CKLF5_MOUSE
ID CKLF5_MOUSE Reviewed; 156 AA.
AC Q9D6G9; Q9DB66;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 5;
DE AltName: Full=Chemokine-like factor superfamily member 5;
GN Name=Cmtm5; Synonyms=Cklfsf5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Han W., Li T., Tan Y., Shi S., Ding P., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 9-27 AND 144-156, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D6G9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D6G9-2; Sequence=VSP_008266;
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AY241867; AAP33489.1; -; mRNA.
DR EMBL; AK005168; BAB23858.1; -; mRNA.
DR EMBL; AK013666; BAB28947.1; -; mRNA.
DR EMBL; BC049665; AAH49665.1; -; mRNA.
DR CCDS; CCDS27105.1; -. [Q9D6G9-1]
DR RefSeq; NP_080342.1; NM_026066.2. [Q9D6G9-1]
DR RefSeq; XP_017171651.1; XM_017316162.1. [Q9D6G9-1]
DR AlphaFoldDB; Q9D6G9; -.
DR BioGRID; 212063; 1.
DR IntAct; Q9D6G9; 2.
DR MINT; Q9D6G9; -.
DR STRING; 10090.ENSMUSP00000036138; -.
DR iPTMnet; Q9D6G9; -.
DR PhosphoSitePlus; Q9D6G9; -.
DR SwissPalm; Q9D6G9; -.
DR PaxDb; Q9D6G9; -.
DR PRIDE; Q9D6G9; -.
DR ProteomicsDB; 281632; -. [Q9D6G9-1]
DR ProteomicsDB; 281633; -. [Q9D6G9-2]
DR Antibodypedia; 22460; 236 antibodies from 26 providers.
DR DNASU; 67272; -.
DR Ensembl; ENSMUST00000037814; ENSMUSP00000036138; ENSMUSG00000040759. [Q9D6G9-1]
DR GeneID; 67272; -.
DR KEGG; mmu:67272; -.
DR UCSC; uc007txo.1; mouse. [Q9D6G9-1]
DR CTD; 116173; -.
DR MGI; MGI:2447164; Cmtm5.
DR VEuPathDB; HostDB:ENSMUSG00000040759; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000161867; -.
DR HOGENOM; CLU_108546_0_0_1; -.
DR InParanoid; Q9D6G9; -.
DR OMA; YATQYHQ; -.
DR OrthoDB; 1575715at2759; -.
DR PhylomeDB; Q9D6G9; -.
DR TreeFam; TF317387; -.
DR BioGRID-ORCS; 67272; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Cmtm5; mouse.
DR PRO; PR:Q9D6G9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9D6G9; protein.
DR Bgee; ENSMUSG00000040759; Expressed in cerebellar nuclear complex and 149 other tissues.
DR ExpressionAtlas; Q9D6G9; baseline and differential.
DR Genevisible; Q9D6G9; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Direct protein sequencing;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..156
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 5"
FT /id="PRO_0000186106"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 29..146
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 44..93
FT /note="LTFIIFICFTASISAYMAAALLEFLITLAFLFLCATQYYQRFDRLNWPCL
FT -> PQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008266"
SQ SEQUENCE 156 AA; 17389 MW; 450F36EA49D737BE CRC64;
MFSAWDRRER PPEEGAAAGL QGFGVDKTFL SSLKGILLET ELALTFIIFI CFTASISAYM
AAALLEFLIT LAFLFLCATQ YYQRFDRLNW PCLDFLRCLS AIVIFLVVSF AAVTSREGAA
IAAFVFGIIL VSVFAYDAFK IYRTELMPST TEGDQQ
