ID   CK5P3_DROME             Reviewed;         509 AA.
AC   Q95SK3;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=CDK5RAP3-like protein {ECO:0000305};
GN   ORFNames=CG30291 {ECO:0000312|FlyBase:FBgn0050291};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Probable regulator of cell proliferation. May regulate CDK5,
CC       NF-kappa-B-mediated gene transcription and p53/TP53 activation.
CC       {ECO:0000250|UniProtKB:Q96JB5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JB5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q96JB5}.
CC   -!- SIMILARITY: Belongs to the CDK5RAP3 family. {ECO:0000305}.
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DR   EMBL; AE013599; AAM68189.1; -; Genomic_DNA.
DR   EMBL; AY060743; AAL28291.1; -; mRNA.
DR   RefSeq; NP_726016.1; NM_166417.2.
DR   AlphaFoldDB; Q95SK3; -.
DR   SMR; Q95SK3; -.
DR   BioGRID; 73099; 5.
DR   DIP; DIP-19388N; -.
DR   STRING; 7227.FBpp0071478; -.
DR   PaxDb; Q95SK3; -.
DR   PRIDE; Q95SK3; -.
DR   DNASU; 246534; -.
DR   EnsemblMetazoa; FBtr0071549; FBpp0071478; FBgn0050291.
DR   GeneID; 246534; -.
DR   KEGG; dme:Dmel_CG30291; -.
DR   UCSC; CG30291-RA; d. melanogaster.
DR   FlyBase; FBgn0050291; CG30291.
DR   VEuPathDB; VectorBase:FBgn0050291; -.
DR   eggNOG; KOG2607; Eukaryota.
DR   GeneTree; ENSGT00390000000713; -.
DR   HOGENOM; CLU_025645_1_0_1; -.
DR   InParanoid; Q95SK3; -.
DR   OMA; PGVRKQM; -.
DR   OrthoDB; 619606at2759; -.
DR   PhylomeDB; Q95SK3; -.
DR   BioGRID-ORCS; 246534; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 246534; -.
DR   PRO; PR:Q95SK3; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0050291; Expressed in spermathecum and 29 other tissues.
DR   Genevisible; Q95SK3; DM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   InterPro; IPR008491; CDK5RAP3.
DR   PANTHER; PTHR14894; PTHR14894; 1.
DR   Pfam; PF05600; DUF773; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..509
FT                   /note="CDK5RAP3-like protein"
FT                   /id="PRO_0000220521"
SQ   SEQUENCE   509 AA;  57742 MW;  282581365CEA8778 CRC64;
     MNESEIPIDI HTLKLQDWLI SRRIVPKNVQ QELREIHRKI SNALQDMPSN EQLIKLLART
     NINYYHVKEI IEILKQTEKD TKSVFGTYGS QRMKDWQEIS RLYEKNATYL AETAQIFVRN
     VNYEIPGVRK QMARLEQQAD ETQKRAHDLN KPESQILADH SALLEQLGVK GDNLHAEFVQ
     VLSGLPELYD KSLVGIANIQ PGIDLYAEVS GNKQVLPILN HLVEFGNTTV YQYIHKEAPL
     AVEEPPIRLN LSEGNASKDD NAVAEIDFGT DDNGGTSSTV SAEIIDYGDF GSGDLPESDG
     GNIDWGIESA PTDAVEINFD IPVEEYGIVV EGTGMDGGTA KGDQAYTLLD SPNYRDRFLD
     EIYELESFLR MRIYELKQLE SSSDIMFSLM DNIATHDGES IWKILVSVEK IIQQTSDKQT
     QHLFQLKHSP KYANMLATKL QQMTKAVEKL RATREALKQL TIELREQRQD LNPVLEELIA
     QTRTLQSHIE KDISKRYKNR VVNLMGGVN