ID   CKLF8_BOVIN             Reviewed;         173 AA.
AC   Q1RMP9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 8;
DE   AltName: Full=Chemokine-like factor superfamily member 8;
GN   Name=CMTM8; Synonyms=CKLFSF8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR   EMBL; BC114787; AAI14788.1; -; mRNA.
DR   RefSeq; NP_001039823.1; NM_001046358.1.
DR   AlphaFoldDB; Q1RMP9; -.
DR   STRING; 9913.ENSBTAP00000002237; -.
DR   PaxDb; Q1RMP9; -.
DR   Ensembl; ENSBTAT00000002237; ENSBTAP00000002237; ENSBTAG00000001710.
DR   GeneID; 533671; -.
DR   KEGG; bta:533671; -.
DR   CTD; 152189; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001710; -.
DR   VGNC; VGNC:27488; CMTM8.
DR   eggNOG; KOG4788; Eukaryota.
DR   GeneTree; ENSGT00940000160520; -.
DR   HOGENOM; CLU_103581_1_0_1; -.
DR   InParanoid; Q1RMP9; -.
DR   OMA; CYAGNAY; -.
DR   OrthoDB; 1455336at2759; -.
DR   TreeFam; TF316174; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000001710; Expressed in olfactory segment of nasal mucosa and 110 other tissues.
DR   ExpressionAtlas; Q1RMP9; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   InterPro; IPR013295; MAL.
DR   InterPro; IPR008253; Marvel.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR01884; MALPROTEIN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..173
FT                   /note="CKLF-like MARVEL transmembrane domain-containing
FT                   protein 8"
FT                   /id="PRO_0000332211"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..168
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ   SEQUENCE   173 AA;  19629 MW;  832A9B81324B874B CRC64;
     MEEPQRARSQ TVTTTASSFA ENFSTTSSSF SYDREFLRTL PGLLIVAEIV LGLLVWTLIA
     GTEYFRVPAF GWVMFVAVFY WVLTVFFLII YLTMTYTRIP QVPWTTVGLW FNGSAFALYL
     SAAIVDASSV SPERDSHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TIQ