CKLF3_MOUSE
ID CKLF3_MOUSE Reviewed; 184 AA.
AC Q99LJ5; A6H6B5; Q8BJU1; Q9D165;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 3;
DE AltName: Full=Chemokine-like factor superfamily member 3;
GN Name=Cmtm3; Synonyms=Cklfsf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RA Han W., Li T., Tan Y., Shi S., Ding P., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB23056.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY241870; AAP33492.1; -; mRNA.
DR EMBL; AK003882; BAB23056.1; ALT_FRAME; mRNA.
DR EMBL; AK079165; BAC37565.1; -; mRNA.
DR EMBL; BC003230; AAH03230.1; -; mRNA.
DR EMBL; BC145817; AAI45818.1; -; mRNA.
DR EMBL; BC145819; AAI45820.1; -; mRNA.
DR CCDS; CCDS22577.1; -.
DR RefSeq; NP_077179.1; NM_024217.3.
DR RefSeq; XP_006531389.1; XM_006531326.1.
DR RefSeq; XP_006531390.1; XM_006531327.2.
DR RefSeq; XP_006531391.1; XM_006531328.1.
DR RefSeq; XP_006531392.1; XM_006531329.2.
DR AlphaFoldDB; Q99LJ5; -.
DR BioGRID; 212666; 2.
DR CORUM; Q99LJ5; -.
DR STRING; 10090.ENSMUSP00000034343; -.
DR iPTMnet; Q99LJ5; -.
DR PhosphoSitePlus; Q99LJ5; -.
DR SwissPalm; Q99LJ5; -.
DR MaxQB; Q99LJ5; -.
DR PaxDb; Q99LJ5; -.
DR PRIDE; Q99LJ5; -.
DR ProteomicsDB; 281631; -.
DR Antibodypedia; 2892; 141 antibodies from 22 providers.
DR DNASU; 68119; -.
DR Ensembl; ENSMUST00000034343; ENSMUSP00000034343; ENSMUSG00000031875.
DR Ensembl; ENSMUST00000212081; ENSMUSP00000148682; ENSMUSG00000031875.
DR GeneID; 68119; -.
DR KEGG; mmu:68119; -.
DR UCSC; uc009nam.1; mouse.
DR CTD; 123920; -.
DR MGI; MGI:2447162; Cmtm3.
DR VEuPathDB; HostDB:ENSMUSG00000031875; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000160432; -.
DR HOGENOM; CLU_108546_1_0_1; -.
DR InParanoid; Q99LJ5; -.
DR OMA; WPLMDFV; -.
DR OrthoDB; 1578763at2759; -.
DR PhylomeDB; Q99LJ5; -.
DR TreeFam; TF317387; -.
DR BioGRID-ORCS; 68119; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q99LJ5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q99LJ5; protein.
DR Bgee; ENSMUSG00000031875; Expressed in decidua and 243 other tissues.
DR ExpressionAtlas; Q99LJ5; baseline and differential.
DR Genevisible; Q99LJ5; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IDA:MGI.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..184
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 3"
FT /id="PRO_0000186102"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 36..155
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 146
FT /note="D -> G (in Ref. 2; BAC37565)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20247 MW; 6FBB899137D51EB3 CRC64;
MWPPDAEPEP DPESAHGPRS GRTVPGLRAL LPARAFLCSL KGRLLLAESG LSFITFICYV
VSSASAFLTV PLLEFLLAVY FLFADAMQLN DKWQGLCWPM MDFLRCVTAA LIYFVISITA
VAKYSDGAYK AAGVFGFFAT IVFAIDFYLI FNEVAKFLKQ GDSGNETTAH RTEEENSNSD
SDSD
