ENST00000296238.4; ENSP00000296238.3; NM_033259.3; NP_150284.1.
DR UCSC; uc003fnj.2; human.
DR CTD; 94032; -.
DR DisGeNET; 94032; -.
DR GeneCards; CAMK2N2; -.
DR HGNC; HGNC:24197; CAMK2N2.
DR HPA; ENSG00000163888; Group enriched (brain, pancreas, pituitary gland).
DR MIM; 608721; gene.
DR neXtProt; NX_Q96S95; -.
DR OpenTargets; ENSG00000163888; -.
DR PharmGKB; PA142672210; -.
DR VEuPathDB; HostDB:ENSG00000163888; -.
DR eggNOG; ENOG502S4FG; Eukaryota.
DR GeneTree; ENSGT00390000004940; -.
DR HOGENOM; CLU_197183_0_0_1; -.
DR InParanoid; Q96S95; -.
DR OMA; MSEIMPY; -.
DR OrthoDB; 1637105at2759; -.
DR PhylomeDB; Q96S95; -.
DR TreeFam; TF333175; -.
DR PathwayCommons; Q96S95; -.
DR SignaLink; Q96S95; -.
DR BioGRID-ORCS; 94032; 11 hits in 1072 CRISPR screens.
DR GenomeRNAi; 94032; -.
DR Pharos; Q96S95; Tbio.
DR PRO; PR:Q96S95; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96S95; protein.
DR Bgee; ENSG00000163888; Expressed in right hemisphere of cerebellum and 109 other tissues.
DR Genevisible; Q96S95; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR GO; GO:0008427; F:calcium-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR InterPro; IPR026779; Camk2n.
DR PANTHER; PTHR31007; PTHR31007; 1.
DR Pfam; PF15170; CaM-KIIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein kinase inhibitor; Reference proteome; Synapse.
FT CHAIN 1..79
FT /note="Calcium/calmodulin-dependent protein kinase II
FT inhibitor 2"
FT /id="PRO_0000327266"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..69
FT /note="Inhibitory domain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8658 MW; 160C31A092417CEE CRC64;
MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ IGRAKRVVIE
DDRIDDVLKG MGEKPPSGV
