CKLF2_HUMAN
ID CKLF2_HUMAN Reviewed; 248 AA.
AC Q8TAZ6; Q5I2A4; Q8N7E5;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 2;
DE AltName: Full=Chemokine-like factor superfamily member 2;
GN Name=CMTM2; Synonyms=CKLFSF2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=15896670; DOI=10.1016/j.biocel.2004.04.028;
RA Shi S., Rui M., Han W., Wang Y., Qiu X., Ding P., Zhang P., Zhu X.,
RA Zhang Y., Gan Q., Ma D.;
RT "CKLFSF2 is highly expressed in testis and can be secreted into the
RT seminiferous tubules.";
RL Int. J. Biochem. Cell Biol. 37:1633-1640(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TAZ6; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-2339374, EBI-2808844;
CC Q8TAZ6; Q6IBD0: CDW52; NbExp=3; IntAct=EBI-2339374, EBI-12011352;
CC Q8TAZ6; P49447: CYB561; NbExp=3; IntAct=EBI-2339374, EBI-8646596;
CC Q8TAZ6; Q6P0A1: FAM180B; NbExp=3; IntAct=EBI-2339374, EBI-17856026;
CC Q8TAZ6; Q9NQG1: MANBAL; NbExp=3; IntAct=EBI-2339374, EBI-3867271;
CC Q8TAZ6; Q0D2K0: NIPAL4; NbExp=3; IntAct=EBI-2339374, EBI-9550165;
CC Q8TAZ6; P30825: SLC7A1; NbExp=3; IntAct=EBI-2339374, EBI-4289564;
CC Q8TAZ6; P0DN84: STRIT1; NbExp=3; IntAct=EBI-2339374, EBI-12200293;
CC Q8TAZ6; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-2339374, EBI-6268651;
CC Q8TAZ6; P48230: TM4SF4; NbExp=3; IntAct=EBI-2339374, EBI-8650934;
CC Q8TAZ6; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-2339374, EBI-7850136;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TAZ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TAZ6-2; Sequence=VSP_047061;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis.
CC {ECO:0000269|PubMed:12782130}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF479260; AAN73038.1; -; mRNA.
DR EMBL; AY862139; AAW51946.1; -; mRNA.
DR EMBL; AK098598; BAC05345.1; -; mRNA.
DR EMBL; AC010542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025354; AAH25354.1; -; mRNA.
DR CCDS; CCDS10814.1; -. [Q8TAZ6-1]
DR CCDS; CCDS56001.1; -. [Q8TAZ6-2]
DR RefSeq; NP_001186246.1; NM_001199317.1. [Q8TAZ6-2]
DR RefSeq; NP_653274.1; NM_144673.2. [Q8TAZ6-1]
DR AlphaFoldDB; Q8TAZ6; -.
DR BioGRID; 126973; 28.
DR IntAct; Q8TAZ6; 13.
DR STRING; 9606.ENSP00000268595; -.
DR iPTMnet; Q8TAZ6; -.
DR PhosphoSitePlus; Q8TAZ6; -.
DR BioMuta; CMTM2; -.
DR DMDM; 34921873; -.
DR MassIVE; Q8TAZ6; -.
DR PaxDb; Q8TAZ6; -.
DR PeptideAtlas; Q8TAZ6; -.
DR PRIDE; Q8TAZ6; -.
DR ProteomicsDB; 62972; -.
DR ProteomicsDB; 73941; -. [Q8TAZ6-1]
DR Antibodypedia; 3086; 160 antibodies from 26 providers.
DR DNASU; 146225; -.
DR Ensembl; ENST00000268595.3; ENSP00000268595.2; ENSG00000140932.10. [Q8TAZ6-1]
DR Ensembl; ENST00000379486.6; ENSP00000368800.2; ENSG00000140932.10. [Q8TAZ6-2]
DR GeneID; 146225; -.
DR KEGG; hsa:146225; -.
DR MANE-Select; ENST00000268595.3; ENSP00000268595.2; NM_144673.3; NP_653274.1.
DR UCSC; uc002ept.4; human. [Q8TAZ6-1]
DR CTD; 146225; -.
DR DisGeNET; 146225; -.
DR GeneCards; CMTM2; -.
DR HGNC; HGNC:19173; CMTM2.
DR HPA; ENSG00000140932; Tissue enriched (testis).
DR MIM; 607885; gene.
DR neXtProt; NX_Q8TAZ6; -.
DR OpenTargets; ENSG00000140932; -.
DR PharmGKB; PA38812; -.
DR VEuPathDB; HostDB:ENSG00000140932; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00390000005715; -.
DR HOGENOM; CLU_106771_0_0_1; -.
DR InParanoid; Q8TAZ6; -.
DR OMA; FFIIIYT; -.
DR OrthoDB; 1328400at2759; -.
DR PhylomeDB; Q8TAZ6; -.
DR TreeFam; TF338711; -.
DR PathwayCommons; Q8TAZ6; -.
DR SignaLink; Q8TAZ6; -.
DR BioGRID-ORCS; 146225; 8 hits in 1067 CRISPR screens.
DR GeneWiki; CMTM2; -.
DR GenomeRNAi; 146225; -.
DR Pharos; Q8TAZ6; Tbio.
DR PRO; PR:Q8TAZ6; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8TAZ6; protein.
DR Bgee; ENSG00000140932; Expressed in sperm and 102 other tissues.
DR ExpressionAtlas; Q8TAZ6; baseline and differential.
DR Genevisible; Q8TAZ6; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..248
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 2"
FT /id="PRO_0000186098"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 82..204
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 96..148
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15896670"
FT /id="VSP_047061"
FT VARIANT 122
FT /note="I -> T (in dbSNP:rs2290182)"
FT /id="VAR_022154"
FT CONFLICT 172
FT /note="R -> Q (in Ref. 2; BAC05345)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 248 AA; 27496 MW; 9E2E8FEB4554D84F CRC64;
MAPKAAKGAK PEPAPAPPPP GAKPEEDKKD GKEPSDKPQK AVQDHKEPSD KPQKAVQPKH
EVGTRRGCRR YRWELKDSNK EFWLLGHAEI KIRSLGCLIA AMILLSSLTV HPILRLIITM
EISFFSFFIL LYSFAIHRYI PFILWPISDL FNDLIACAFL VGAVVFAVRS RRSMNLHYLL
AVILIGAAGV FAFIDVCLQR NHFRGKKAKK HMLVPPPGKE KGPQQGKGPE PAKPPEPGKP
PGPAKGKK
