CKLF4_MOUSE
ID CKLF4_MOUSE Reviewed; 208 AA.
AC Q8CJ61; Q8K143;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 4;
DE AltName: Full=Chemokine-like factor superfamily member 4;
GN Name=Cmtm4 {ECO:0000312|MGI:MGI:2142888}; Synonyms=Cklfsf4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RA Han W., Ding P., Wang L., Wang Y., Qiu X., Chen Y., Tan Y., Song Q.,
RA Zhang Y., Ma D.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a backup for CMTM6 to regulate plasma membrane
CC expression of PD-L1/CD274, an immune inhibitory ligand critical for
CC immune tolerance to self and antitumor immunity. May protect PD-
CC L1/CD274 from being polyubiquitinated and targeted for degradation.
CC {ECO:0000250|UniProtKB:Q8IZR5}.
CC -!- SUBUNIT: Interacts with PD1L1 and CMTM6.
CC {ECO:0000250|UniProtKB:Q8IZR5}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF479815; AAN73437.1; -; mRNA.
DR EMBL; BC028852; AAH28852.2; -; mRNA.
DR CCDS; CCDS22578.1; -.
DR RefSeq; NP_705810.2; NM_153582.5.
DR AlphaFoldDB; Q8CJ61; -.
DR STRING; 10090.ENSMUSP00000137332; -.
DR iPTMnet; Q8CJ61; -.
DR PhosphoSitePlus; Q8CJ61; -.
DR MaxQB; Q8CJ61; -.
DR PaxDb; Q8CJ61; -.
DR PeptideAtlas; Q8CJ61; -.
DR PRIDE; Q8CJ61; -.
DR ProteomicsDB; 283929; -.
DR Antibodypedia; 15544; 145 antibodies from 26 providers.
DR DNASU; 97487; -.
DR Ensembl; ENSMUST00000179802; ENSMUSP00000137332; ENSMUSG00000096188.
DR GeneID; 97487; -.
DR KEGG; mmu:97487; -.
DR UCSC; uc009nan.2; mouse.
DR CTD; 146223; -.
DR MGI; MGI:2142888; Cmtm4.
DR VEuPathDB; HostDB:ENSMUSG00000096188; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000159573; -.
DR HOGENOM; CLU_104458_0_0_1; -.
DR InParanoid; Q8CJ61; -.
DR OMA; SFICIET; -.
DR OrthoDB; 1400503at2759; -.
DR PhylomeDB; Q8CJ61; -.
DR TreeFam; TF317387; -.
DR BioGRID-ORCS; 97487; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cmtm4; mouse.
DR PRO; PR:Q8CJ61; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8CJ61; protein.
DR Bgee; ENSMUSG00000096188; Expressed in dorsal pancreas and 214 other tissues.
DR Genevisible; Q8CJ61; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..208
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 4"
FT /id="PRO_0000186104"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..176
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZR5"
SQ SEQUENCE 208 AA; 22921 MW; CDC27CDE02EDA06E CRC64;
MRGGEELDGF EGEASSTSMI SGASSPYQPT TEPVSQRRGL AGLRCDPDYL RGALGRLKVA
QVILALIAFI CIETIMECSP CEGLYFFEFV SCSAFVVTGV LLILFSLNLH MRIPQINWNL
TDLVNTGLST FFFFIASIVL AALNHKTGAE IAAVIFGFLA TAAYAVSTFL AMQKWRVSVR
QQSTNDYIRA RTESRDVDSR PEIQRLDT
