CKLF3_HUMAN
ID CKLF3_HUMAN Reviewed; 182 AA.
AC Q96MX0; A6NCL9; Q8IUU8; Q8IWQ6; Q8IYE2; Q8IZ39; Q8IZ59;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 3;
DE AltName: Full=Chemokine-like factor superfamily member 3;
GN Name=CMTM3; Synonyms=CKLFSF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Liu Y., Han W., Shi S., Xia D., Song Q., Zhang Y., Ma D.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96MX0; Q6Q788: APOA5; NbExp=3; IntAct=EBI-7247651, EBI-3936819;
CC Q96MX0; Q13520: AQP6; NbExp=3; IntAct=EBI-7247651, EBI-13059134;
CC Q96MX0; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-7247651, EBI-11343438;
CC Q96MX0; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-7247651, EBI-6942903;
CC Q96MX0; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-7247651, EBI-18535450;
CC Q96MX0; P00488: F13A1; NbExp=3; IntAct=EBI-7247651, EBI-2565863;
CC Q96MX0; P08034: GJB1; NbExp=3; IntAct=EBI-7247651, EBI-17565645;
CC Q96MX0; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-7247651, EBI-1052304;
CC Q96MX0; Q70UQ0-4: IKBIP; NbExp=3; IntAct=EBI-7247651, EBI-12190633;
CC Q96MX0; Q13651: IL10RA; NbExp=3; IntAct=EBI-7247651, EBI-1031656;
CC Q96MX0; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-7247651, EBI-17490413;
CC Q96MX0; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-7247651, EBI-358888;
CC Q96MX0; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-7247651, EBI-373355;
CC Q96MX0; Q9H8S9: MOB1A; NbExp=3; IntAct=EBI-7247651, EBI-748229;
CC Q96MX0; Q70IA8: MOB3C; NbExp=3; IntAct=EBI-7247651, EBI-9679267;
CC Q96MX0; Q6IN84: MRM1; NbExp=3; IntAct=EBI-7247651, EBI-5454865;
CC Q96MX0; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-7247651, EBI-7545592;
CC Q96MX0; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-7247651, EBI-10192441;
CC Q96MX0; Q14973: SLC10A1; NbExp=3; IntAct=EBI-7247651, EBI-3923031;
CC Q96MX0; Q9H169-2: STMN4; NbExp=3; IntAct=EBI-7247651, EBI-20117546;
CC Q96MX0; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-7247651, EBI-8032987;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96MX0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MX0-2; Sequence=VSP_008256, VSP_008257;
CC -!- TISSUE SPECIFICITY: Expressed in the leukocytes, placenta and testis.
CC {ECO:0000269|PubMed:12782130}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF479813; AAN73435.1; -; mRNA.
DR EMBL; AY166714; AAN75573.1; -; mRNA.
DR EMBL; AK056324; BAB71150.1; -; mRNA.
DR EMBL; AC018557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471092; EAW83031.1; -; Genomic_DNA.
DR EMBL; BC023509; AAH23509.2; -; mRNA.
DR EMBL; BC023591; AAH23591.2; -; mRNA.
DR EMBL; BC036042; AAH36042.2; -; mRNA.
DR EMBL; BC040227; AAH40227.2; -; mRNA.
DR EMBL; BC047701; AAH47701.1; -; mRNA.
DR CCDS; CCDS10815.1; -. [Q96MX0-1]
DR RefSeq; NP_653202.1; NM_144601.3. [Q96MX0-1]
DR RefSeq; NP_853531.1; NM_181553.2. [Q96MX0-1]
DR RefSeq; XP_006721194.1; XM_006721131.1.
DR AlphaFoldDB; Q96MX0; -.
DR BioGRID; 125844; 31.
DR IntAct; Q96MX0; 25.
DR MINT; Q96MX0; -.
DR STRING; 9606.ENSP00000400482; -.
DR iPTMnet; Q96MX0; -.
DR PhosphoSitePlus; Q96MX0; -.
DR SwissPalm; Q96MX0; -.
DR BioMuta; CMTM3; -.
DR DMDM; 34922036; -.
DR EPD; Q96MX0; -.
DR MassIVE; Q96MX0; -.
DR MaxQB; Q96MX0; -.
DR PaxDb; Q96MX0; -.
DR PeptideAtlas; Q96MX0; -.
DR PRIDE; Q96MX0; -.
DR ProteomicsDB; 77426; -. [Q96MX0-1]
DR ProteomicsDB; 77427; -. [Q96MX0-2]
DR Antibodypedia; 2892; 141 antibodies from 22 providers.
DR DNASU; 123920; -.
DR Ensembl; ENST00000361909.8; ENSP00000354579.4; ENSG00000140931.20. [Q96MX0-1]
DR Ensembl; ENST00000424011.6; ENSP00000400482.2; ENSG00000140931.20. [Q96MX0-1]
DR Ensembl; ENST00000562707.5; ENSP00000455758.1; ENSG00000140931.20. [Q96MX0-1]
DR Ensembl; ENST00000565922.1; ENSP00000456426.1; ENSG00000140931.20. [Q96MX0-2]
DR Ensembl; ENST00000567572.6; ENSP00000455851.1; ENSG00000140931.20. [Q96MX0-1]
DR GeneID; 123920; -.
DR KEGG; hsa:123920; -.
DR MANE-Select; ENST00000567572.6; ENSP00000455851.1; NM_181553.4; NP_853531.1.
DR UCSC; uc002epu.5; human. [Q96MX0-1]
DR CTD; 123920; -.
DR DisGeNET; 123920; -.
DR GeneCards; CMTM3; -.
DR HGNC; HGNC:19174; CMTM3.
DR HPA; ENSG00000140931; Low tissue specificity.
DR MIM; 607886; gene.
DR neXtProt; NX_Q96MX0; -.
DR OpenTargets; ENSG00000140931; -.
DR PharmGKB; PA38813; -.
DR VEuPathDB; HostDB:ENSG00000140931; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000160432; -.
DR HOGENOM; CLU_108546_1_0_1; -.
DR InParanoid; Q96MX0; -.
DR OMA; WPLMDFV; -.
DR PhylomeDB; Q96MX0; -.
DR TreeFam; TF317387; -.
DR PathwayCommons; Q96MX0; -.
DR SignaLink; Q96MX0; -.
DR BioGRID-ORCS; 123920; 12 hits in 1072 CRISPR screens.
DR ChiTaRS; CMTM3; human.
DR GenomeRNAi; 123920; -.
DR Pharos; Q96MX0; Tbio.
DR PRO; PR:Q96MX0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96MX0; protein.
DR Bgee; ENSG00000140931; Expressed in granulocyte and 171 other tissues.
DR ExpressionAtlas; Q96MX0; baseline and differential.
DR Genevisible; Q96MX0; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:CACAO.
DR GO; GO:0005829; C:cytosol; IDA:CACAO.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..182
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 3"
FT /id="PRO_0000186101"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 36..155
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 43..59
FT /note="RLLLAESGLSFITFICY -> PGGFVCTWCSCPHQPLW (in isoform
FT 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008256"
FT VAR_SEQ 60..182
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008257"
SQ SEQUENCE 182 AA; 19714 MW; C56C7B93E7E638E1 CRC64;
MWPPDPDPDP DPEPAGGSRP GPAVPGLRAL LPARAFLCSL KGRLLLAESG LSFITFICYV
ASSASAFLTA PLLEFLLALY FLFADAMQLN DKWQGLCWPM MDFLRCVTAA LIYFAISITA
IAKYSDGASK AAGVFGFFAT IVFATDFYLI FNDVAKFLKQ GDSADETTAH KTEEENSDSD
SD
