CKLF1_HUMAN
ID CKLF1_HUMAN Reviewed; 169 AA.
AC Q8IZ96; Q2PPY5; Q6PEV5; Q8IU76; Q8IU83; Q8IU86; Q8IU93; Q8IZ87; Q8IZ88;
AC Q8IZ89; Q8IZ90; Q8IZ91; Q8IZ92; Q8IZ93; Q8IZ94; Q8IZ95; Q96JC2; Q96JC3;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 1;
DE AltName: Full=Chemokine-like factor superfamily member 1;
GN Name=CMTM1; Synonyms=CKLFSF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B; 2; 3; 4; 5; 6; 8; 10; 11; 12;
RP 13; 14; 16 AND 19), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15147728; DOI=10.1016/j.biocel.2003.11.017;
RA Wang L., Wu C., Zheng Y., Qiu X., Wang L., Fan H., Han W., Lv B., Wang Y.,
RA Zhu X., Xu M., Ding P., Cheng S., Zhang Y., Song Q., Ma D.;
RT "Molecular cloning and characterization of chemokine-like factor super
RT family member 1 (CKLFSF1), a novel human gene with at least 23 alternative
RT splicing isoforms in testis tissue.";
RL Int. J. Biochem. Cell Biol. 36:1492-1501(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19).
RA Wang J., Wang L.;
RT "Homo sapiens chemokine-like factor superfamily 1 (CKLFSF1), transcript
RT variant 24.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 24).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=17;
CC Name=1;
CC IsoId=Q8IZ96-1; Sequence=Displayed;
CC Name=1a; Synonyms=17;
CC IsoId=Q8IZ96-2; Sequence=VSP_008229;
CC Name=1b;
CC IsoId=Q8IZ96-3; Sequence=VSP_008229, VSP_008252;
CC Name=2;
CC IsoId=Q8IZ96-4; Sequence=VSP_008251, VSP_008252;
CC Name=3;
CC IsoId=Q8IZ96-5; Sequence=VSP_008234, VSP_008242;
CC Name=4;
CC IsoId=Q8IZ96-6; Sequence=VSP_008237;
CC Name=5;
CC IsoId=Q8IZ96-7; Sequence=VSP_008237, VSP_008251, VSP_008252;
CC Name=6; Synonyms=7;
CC IsoId=Q8IZ96-8; Sequence=VSP_008238, VSP_008249;
CC Name=8; Synonyms=9;
CC IsoId=Q8IZ96-9; Sequence=VSP_008247, VSP_008248;
CC Name=10;
CC IsoId=Q8IZ96-10; Sequence=VSP_008236, VSP_008244;
CC Name=11;
CC IsoId=Q8IZ96-11; Sequence=VSP_008233, VSP_008241;
CC Name=12;
CC IsoId=Q8IZ96-12; Sequence=VSP_008230, VSP_008245, VSP_008246,
CC VSP_008250;
CC Name=13;
CC IsoId=Q8IZ96-13; Sequence=VSP_008235, VSP_008243;
CC Name=14; Synonyms=15;
CC IsoId=Q8IZ96-14; Sequence=VSP_008232, VSP_008240;
CC Name=16;
CC IsoId=Q8IZ96-15; Sequence=VSP_008231, VSP_008239;
CC Name=19; Synonyms=20,21,22,23;
CC IsoId=Q8IZ96-16; Sequence=VSP_008229, VSP_008247, VSP_008248;
CC Name=24;
CC IsoId=Q8IZ96-17; Sequence=VSP_043579;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis.
CC {ECO:0000269|PubMed:12782130, ECO:0000269|PubMed:15147728}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF278576; AAK73015.1; -; mRNA.
DR EMBL; AF278577; AAK73016.1; -; mRNA.
DR EMBL; AY174118; AAN73227.1; -; mRNA.
DR EMBL; AY174119; AAN73228.1; -; mRNA.
DR EMBL; AY174120; AAN73229.1; -; mRNA.
DR EMBL; AY174121; AAN73230.1; -; mRNA.
DR EMBL; AY174122; AAN73231.1; -; mRNA.
DR EMBL; AY174123; AAN73232.1; -; mRNA.
DR EMBL; AY174124; AAN73233.1; -; mRNA.
DR EMBL; AY174125; AAN73234.1; -; mRNA.
DR EMBL; AY174126; AAN73235.1; -; mRNA.
DR EMBL; AY174127; AAN73236.1; -; mRNA.
DR EMBL; AY174128; AAN73237.1; -; mRNA.
DR EMBL; AY174129; AAN73238.1; -; mRNA.
DR EMBL; AY174130; AAN73239.1; -; mRNA.
DR EMBL; AY174131; AAN73240.1; -; mRNA.
DR EMBL; AY174132; AAN73241.1; -; mRNA.
DR EMBL; AY174133; AAN73242.1; -; mRNA.
DR EMBL; AY174134; AAN73243.1; -; mRNA.
DR EMBL; AY174135; AAN73244.1; -; mRNA.
DR EMBL; AY174136; AAN73245.1; -; mRNA.
DR EMBL; AY174137; AAN73246.1; -; mRNA.
DR EMBL; AY174138; AAN73247.1; -; mRNA.
DR EMBL; DQ309766; ABC33727.2; -; mRNA.
DR EMBL; AC010542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83023.1; -; Genomic_DNA.
DR EMBL; BC057852; AAH57852.2; -; mRNA.
DR CCDS; CCDS10810.1; -. [Q8IZ96-5]
DR CCDS; CCDS10811.1; -. [Q8IZ96-6]
DR CCDS; CCDS10812.2; -. [Q8IZ96-17]
DR CCDS; CCDS45503.1; -. [Q8IZ96-1]
DR CCDS; CCDS54019.1; -. [Q8IZ96-4]
DR CCDS; CCDS54020.1; -. [Q8IZ96-7]
DR CCDS; CCDS54021.1; -. [Q8IZ96-15]
DR RefSeq; NP_443725.3; NM_052999.3. [Q8IZ96-17]
DR RefSeq; NP_851785.2; NM_181268.2.
DR RefSeq; NP_851786.1; NM_181269.2. [Q8IZ96-1]
DR RefSeq; NP_851787.1; NM_181270.2. [Q8IZ96-4]
DR RefSeq; NP_851788.1; NM_181271.2. [Q8IZ96-5]
DR RefSeq; NP_851789.1; NM_181272.2. [Q8IZ96-6]
DR RefSeq; NP_851800.1; NM_181283.2. [Q8IZ96-7]
DR RefSeq; NP_851813.1; NM_181296.2. [Q8IZ96-15]
DR AlphaFoldDB; Q8IZ96; -.
DR BioGRID; 125251; 4.
DR IntAct; Q8IZ96; 3.
DR MINT; Q8IZ96; -.
DR STRING; 9606.ENSP00000368814; -.
DR TCDB; 1.A.64.5.5; the plasmolipin (plasmolipin) family.
DR iPTMnet; Q8IZ96; -.
DR PhosphoSitePlus; Q8IZ96; -.
DR BioMuta; CMTM1; -.
DR DMDM; 34921810; -.
DR MassIVE; Q8IZ96; -.
DR MaxQB; Q8IZ96; -.
DR PaxDb; Q8IZ96; -.
DR PeptideAtlas; Q8IZ96; -.
DR PRIDE; Q8IZ96; -.
DR ProteomicsDB; 71291; -. [Q8IZ96-10]
DR ProteomicsDB; 71298; -. [Q8IZ96-17]
DR ProteomicsDB; 71305; -. [Q8IZ96-8]
DR Antibodypedia; 2985; 119 antibodies from 20 providers.
DR DNASU; 113540; -.
DR Ensembl; ENST00000332695.11; ENSP00000331428.7; ENSG00000089505.18. [Q8IZ96-5]
DR Ensembl; ENST00000333001.10; ENSP00000331494.6; ENSG00000089505.18. [Q8IZ96-9]
DR Ensembl; ENST00000336328.10; ENSP00000337119.6; ENSG00000089505.18. [Q8IZ96-6]
DR Ensembl; ENST00000379500.7; ENSP00000368814.2; ENSG00000089505.18. [Q8IZ96-17]
DR Ensembl; ENST00000457188.6; ENSP00000405729.2; ENSG00000089505.18. [Q8IZ96-1]
DR Ensembl; ENST00000528324.5; ENSP00000432398.1; ENSG00000089505.18. [Q8IZ96-4]
DR Ensembl; ENST00000528484.5; ENSP00000437079.1; ENSG00000089505.18. [Q8IZ96-13]
DR Ensembl; ENST00000529386.5; ENSP00000431303.1; ENSG00000089505.18. [Q8IZ96-13]
DR Ensembl; ENST00000531885.5; ENSP00000432687.1; ENSG00000089505.18. [Q8IZ96-7]
DR Ensembl; ENST00000533078.5; ENSP00000432387.1; ENSG00000089505.18. [Q8IZ96-14]
DR Ensembl; ENST00000533666.5; ENSP00000435020.1; ENSG00000089505.18. [Q8IZ96-15]
DR Ensembl; ENST00000533915.5; ENSP00000435755.1; ENSG00000089505.18. [Q8IZ96-9]
DR GeneID; 113540; -.
DR KEGG; hsa:113540; -.
DR MANE-Select; ENST00000379500.7; ENSP00000368814.2; NM_052999.4; NP_443725.3. [Q8IZ96-17]
DR UCSC; uc002epa.5; human. [Q8IZ96-1]
DR CTD; 113540; -.
DR DisGeNET; 113540; -.
DR GeneCards; CMTM1; -.
DR HGNC; HGNC:19172; CMTM1.
DR HPA; ENSG00000089505; Tissue enriched (testis).
DR MIM; 607884; gene.
DR neXtProt; NX_Q8IZ96; -.
DR OpenTargets; ENSG00000089505; -.
DR PharmGKB; PA38811; -.
DR VEuPathDB; HostDB:ENSG00000089505; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000163203; -.
DR HOGENOM; CLU_108546_5_0_1; -.
DR InParanoid; Q8IZ96; -.
DR OMA; TILEACI; -.
DR OrthoDB; 1224540at2759; -.
DR PhylomeDB; Q8IZ96; -.
DR TreeFam; TF338711; -.
DR PathwayCommons; Q8IZ96; -.
DR SignaLink; Q8IZ96; -.
DR BioGRID-ORCS; 113540; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; CMTM1; human.
DR GenomeRNAi; 113540; -.
DR Pharos; Q8IZ96; Tbio.
DR PRO; PR:Q8IZ96; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8IZ96; protein.
DR Bgee; ENSG00000089505; Expressed in left testis and 102 other tissues.
DR ExpressionAtlas; Q8IZ96; baseline and differential.
DR Genevisible; Q8IZ96; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..169
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 1"
FT /id="PRO_0000186097"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 17..135
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 1..26
FT /note="MDPEHAKPESSEAPSGNLKQPETAAA -> MLKILR (in isoform 1a,
FT isoform 1b and isoform 19)"
FT /evidence="ECO:0000303|PubMed:15147728, ECO:0000303|Ref.3"
FT /id="VSP_008229"
FT VAR_SEQ 8..65
FT /note="Missing (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008230"
FT VAR_SEQ 26
FT /note="A -> ALASSGSVVSSVPKAQRNISAKTAPRKHPAVSIRSAQSAAAARPQGS
FT EGTAPSRKATTRPPPKPTLPPPTPSAHTESKLLNEMAIKERVEGRAKVPYKFRDSLKRF
FT SFSPTGMLKILR (in isoform 24)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043579"
FT VAR_SEQ 28..92
FT /note="SLILGALACFIITQANESFITITSLEICIVVFFILIYVLTLHHLLTYLHWPL
FT LDLTNSIITAVFL -> ASSGSVVSSVPKAQRNISAKTAPRKHPAVSIRSAQSAAAARP
FT QGSEGTAPSRILPTVSLQLCSFQ (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008238"
FT VAR_SEQ 28..80
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008237"
FT VAR_SEQ 28..65
FT /note="SLILGALACFIITQANESFITITSLEICIVVFFILIYV -> ASSGSVVSSV
FT PKAQRNISAKTAPRKHPETGPDAPQRPA (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008236"
FT VAR_SEQ 28..38
FT /note="SLILGALACFI -> EADKANMSNFN (in isoform 13)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008235"
FT VAR_SEQ 28..33
FT /note="SLILGA -> EAYNSK (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008233"
FT VAR_SEQ 28..33
FT /note="SLILGA -> ASSGSV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008234"
FT VAR_SEQ 28..32
FT /note="SLILG -> LCSFQ (in isoform 14)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008232"
FT VAR_SEQ 28
FT /note="S -> R (in isoform 16)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008231"
FT VAR_SEQ 29..169
FT /note="Missing (in isoform 16)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008239"
FT VAR_SEQ 33..169
FT /note="Missing (in isoform 14)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008240"
FT VAR_SEQ 34..169
FT /note="Missing (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008241"
FT VAR_SEQ 34..80
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008242"
FT VAR_SEQ 39..169
FT /note="Missing (in isoform 13)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008243"
FT VAR_SEQ 66..169
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008244"
FT VAR_SEQ 77
FT /note="W -> R (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008245"
FT VAR_SEQ 81..103
FT /note="DLTNSIITAVFLSVVAILAMQEK -> AAELSLSHRMPSTGSRQSKYEQL
FT (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008246"
FT VAR_SEQ 81..91
FT /note="DLTNSIITAVF -> NAEYRKQTKQI (in isoform 8 and isoform
FT 19)"
FT /evidence="ECO:0000303|PubMed:15147728, ECO:0000303|Ref.3"
FT /id="VSP_008247"
FT VAR_SEQ 92..169
FT /note="Missing (in isoform 8 and isoform 19)"
FT /evidence="ECO:0000303|PubMed:15147728, ECO:0000303|Ref.3"
FT /id="VSP_008248"
FT VAR_SEQ 93..169
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008249"
FT VAR_SEQ 104..169
FT /note="Missing (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008250"
FT VAR_SEQ 114
FT /note="S -> R (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008251"
FT VAR_SEQ 115..169
FT /note="Missing (in isoform 1b, isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15147728"
FT /id="VSP_008252"
FT VARIANT 10
FT /note="S -> T (in dbSNP:rs16956746)"
FT /id="VAR_053039"
SQ SEQUENCE 169 AA; 18576 MW; 72F3C2E26D738E76 CRC64;
MDPEHAKPES SEAPSGNLKQ PETAAALSLI LGALACFIIT QANESFITIT SLEICIVVFF
ILIYVLTLHH LLTYLHWPLL DLTNSIITAV FLSVVAILAM QEKKRRHLLY VGGSLCLTAV
IVCCIDAFVV TTKMRTNLKR FLGVEVERKL SPAKDAYPET GPDAPQRPA
