CKLF5_HUMAN
ID CKLF5_HUMAN Reviewed; 223 AA.
AC Q96DZ9; E9PH91; Q5PY48;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2003, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 5;
DE AltName: Full=Chemokine-like factor superfamily member 5;
GN Name=CMTM5; Synonyms=CKLFSF5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 6), AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
RC TISSUE=Brain, Pancreas, and Prostatic carcinoma;
RA Shi S., Han W., Ding P., Yang T., Song Q., Zhang Y., Ma D.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96DZ9; Q86V21: AACS; NbExp=3; IntAct=EBI-2548702, EBI-10259474;
CC Q96DZ9; Q96CM8: ACSF2; NbExp=5; IntAct=EBI-2548702, EBI-2876502;
CC Q96DZ9; P54886: ALDH18A1; NbExp=3; IntAct=EBI-2548702, EBI-1210304;
CC Q96DZ9; P02647: APOA1; NbExp=3; IntAct=EBI-2548702, EBI-701692;
CC Q96DZ9; Q7Z3E5-2: ARMC9; NbExp=3; IntAct=EBI-2548702, EBI-10256990;
CC Q96DZ9; P04798: CYP1A1; NbExp=3; IntAct=EBI-2548702, EBI-10194262;
CC Q96DZ9; Q9BW61: DDA1; NbExp=3; IntAct=EBI-2548702, EBI-2510241;
CC Q96DZ9; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-2548702, EBI-521451;
CC Q96DZ9; P54852: EMP3; NbExp=3; IntAct=EBI-2548702, EBI-3907816;
CC Q96DZ9; Q8IWE2: FAM114A1; NbExp=3; IntAct=EBI-2548702, EBI-2686288;
CC Q96DZ9; O95363: FARS2; NbExp=3; IntAct=EBI-2548702, EBI-2513774;
CC Q96DZ9; Q8IVA8: GAD1; NbExp=3; IntAct=EBI-2548702, EBI-10209663;
CC Q96DZ9; Q99259: GAD1; NbExp=4; IntAct=EBI-2548702, EBI-743184;
CC Q96DZ9; Q05329: GAD2; NbExp=3; IntAct=EBI-2548702, EBI-9304251;
CC Q96DZ9; Q9NZD2: GLTP; NbExp=4; IntAct=EBI-2548702, EBI-2859814;
CC Q96DZ9; Q12789: GTF3C1; NbExp=3; IntAct=EBI-2548702, EBI-357956;
CC Q96DZ9; P25791: LMO2; NbExp=3; IntAct=EBI-2548702, EBI-739696;
CC Q96DZ9; Q96PE7: MCEE; NbExp=4; IntAct=EBI-2548702, EBI-10292326;
CC Q96DZ9; Q96E29: MTERF3; NbExp=3; IntAct=EBI-2548702, EBI-7825321;
CC Q96DZ9; Q9HB07: MYG1; NbExp=4; IntAct=EBI-2548702, EBI-709754;
CC Q96DZ9; Q9ULP0: NDRG4; NbExp=3; IntAct=EBI-2548702, EBI-10323810;
CC Q96DZ9; Q9UKF7: PITPNC1; NbExp=3; IntAct=EBI-2548702, EBI-749241;
CC Q96DZ9; O60664: PLIN3; NbExp=3; IntAct=EBI-2548702, EBI-725795;
CC Q96DZ9; P30405: PPIF; NbExp=3; IntAct=EBI-2548702, EBI-5544229;
CC Q96DZ9; Q969Q6: PPP2R3C; NbExp=3; IntAct=EBI-2548702, EBI-2561661;
CC Q96DZ9; P43378: PTPN9; NbExp=4; IntAct=EBI-2548702, EBI-742898;
CC Q96DZ9; Q6IQ43: PTPN9; NbExp=3; IntAct=EBI-2548702, EBI-10250413;
CC Q96DZ9; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-2548702, EBI-3232108;
CC Q96DZ9; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-2548702, EBI-2806908;
CC Q96DZ9; Q96GF1: RNF185; NbExp=3; IntAct=EBI-2548702, EBI-2340249;
CC Q96DZ9; Q7L4I2-2: RSRC2; NbExp=3; IntAct=EBI-2548702, EBI-10256202;
CC Q96DZ9; O00560: SDCBP; NbExp=3; IntAct=EBI-2548702, EBI-727004;
CC Q96DZ9; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-2548702, EBI-2623095;
CC Q96DZ9; P34897: SHMT2; NbExp=4; IntAct=EBI-2548702, EBI-352908;
CC Q96DZ9; Q13596: SNX1; NbExp=3; IntAct=EBI-2548702, EBI-2822329;
CC Q96DZ9; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-2548702, EBI-8635958;
CC Q96DZ9; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-2548702, EBI-742688;
CC Q96DZ9; Q99909: SSX3; NbExp=3; IntAct=EBI-2548702, EBI-10295431;
CC Q96DZ9; E5KS60: SUCLA2; NbExp=3; IntAct=EBI-2548702, EBI-10176959;
CC Q96DZ9; Q8N205: SYNE4; NbExp=3; IntAct=EBI-2548702, EBI-7131783;
CC Q96DZ9; O43615: TIMM44; NbExp=3; IntAct=EBI-2548702, EBI-861737;
CC Q96DZ9; Q96J77: TPD52L3; NbExp=3; IntAct=EBI-2548702, EBI-932162;
CC Q96DZ9; P49638: TTPA; NbExp=3; IntAct=EBI-2548702, EBI-10210710;
CC Q96DZ9; Q5SU16: TUBB; NbExp=3; IntAct=EBI-2548702, EBI-10245038;
CC Q96DZ9; Q6P602: TUBB; NbExp=3; IntAct=EBI-2548702, EBI-10253109;
CC Q96DZ9; P49411: TUFM; NbExp=3; IntAct=EBI-2548702, EBI-359097;
CC Q96DZ9; Q5ST30-3: VARS2; NbExp=3; IntAct=EBI-2548702, EBI-10244969;
CC Q96DZ9-2; Q8TB40: ABHD4; NbExp=3; IntAct=EBI-11522780, EBI-7131019;
CC Q96DZ9-2; Q96CM8: ACSF2; NbExp=3; IntAct=EBI-11522780, EBI-2876502;
CC Q96DZ9-2; Q08AH1: ACSM1; NbExp=3; IntAct=EBI-11522780, EBI-2818055;
CC Q96DZ9-2; P02647: APOA1; NbExp=6; IntAct=EBI-11522780, EBI-701692;
CC Q96DZ9-2; P06727: APOA4; NbExp=3; IntAct=EBI-11522780, EBI-1222447;
CC Q96DZ9-2; Q6Q788: APOA5; NbExp=3; IntAct=EBI-11522780, EBI-3936819;
CC Q96DZ9-2; Q13520: AQP6; NbExp=3; IntAct=EBI-11522780, EBI-13059134;
CC Q96DZ9-2; P53367: ARFIP1; NbExp=3; IntAct=EBI-11522780, EBI-2808808;
CC Q96DZ9-2; P53365: ARFIP2; NbExp=3; IntAct=EBI-11522780, EBI-638194;
CC Q96DZ9-2; Q13323: BIK; NbExp=3; IntAct=EBI-11522780, EBI-700794;
CC Q96DZ9-2; Q12983: BNIP3; NbExp=3; IntAct=EBI-11522780, EBI-749464;
CC Q96DZ9-2; Q96L46: CAPNS2; NbExp=3; IntAct=EBI-11522780, EBI-12188723;
CC Q96DZ9-2; O95971: CD160; NbExp=3; IntAct=EBI-11522780, EBI-4314390;
CC Q96DZ9-2; P25942: CD40; NbExp=3; IntAct=EBI-11522780, EBI-525714;
CC Q96DZ9-2; P11912: CD79A; NbExp=3; IntAct=EBI-11522780, EBI-7797864;
CC Q96DZ9-2; O95471: CLDN7; NbExp=3; IntAct=EBI-11522780, EBI-740744;
CC Q96DZ9-2; Q8NI60: COQ8A; NbExp=6; IntAct=EBI-11522780, EBI-745535;
CC Q96DZ9-2; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-11522780, EBI-18013275;
CC Q96DZ9-2; P04798: CYP1A1; NbExp=3; IntAct=EBI-11522780, EBI-10194262;
CC Q96DZ9-2; Q9BW61: DDA1; NbExp=3; IntAct=EBI-11522780, EBI-2510241;
CC Q96DZ9-2; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-11522780, EBI-3923585;
CC Q96DZ9-2; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-11522780, EBI-521451;
CC Q96DZ9-2; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-11522780, EBI-18535450;
CC Q96DZ9-2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11522780, EBI-781551;
CC Q96DZ9-2; Q8IWE2: FAM114A1; NbExp=3; IntAct=EBI-11522780, EBI-2686288;
CC Q96DZ9-2; O95363: FARS2; NbExp=3; IntAct=EBI-11522780, EBI-2513774;
CC Q96DZ9-2; P12318-2: FCGR2A; NbExp=3; IntAct=EBI-11522780, EBI-17187481;
CC Q96DZ9-2; Q96P31-6: FCRL3; NbExp=3; IntAct=EBI-11522780, EBI-17443171;
CC Q96DZ9-2; O15552: FFAR2; NbExp=3; IntAct=EBI-11522780, EBI-2833872;
CC Q96DZ9-2; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-11522780, EBI-12142257;
CC Q96DZ9-2; A0A0S2Z4D9: GAD1; NbExp=4; IntAct=EBI-11522780, EBI-16430771;
CC Q96DZ9-2; Q99259: GAD1; NbExp=6; IntAct=EBI-11522780, EBI-743184;
CC Q96DZ9-2; Q05329: GAD2; NbExp=3; IntAct=EBI-11522780, EBI-9304251;
CC Q96DZ9-2; P08034: GJB1; NbExp=3; IntAct=EBI-11522780, EBI-17565645;
CC Q96DZ9-2; Q8TED1: GPX8; NbExp=3; IntAct=EBI-11522780, EBI-11721746;
CC Q96DZ9-2; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-11522780, EBI-18053395;
CC Q96DZ9-2; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-11522780, EBI-10266796;
CC Q96DZ9-2; Q8TAC2: JOSD2; NbExp=3; IntAct=EBI-11522780, EBI-12205593;
CC Q96DZ9-2; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-11522780, EBI-749265;
CC Q96DZ9-2; P48051: KCNJ6; NbExp=3; IntAct=EBI-11522780, EBI-12017638;
CC Q96DZ9-2; O95279: KCNK5; NbExp=3; IntAct=EBI-11522780, EBI-3934936;
CC Q96DZ9-2; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-11522780, EBI-17272405;
CC Q96DZ9-2; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-11522780, EBI-17490413;
CC Q96DZ9-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11522780, EBI-739832;
CC Q96DZ9-2; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-11522780, EBI-3925442;
CC Q96DZ9-2; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-11522780, EBI-358888;
CC Q96DZ9-2; Q96PE7: MCEE; NbExp=6; IntAct=EBI-11522780, EBI-10292326;
CC Q96DZ9-2; Q8IX19: MCEMP1; NbExp=3; IntAct=EBI-11522780, EBI-2816356;
CC Q96DZ9-2; Q8NI22: MCFD2; NbExp=3; IntAct=EBI-11522780, EBI-2689785;
CC Q96DZ9-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11522780, EBI-16439278;
CC Q96DZ9-2; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-11522780, EBI-11956541;
CC Q96DZ9-2; O14880: MGST3; NbExp=3; IntAct=EBI-11522780, EBI-724754;
CC Q96DZ9-2; Q9NQG6: MIEF1; NbExp=3; IntAct=EBI-11522780, EBI-740987;
CC Q96DZ9-2; Q6IN84: MRM1; NbExp=3; IntAct=EBI-11522780, EBI-5454865;
CC Q96DZ9-2; Q96E11: MRRF; NbExp=3; IntAct=EBI-11522780, EBI-2855755;
CC Q96DZ9-2; Q96E29: MTERF3; NbExp=3; IntAct=EBI-11522780, EBI-7825321;
CC Q96DZ9-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11522780, EBI-3923617;
CC Q96DZ9-2; Q9HB07: MYG1; NbExp=3; IntAct=EBI-11522780, EBI-709754;
CC Q96DZ9-2; Q9ULP0-2: NDRG4; NbExp=7; IntAct=EBI-11522780, EBI-11978907;
CC Q96DZ9-2; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-11522780, EBI-725252;
CC Q96DZ9-2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11522780, EBI-741158;
CC Q96DZ9-2; Q96AL5: PBX3; NbExp=3; IntAct=EBI-11522780, EBI-741171;
CC Q96DZ9-2; P12004: PCNA; NbExp=3; IntAct=EBI-11522780, EBI-358311;
CC Q96DZ9-2; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-11522780, EBI-2568609;
CC Q96DZ9-2; Q9UKF7-2: PITPNC1; NbExp=3; IntAct=EBI-11522780, EBI-14223623;
CC Q96DZ9-2; O60664: PLIN3; NbExp=3; IntAct=EBI-11522780, EBI-725795;
CC Q96DZ9-2; Q9NVS9: PNPO; NbExp=3; IntAct=EBI-11522780, EBI-11030787;
CC Q96DZ9-2; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-11522780, EBI-10320765;
CC Q96DZ9-2; P43378: PTPN9; NbExp=3; IntAct=EBI-11522780, EBI-742898;
CC Q96DZ9-2; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-11522780, EBI-3232108;
CC Q96DZ9-2; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-11522780, EBI-11337973;
CC Q96DZ9-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-11522780, EBI-10192441;
CC Q96DZ9-2; Q8TEB9: RHBDD1; NbExp=3; IntAct=EBI-11522780, EBI-9916444;
CC Q96DZ9-2; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-11522780, EBI-2806908;
CC Q96DZ9-2; Q7L4I2: RSRC2; NbExp=3; IntAct=EBI-11522780, EBI-953753;
CC Q96DZ9-2; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-11522780, EBI-8636004;
CC Q96DZ9-2; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-11522780, EBI-3920694;
CC Q96DZ9-2; Q6ZMJ2-2: SCARA5; NbExp=3; IntAct=EBI-11522780, EBI-12823227;
CC Q96DZ9-2; O00560: SDCBP; NbExp=3; IntAct=EBI-11522780, EBI-727004;
CC Q96DZ9-2; Q16585: SGCB; NbExp=3; IntAct=EBI-11522780, EBI-5663627;
CC Q96DZ9-2; Q99961: SH3GL1; NbExp=3; IntAct=EBI-11522780, EBI-697911;
CC Q96DZ9-2; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-11522780, EBI-2623095;
CC Q96DZ9-2; P34897: SHMT2; NbExp=3; IntAct=EBI-11522780, EBI-352908;
CC Q96DZ9-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-11522780, EBI-18159983;
CC Q96DZ9-2; Q05940: SLC18A2; NbExp=3; IntAct=EBI-11522780, EBI-18036244;
CC Q96DZ9-2; O14863: SLC30A4; NbExp=3; IntAct=EBI-11522780, EBI-13918058;
CC Q96DZ9-2; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-11522780, EBI-17295964;
CC Q96DZ9-2; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-11522780, EBI-5235586;
CC Q96DZ9-2; Q13596: SNX1; NbExp=3; IntAct=EBI-11522780, EBI-2822329;
CC Q96DZ9-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11522780, EBI-742688;
CC Q96DZ9-2; Q99909: SSX3; NbExp=3; IntAct=EBI-11522780, EBI-10295431;
CC Q96DZ9-2; O60225-2: SSX5; NbExp=3; IntAct=EBI-11522780, EBI-12033476;
CC Q96DZ9-2; Q86WV6: STING1; NbExp=3; IntAct=EBI-11522780, EBI-2800345;
CC Q96DZ9-2; P27105: STOM; NbExp=3; IntAct=EBI-11522780, EBI-1211440;
CC Q96DZ9-2; Q9P2R7: SUCLA2; NbExp=6; IntAct=EBI-11522780, EBI-2269898;
CC Q96DZ9-2; Q17RD7: SYT16; NbExp=3; IntAct=EBI-11522780, EBI-10238936;
CC Q96DZ9-2; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-11522780, EBI-702328;
CC Q96DZ9-2; Q8WY91: THAP4; NbExp=3; IntAct=EBI-11522780, EBI-726691;
CC Q96DZ9-2; O43615: TIMM44; NbExp=3; IntAct=EBI-11522780, EBI-861737;
CC Q96DZ9-2; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-11522780, EBI-12947623;
CC Q96DZ9-2; Q6PL24: TMED8; NbExp=3; IntAct=EBI-11522780, EBI-11603430;
CC Q96DZ9-2; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-11522780, EBI-7238458;
CC Q96DZ9-2; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-11522780, EBI-8638294;
CC Q96DZ9-2; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-11522780, EBI-11722971;
CC Q96DZ9-2; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-11522780, EBI-11742770;
CC Q96DZ9-2; P82094: TMF1; NbExp=3; IntAct=EBI-11522780, EBI-949763;
CC Q96DZ9-2; Q12999: TSPAN31; NbExp=3; IntAct=EBI-11522780, EBI-17678331;
CC Q96DZ9-2; P49638: TTPA; NbExp=3; IntAct=EBI-11522780, EBI-10210710;
CC Q96DZ9-2; A0A384ME17: TUFM; NbExp=6; IntAct=EBI-11522780, EBI-12261790;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q96DZ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DZ9-2; Sequence=VSP_008265;
CC Name=3;
CC IsoId=Q96DZ9-3; Sequence=VSP_008262, VSP_008265;
CC Name=4;
CC IsoId=Q96DZ9-4; Sequence=VSP_008264;
CC Name=5;
CC IsoId=Q96DZ9-5; Sequence=VSP_008263;
CC Name=6;
CC IsoId=Q96DZ9-6; Sequence=VSP_047120;
CC -!- TISSUE SPECIFICITY: Highly expressed in the brain.
CC {ECO:0000269|PubMed:12782130}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF479262; AAN73040.1; -; mRNA.
DR EMBL; AY820135; AAV69870.1; -; mRNA.
DR EMBL; AF527413; AAQ08985.1; -; mRNA.
DR EMBL; AF527414; AAQ08986.1; -; mRNA.
DR EMBL; AF527948; AAQ09008.2; -; mRNA.
DR EMBL; AF527949; AAQ09009.1; -; mRNA.
DR EMBL; AL049829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013109; AAH13109.1; -; mRNA.
DR CCDS; CCDS32050.1; -. [Q96DZ9-6]
DR CCDS; CCDS73617.1; -. [Q96DZ9-1]
DR CCDS; CCDS73618.1; -. [Q96DZ9-5]
DR CCDS; CCDS73619.1; -. [Q96DZ9-4]
DR CCDS; CCDS9598.1; -. [Q96DZ9-2]
DR RefSeq; NP_001032365.1; NM_001037288.1. [Q96DZ9-6]
DR RefSeq; NP_001275673.1; NM_001288744.1. [Q96DZ9-5]
DR RefSeq; NP_001275674.1; NM_001288745.1. [Q96DZ9-4]
DR RefSeq; NP_001275675.1; NM_001288746.1. [Q96DZ9-1]
DR RefSeq; NP_612469.1; NM_138460.2. [Q96DZ9-2]
DR RefSeq; XP_016876442.1; XM_017020953.1.
DR RefSeq; XP_016876443.1; XM_017020954.1.
DR AlphaFoldDB; Q96DZ9; -.
DR BioGRID; 125486; 331.
DR IntAct; Q96DZ9; 135.
DR MINT; Q96DZ9; -.
DR STRING; 9606.ENSP00000344819; -.
DR TCDB; 1.A.64.5.8; the plasmolipin (plasmolipin) family.
DR PhosphoSitePlus; Q96DZ9; -.
DR SwissPalm; Q96DZ9; -.
DR BioMuta; CMTM5; -.
DR DMDM; 34922025; -.
DR jPOST; Q96DZ9; -.
DR MassIVE; Q96DZ9; -.
DR PaxDb; Q96DZ9; -.
DR PeptideAtlas; Q96DZ9; -.
DR PRIDE; Q96DZ9; -.
DR ProteomicsDB; 20482; -.
DR ProteomicsDB; 76348; -. [Q96DZ9-1]
DR ProteomicsDB; 76349; -. [Q96DZ9-2]
DR ProteomicsDB; 76350; -. [Q96DZ9-3]
DR ProteomicsDB; 76351; -. [Q96DZ9-4]
DR ProteomicsDB; 76352; -. [Q96DZ9-5]
DR Antibodypedia; 22460; 236 antibodies from 26 providers.
DR DNASU; 116173; -.
DR Ensembl; ENST00000339180.9; ENSP00000344819.4; ENSG00000166091.21. [Q96DZ9-1]
DR Ensembl; ENST00000342473.8; ENSP00000344160.4; ENSG00000166091.21. [Q96DZ9-4]
DR Ensembl; ENST00000359320.7; ENSP00000352270.3; ENSG00000166091.21. [Q96DZ9-2]
DR Ensembl; ENST00000382809.2; ENSP00000372259.2; ENSG00000166091.21. [Q96DZ9-6]
DR Ensembl; ENST00000397227.7; ENSP00000380404.3; ENSG00000166091.21. [Q96DZ9-5]
DR Ensembl; ENST00000649278.1; ENSP00000497215.1; ENSG00000166091.21. [Q96DZ9-2]
DR GeneID; 116173; -.
DR KEGG; hsa:116173; -.
DR MANE-Select; ENST00000339180.9; ENSP00000344819.4; NM_001288746.2; NP_001275675.1.
DR UCSC; uc001wjs.3; human. [Q96DZ9-1]
DR CTD; 116173; -.
DR DisGeNET; 116173; -.
DR GeneCards; CMTM5; -.
DR HGNC; HGNC:19176; CMTM5.
DR HPA; ENSG00000166091; Group enriched (brain, choroid plexus).
DR MIM; 607888; gene.
DR neXtProt; NX_Q96DZ9; -.
DR OpenTargets; ENSG00000166091; -.
DR PharmGKB; PA38815; -.
DR VEuPathDB; HostDB:ENSG00000166091; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000161867; -.
DR HOGENOM; CLU_108546_0_0_1; -.
DR InParanoid; Q96DZ9; -.
DR OMA; YATQYHQ; -.
DR OrthoDB; 1575715at2759; -.
DR PhylomeDB; Q96DZ9; -.
DR TreeFam; TF317387; -.
DR PathwayCommons; Q96DZ9; -.
DR SignaLink; Q96DZ9; -.
DR BioGRID-ORCS; 116173; 6 hits in 1060 CRISPR screens.
DR GenomeRNAi; 116173; -.
DR Pharos; Q96DZ9; Tbio.
DR PRO; PR:Q96DZ9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q96DZ9; protein.
DR Bgee; ENSG00000166091; Expressed in C1 segment of cervical spinal cord and 128 other tissues.
DR ExpressionAtlas; Q96DZ9; baseline and differential.
DR Genevisible; Q96DZ9; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..223
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 5"
FT /id="PRO_0000186105"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 29..213
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 43..191
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008264"
FT VAR_SEQ 43..160
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008263"
FT VAR_SEQ 43..81
FT /note="ALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQY -> D (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008262"
FT VAR_SEQ 94..191
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:12782130"
FT /id="VSP_047120"
FT VAR_SEQ 94..160
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:12782130,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_008265"
FT CONFLICT 192
FT /note="V -> D (in Ref. 1; AAV69870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 223 AA; 24653 MW; 26AC880FFC8E1F50 CRC64;
MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI CFTASISAYM
AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS GGPHPLDLLS HSAKVQPQPW
PGLTPPGWHT PAAVPWVPAP APGFWSWLLW FICFHSLGSS DFLRCVSAII IFLVVSFAAV
TSRDGAAIAA FVFGIILVSI FAYDAFKIYR TEMAPGASQG DQQ
