ID   CK2N2_XENTR             Reviewed;          79 AA.
AC   Q0IHT1;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase II inhibitor 2;
GN   Name=camk2n2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potent and specific cellular inhibitor of CaM-kinase II
CC       (CAMK2). Traps Ca(2+)/calmodulin on CAMK2 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CAMK2N family. {ECO:0000305}.
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DR   EMBL; BC122983; AAI22984.1; -; mRNA.
DR   RefSeq; NP_001165075.1; NM_001171604.1.
DR   AlphaFoldDB; Q0IHT1; -.
DR   STRING; 8364.ENSXETP00000037625; -.
DR   PaxDb; Q0IHT1; -.
DR   DNASU; 780061; -.
DR   Ensembl; ENSXETT00000077767; ENSXETP00000096263; ENSXETG00000038611.
DR   GeneID; 780061; -.
DR   KEGG; xtr:780061; -.
DR   CTD; 94032; -.
DR   eggNOG; ENOG502S4FG; Eukaryota.
DR   HOGENOM; CLU_197183_0_0_1; -.
DR   InParanoid; Q0IHT1; -.
DR   OMA; IGRFIRC; -.
DR   OrthoDB; 1637105at2759; -.
DR   PhylomeDB; Q0IHT1; -.
DR   TreeFam; TF333175; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000038611; Expressed in brain and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR026779; Camk2n.
DR   PANTHER; PTHR31007; PTHR31007; 1.
DR   Pfam; PF15170; CaM-KIIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein kinase inhibitor; Reference proteome.
FT   CHAIN           1..79
FT                   /note="Calcium/calmodulin-dependent protein kinase II
FT                   inhibitor 2"
FT                   /id="PRO_0000327270"
FT   REGION          43..69
FT                   /note="Inhibitory domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   79 AA;  8646 MW;  0F57CAE96EE751C3 CRC64;
     MSEILPYSDE KMGHYGSDGD VGQISFSCRL QDTSSFFGGN QQKRPPKLGQ IGRAKRVVIE
     DDRIDEVLKG VSDKSPSGV