CK2N2_MOUSE
ID CK2N2_MOUSE Reviewed; 79 AA.
AC Q78WH7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 2;
DE AltName: Full=CaM-KII inhibitory protein;
DE Short=CaM-KIIN;
GN Name=Camk2n2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=28642476; DOI=10.1038/s41598-017-04355-8;
RA Vigil F.A., Mizuno K., Lucchesi W., Valls-Comamala V., Giese K.P.;
RT "Prevention of long-term memory loss after retrieval by an endogenous
RT CaMKII inhibitor.";
RL Sci. Rep. 7:4040-4040(2017).
CC -!- FUNCTION: Potent and specific cellular inhibitor of CaM-kinase II
CC (CAMK2) (By similarity). Traps Ca(2+)/calmodulin on CAMK2 (By
CC similarity). {ECO:0000250|UniProtKB:Q96S95,
CC ECO:0000250|UniProtKB:Q9Z2N6}.
CC -!- SUBUNIT: Interacts with CAMK2A and CAMK2B in the presence of
CC Ca(2+)/calmodulin or after autophosphorylation.
CC {ECO:0000250|UniProtKB:Q9Z2N6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z2N6}.
CC Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z2N6}. Synapse
CC {ECO:0000269|PubMed:28642476}. Note=Excluded from nucleus when
CC coexpressed with activated CAMK2. {ECO:0000250|UniProtKB:Q9Z2N6}.
CC -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
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DR EMBL; AK013788; BAB28995.1; -; mRNA.
DR CCDS; CCDS49795.1; -.
DR RefSeq; NP_082696.1; NM_028420.2.
DR AlphaFoldDB; Q78WH7; -.
DR STRING; 10090.ENSMUSP00000057368; -.
DR iPTMnet; Q78WH7; -.
DR PhosphoSitePlus; Q78WH7; -.
DR MaxQB; Q78WH7; -.
DR PaxDb; Q78WH7; -.
DR PRIDE; Q78WH7; -.
DR ProteomicsDB; 283857; -.
DR Antibodypedia; 33806; 62 antibodies from 17 providers.
DR Ensembl; ENSMUST00000052939; ENSMUSP00000057368; ENSMUSG00000051146.
DR GeneID; 73047; -.
DR KEGG; mmu:73047; -.
DR UCSC; uc007yqk.2; mouse.
DR CTD; 94032; -.
DR MGI; MGI:1920297; Camk2n2.
DR VEuPathDB; HostDB:ENSMUSG00000051146; -.
DR eggNOG; ENOG502S4FG; Eukaryota.
DR GeneTree; ENSGT00390000004940; -.
DR HOGENOM; CLU_197183_0_0_1; -.
DR InParanoid; Q78WH7; -.
DR OMA; MSEIMPY; -.
DR OrthoDB; 282463at2759; -.
DR PhylomeDB; Q78WH7; -.
DR TreeFam; TF333175; -.
DR BioGRID-ORCS; 73047; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q78WH7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q78WH7; protein.
DR Bgee; ENSMUSG00000051146; Expressed in superior colliculus and 134 other tissues.
DR ExpressionAtlas; Q78WH7; baseline and differential.
DR Genevisible; Q78WH7; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0045202; C:synapse; IDA:UniProtKB.
DR GO; GO:0008427; F:calcium-dependent protein kinase inhibitor activity; IDA:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IBA:GO_Central.
DR InterPro; IPR026779; Camk2n.
DR PANTHER; PTHR31007; PTHR31007; 1.
DR Pfam; PF15170; CaM-KIIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Protein kinase inhibitor; Reference proteome; Synapse.
FT CHAIN 1..79
FT /note="Calcium/calmodulin-dependent protein kinase II
FT inhibitor 2"
FT /id="PRO_0000327267"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..69
FT /note="Inhibitory domain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8628 MW; B34820F5D6417CF3 CRC64;
MSEILPYGED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ IGRAKRVVIE
DDRIDDVLKG MGEKPPSGV
