CKLF7_HUMAN
ID CKLF7_HUMAN Reviewed; 175 AA.
AC Q96FZ5; Q5VLK1;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 7;
DE AltName: Full=Chemokine-like factor superfamily member 7;
GN Name=CMTM7; Synonyms=CKLFSF7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Sawada T., Kanai T., Watanabe M.;
RT "An alternatively spliced form of KSS, KSS b.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96FZ5; Q96IZ2: ADTRP; NbExp=3; IntAct=EBI-2807956, EBI-3921528;
CC Q96FZ5; Q15109: AGER; NbExp=3; IntAct=EBI-2807956, EBI-1646426;
CC Q96FZ5; Q13520: AQP6; NbExp=3; IntAct=EBI-2807956, EBI-13059134;
CC Q96FZ5; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-2807956, EBI-11343438;
CC Q96FZ5; Q9P2W7: B3GAT1; NbExp=3; IntAct=EBI-2807956, EBI-3918235;
CC Q96FZ5; Q13323: BIK; NbExp=3; IntAct=EBI-2807956, EBI-700794;
CC Q96FZ5; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-2807956, EBI-11532900;
CC Q96FZ5; P04233-2: CD74; NbExp=3; IntAct=EBI-2807956, EBI-12222807;
CC Q96FZ5; P11912: CD79A; NbExp=3; IntAct=EBI-2807956, EBI-7797864;
CC Q96FZ5; Q9BQT9: CLSTN3; NbExp=3; IntAct=EBI-2807956, EBI-11291074;
CC Q96FZ5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-2807956, EBI-6942903;
CC Q96FZ5; Q9Y4D2: DAGLA; NbExp=3; IntAct=EBI-2807956, EBI-12808806;
CC Q96FZ5; Q96KC8: DNAJC1; NbExp=3; IntAct=EBI-2807956, EBI-296550;
CC Q96FZ5; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-2807956, EBI-18535450;
CC Q96FZ5; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-2807956, EBI-18636064;
CC Q96FZ5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2807956, EBI-18304435;
CC Q96FZ5; O15552: FFAR2; NbExp=3; IntAct=EBI-2807956, EBI-2833872;
CC Q96FZ5; A2A2Y4: FRMD3; NbExp=3; IntAct=EBI-2807956, EBI-6911547;
CC Q96FZ5; Q9UJ14: GGT7; NbExp=3; IntAct=EBI-2807956, EBI-1058791;
CC Q96FZ5; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-2807956, EBI-3917143;
CC Q96FZ5; O00219-2: HAS3; NbExp=3; IntAct=EBI-2807956, EBI-17186025;
CC Q96FZ5; P31937: HIBADH; NbExp=3; IntAct=EBI-2807956, EBI-11427100;
CC Q96FZ5; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2807956, EBI-18053395;
CC Q96FZ5; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-2807956, EBI-10173166;
CC Q96FZ5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-2807956, EBI-2820517;
CC Q96FZ5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-2807956, EBI-12820341;
CC Q96FZ5; P15941-11: MUC1; NbExp=3; IntAct=EBI-2807956, EBI-17263240;
CC Q96FZ5; O75459: PAGE1; NbExp=3; IntAct=EBI-2807956, EBI-2559100;
CC Q96FZ5; Q8IYJ0: PIANP; NbExp=3; IntAct=EBI-2807956, EBI-12204277;
CC Q96FZ5; Q15008: PSMD6; NbExp=3; IntAct=EBI-2807956, EBI-359701;
CC Q96FZ5; Q86VR2: RETREG3; NbExp=5; IntAct=EBI-2807956, EBI-10192441;
CC Q96FZ5; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-2807956, EBI-10204280;
CC Q96FZ5; A0PJX4: SHISA3; NbExp=3; IntAct=EBI-2807956, EBI-10171518;
CC Q96FZ5; Q15849: SLC14A2; NbExp=3; IntAct=EBI-2807956, EBI-1573290;
CC Q96FZ5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-2807956, EBI-10262251;
CC Q96FZ5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2807956, EBI-17280858;
CC Q96FZ5; Q16623: STX1A; NbExp=3; IntAct=EBI-2807956, EBI-712466;
CC Q96FZ5; P57738: TCTA; NbExp=3; IntAct=EBI-2807956, EBI-6447595;
CC Q96FZ5; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-2807956, EBI-19027521;
CC Q96FZ5; Q8WY91: THAP4; NbExp=3; IntAct=EBI-2807956, EBI-726691;
CC Q96FZ5; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-2807956, EBI-2821497;
CC Q96FZ5; Q8WUU8: TMEM174; NbExp=4; IntAct=EBI-2807956, EBI-10276729;
CC Q96FZ5; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-2807956, EBI-12345267;
CC Q96FZ5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2807956, EBI-6447886;
CC Q96FZ5; Q02223: TNFRSF17; NbExp=3; IntAct=EBI-2807956, EBI-519945;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96FZ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96FZ5-2; Sequence=VSP_042566;
CC -!- TISSUE SPECIFICITY: Highly expressed in leukocytes.
CC {ECO:0000269|PubMed:12782130}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF479263; AAN73041.1; -; mRNA.
DR EMBL; DQ132881; AAZ57435.1; -; mRNA.
DR EMBL; AY174113; AAO44955.1; -; mRNA.
DR EMBL; AC098475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010116; AAH10116.1; -; mRNA.
DR CCDS; CCDS33730.1; -. [Q96FZ5-1]
DR CCDS; CCDS33731.1; -. [Q96FZ5-2]
DR RefSeq; NP_612419.1; NM_138410.3. [Q96FZ5-1]
DR RefSeq; NP_852137.1; NM_181472.2. [Q96FZ5-2]
DR AlphaFoldDB; Q96FZ5; -.
DR BioGRID; 125197; 47.
DR IntAct; Q96FZ5; 46.
DR STRING; 9606.ENSP00000335605; -.
DR TCDB; 1.A.64.5.1; the plasmolipin (plasmolipin) family.
DR iPTMnet; Q96FZ5; -.
DR PhosphoSitePlus; Q96FZ5; -.
DR SwissPalm; Q96FZ5; -.
DR BioMuta; CMTM7; -.
DR DMDM; 34922026; -.
DR EPD; Q96FZ5; -.
DR jPOST; Q96FZ5; -.
DR MassIVE; Q96FZ5; -.
DR MaxQB; Q96FZ5; -.
DR PaxDb; Q96FZ5; -.
DR PeptideAtlas; Q96FZ5; -.
DR PRIDE; Q96FZ5; -.
DR ProteomicsDB; 76574; -. [Q96FZ5-1]
DR ProteomicsDB; 76575; -. [Q96FZ5-2]
DR Antibodypedia; 27737; 137 antibodies from 22 providers.
DR DNASU; 112616; -.
DR Ensembl; ENST00000334983.10; ENSP00000335605.5; ENSG00000153551.14. [Q96FZ5-1]
DR Ensembl; ENST00000349718.8; ENSP00000283621.5; ENSG00000153551.14. [Q96FZ5-2]
DR GeneID; 112616; -.
DR KEGG; hsa:112616; -.
DR MANE-Select; ENST00000334983.10; ENSP00000335605.5; NM_138410.4; NP_612419.1.
DR UCSC; uc003cey.2; human. [Q96FZ5-1]
DR CTD; 112616; -.
DR DisGeNET; 112616; -.
DR GeneCards; CMTM7; -.
DR HGNC; HGNC:19178; CMTM7.
DR HPA; ENSG00000153551; Low tissue specificity.
DR MIM; 607890; gene.
DR neXtProt; NX_Q96FZ5; -.
DR OpenTargets; ENSG00000153551; -.
DR PharmGKB; PA38817; -.
DR VEuPathDB; HostDB:ENSG00000153551; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00510000048725; -.
DR HOGENOM; CLU_127424_0_0_1; -.
DR InParanoid; Q96FZ5; -.
DR OMA; IWLSYKV; -.
DR OrthoDB; 1520058at2759; -.
DR PhylomeDB; Q96FZ5; -.
DR TreeFam; TF317387; -.
DR PathwayCommons; Q96FZ5; -.
DR SignaLink; Q96FZ5; -.
DR BioGRID-ORCS; 112616; 16 hits in 1075 CRISPR screens.
DR ChiTaRS; CMTM7; human.
DR GenomeRNAi; 112616; -.
DR Pharos; Q96FZ5; Tbio.
DR PRO; PR:Q96FZ5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96FZ5; protein.
DR Bgee; ENSG00000153551; Expressed in granulocyte and 150 other tissues.
DR ExpressionAtlas; Q96FZ5; baseline and differential.
DR Genevisible; Q96FZ5; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0002337; P:B-1a B cell differentiation; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..175
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 7"
FT /id="PRO_0000186110"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 40..166
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 112..144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12782130, ECO:0000303|Ref.2"
FT /id="VSP_042566"
SQ SEQUENCE 175 AA; 18834 MW; 4EF44A5738C41F60 CRC64;
MSHGAGLVRT TCSSGSALGP GAGAAQPSAS PLEGLLDLSY PRTHAALLKV AQMVTLLIAF
ICVRSSLWTN YSAYSYFEVV TICDLIMILA FYLVHLFRFY RVLTCISWPL SELLHYLIGT
LLLLIASIVA ASKSYNQSGL VAGAIFGFMA TFLCMASIWL SYKISCVTQS TDAAV
