CKLF7_MOUSE
ID CKLF7_MOUSE Reviewed; 167 AA.
AC Q9ESD6; Q8CHW2;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 7;
DE AltName: Full=Chemokine-like factor superfamily member 7;
DE AltName: Full=LNV;
GN Name=Cmtm7; Synonyms=Cklfsf7, Lnv;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wang J.W., Tu Z., Kerr W.G.;
RT "Cloning and characterization of a novel gene Lnv that is LPS-responsive in
RT B cells and associated with the nuclear membrane and vesicles.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Thymus;
RA Han W., Li T., Tan Y., Shi S., Ding P., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ESD6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ESD6-2; Sequence=VSP_008267;
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF188504; AAG15398.1; -; mRNA.
DR EMBL; AY241869; AAP33491.1; -; mRNA.
DR EMBL; BC038633; AAH38633.1; -; mRNA.
DR CCDS; CCDS57709.1; -. [Q9ESD6-2]
DR CCDS; CCDS57710.1; -. [Q9ESD6-1]
DR RefSeq; NP_001239408.1; NM_001252479.1. [Q9ESD6-2]
DR RefSeq; NP_598739.1; NM_133978.2. [Q9ESD6-1]
DR AlphaFoldDB; Q9ESD6; -.
DR BioGRID; 221896; 2.
DR STRING; 10090.ENSMUSP00000035009; -.
DR iPTMnet; Q9ESD6; -.
DR PhosphoSitePlus; Q9ESD6; -.
DR SwissPalm; Q9ESD6; -.
DR EPD; Q9ESD6; -.
DR MaxQB; Q9ESD6; -.
DR PaxDb; Q9ESD6; -.
DR PRIDE; Q9ESD6; -.
DR ProteomicsDB; 283509; -. [Q9ESD6-1]
DR ProteomicsDB; 283510; -. [Q9ESD6-2]
DR Antibodypedia; 27737; 137 antibodies from 22 providers.
DR DNASU; 102545; -.
DR Ensembl; ENSMUST00000035009; ENSMUSP00000035009; ENSMUSG00000032436. [Q9ESD6-1]
DR Ensembl; ENSMUST00000084867; ENSMUSP00000081927; ENSMUSG00000032436. [Q9ESD6-2]
DR GeneID; 102545; -.
DR KEGG; mmu:102545; -.
DR UCSC; uc009ryc.2; mouse. [Q9ESD6-1]
DR UCSC; uc009ryd.2; mouse. [Q9ESD6-2]
DR CTD; 112616; -.
DR MGI; MGI:2447166; Cmtm7.
DR VEuPathDB; HostDB:ENSMUSG00000032436; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00510000048725; -.
DR HOGENOM; CLU_127424_0_0_1; -.
DR InParanoid; Q9ESD6; -.
DR OMA; IWLSYKV; -.
DR OrthoDB; 1520058at2759; -.
DR PhylomeDB; Q9ESD6; -.
DR TreeFam; TF317387; -.
DR BioGRID-ORCS; 102545; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Cmtm7; mouse.
DR PRO; PR:Q9ESD6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9ESD6; protein.
DR Bgee; ENSMUSG00000032436; Expressed in granulocyte and 206 other tissues.
DR ExpressionAtlas; Q9ESD6; baseline and differential.
DR Genevisible; Q9ESD6; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0002337; P:B-1a B cell differentiation; IMP:MGI.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 7"
FT /id="PRO_0000186111"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..158
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 104..136
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_008267"
SQ SEQUENCE 167 AA; 18105 MW; 1F97D2D03626975E CRC64;
MSHGSGLVRT TCSSGGALGP GQPSEGLLDR VYPLTHGALF KVAQMVTLLI AFICVRSSVP
IDYGAHSFFE VVTMCDLIMI LIFYLVHLFR FYRVLTCISW PLSELLHYLI GTLLLLIASI
VIASKSYNQS GLVAGAIFGF LASFLCLASL WLSYKITCIT QSSDASA
