ID   CKB3_CAEEL              Reviewed;         368 AA.
AC   P46560; Q1LZ58;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative choline kinase B3;
DE            EC=2.7.1.32;
GN   Name=ckb-3; ORFNames=B0285.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=12758145; DOI=10.1016/s1570-9639(03)00106-7;
RA   Gee P., Kent C.;
RT   "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning,
RT   expression, purification, and characterization.";
RL   Biochim. Biophys. Acta 1648:33-42(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + choline = ADP + H(+) + phosphocholine;
CC         Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC         EC=2.7.1.32;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z34533; CAA84303.2; -; Genomic_DNA.
DR   EMBL; Z30973; CAA84303.2; JOINED; Genomic_DNA.
DR   EMBL; BK000640; DAA05761.1; -; mRNA.
DR   PIR; T18698; T18698.
DR   RefSeq; NP_497881.2; NM_065480.2.
DR   AlphaFoldDB; P46560; -.
DR   SMR; P46560; -.
DR   BioGRID; 46771; 1.
DR   STRING; 6239.B0285.10; -.
DR   PaxDb; P46560; -.
DR   EnsemblMetazoa; B0285.10.1; B0285.10.1; WBGene00000513.
DR   GeneID; 181905; -.
DR   KEGG; cel:CELE_B0285.10; -.
DR   UCSC; B0285.10; c. elegans.
DR   CTD; 181905; -.
DR   WormBase; B0285.10; CE40595; WBGene00000513; ckb-3.
DR   eggNOG; KOG2686; Eukaryota.
DR   GeneTree; ENSGT00950000182939; -.
DR   HOGENOM; CLU_012712_2_0_1; -.
DR   InParanoid; P46560; -.
DR   OMA; GRMECNK; -.
DR   OrthoDB; 1469912at2759; -.
DR   PhylomeDB; P46560; -.
DR   Reactome; R-CEL-1483191; Synthesis of PC.
DR   Reactome; R-CEL-1483213; Synthesis of PE.
DR   PRO; PR:P46560; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000513; Expressed in embryo and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004103; F:choline kinase activity; IBA:GO_Central.
DR   GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR   GO; GO:0006657; P:CDP-choline pathway; IBA:GO_Central.
DR   GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Lipid biosynthesis; Lipid metabolism; Magnesium;
KW   Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..368
FT                   /note="Putative choline kinase B3"
FT                   /id="PRO_0000206234"
SQ   SEQUENCE   368 AA;  41928 MW;  F8EF0B7998E4DB67 CRC64;
     MKPIEKLFVG NSLDSVAVLQ KALDFGIDFL GDEWKNVNRS EVTVTRILGG QSNHMFHVTS
     STSATSFVLR IHREGQSQFD TDIVNFAIFS ERGLGPKLYG FFEEGRMEEF LPSVTLKLND
     VLNTEISRKI GAAFPKYHAI NVPVSKSRRC FQIMRESLHD YQALGGGDFA IFPTVVTYSE
     HPKSISIKDL LTEIDLLEKW SIDLFENTLV FCHNDLTSSN ILQLNSTGEL VFIDWENASY
     NWRGYDLAMH LSEAAVIRNT CPPGIVINEE LTDNPPNLQA FCEAYVDSEN KIKGLLSSNI
     SSQVNSLIQE CKFFWPITHL FWACFIMKLG LFECNREIKL NAQAREHLAV YFHLRSRSEM
     IYKKLSEN