CKLF8_HUMAN
ID CKLF8_HUMAN Reviewed; 173 AA.
AC Q8IZV2; A5D6I7; Q8IW01;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 8;
DE AltName: Full=Chemokine-like factor superfamily member 8;
GN Name=CMTM8; Synonyms=CKLFSF8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Tonsil;
RX PubMed=12782130; DOI=10.1016/s0888-7543(03)00095-8;
RA Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y.,
RA Yang T., Ma D.;
RT "Identification of eight genes encoding chemokine-like factor superfamily
RT members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.";
RL Genomics 81:609-617(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Blood;
RX PubMed=17681841; DOI=10.1016/j.biocel.2007.06.002;
RA Li D., Jin C., Yin C., Zhang Y., Pang B., Tian L., Han W., Ma D., Wang Y.;
RT "An alternative splice form of CMTM8 induces apoptosis.";
RL Int. J. Biochem. Cell Biol. 39:2107-2119(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q8IZV2; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-7868911, EBI-11749135;
CC Q8IZV2; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-7868911, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Multi-pass membrane
CC protein.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IZV2-1; Sequence=Displayed;
CC Name=2; Synonyms=CMTM8-v2;
CC IsoId=Q8IZV2-2; Sequence=VSP_044430;
CC -!- TISSUE SPECIFICITY: Highly expressed in liver and pancreas.
CC {ECO:0000269|PubMed:12782130}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AF474370; AAN73034.1; -; mRNA.
DR EMBL; AY598783; AAT11020.1; -; mRNA.
DR EMBL; AC097639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC103558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041390; AAH41390.1; -; mRNA.
DR CCDS; CCDS2652.1; -. [Q8IZV2-1]
DR CCDS; CCDS82753.1; -. [Q8IZV2-2]
DR RefSeq; NP_001307237.1; NM_001320308.1. [Q8IZV2-2]
DR RefSeq; NP_849199.2; NM_178868.4. [Q8IZV2-1]
DR AlphaFoldDB; Q8IZV2; -.
DR BioGRID; 127434; 83.
DR IntAct; Q8IZV2; 2.
DR MINT; Q8IZV2; -.
DR STRING; 9606.ENSP00000307741; -.
DR iPTMnet; Q8IZV2; -.
DR PhosphoSitePlus; Q8IZV2; -.
DR BioMuta; CMTM8; -.
DR DMDM; 145559454; -.
DR EPD; Q8IZV2; -.
DR jPOST; Q8IZV2; -.
DR MassIVE; Q8IZV2; -.
DR MaxQB; Q8IZV2; -.
DR PaxDb; Q8IZV2; -.
DR PeptideAtlas; Q8IZV2; -.
DR PRIDE; Q8IZV2; -.
DR ProteomicsDB; 706; -.
DR ProteomicsDB; 71435; -. [Q8IZV2-1]
DR Antibodypedia; 27732; 150 antibodies from 25 providers.
DR DNASU; 152189; -.
DR Ensembl; ENST00000307526.4; ENSP00000307741.3; ENSG00000170293.9. [Q8IZV2-1]
DR Ensembl; ENST00000458535.6; ENSP00000412934.2; ENSG00000170293.9. [Q8IZV2-2]
DR GeneID; 152189; -.
DR KEGG; hsa:152189; -.
DR MANE-Select; ENST00000307526.4; ENSP00000307741.3; NM_178868.5; NP_849199.2.
DR UCSC; uc003cex.4; human. [Q8IZV2-1]
DR CTD; 152189; -.
DR DisGeNET; 152189; -.
DR GeneCards; CMTM8; -.
DR HGNC; HGNC:19179; CMTM8.
DR HPA; ENSG00000170293; Tissue enhanced (pancreas).
DR MIM; 607891; gene.
DR neXtProt; NX_Q8IZV2; -.
DR OpenTargets; ENSG00000170293; -.
DR PharmGKB; PA38818; -.
DR VEuPathDB; HostDB:ENSG00000170293; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000160520; -.
DR HOGENOM; CLU_2108188_0_0_1; -.
DR InParanoid; Q8IZV2; -.
DR OMA; CYAGNAY; -.
DR OrthoDB; 1455336at2759; -.
DR PhylomeDB; Q8IZV2; -.
DR TreeFam; TF316174; -.
DR PathwayCommons; Q8IZV2; -.
DR SignaLink; Q8IZV2; -.
DR BioGRID-ORCS; 152189; 17 hits in 1073 CRISPR screens.
DR ChiTaRS; CMTM8; human.
DR GenomeRNAi; 152189; -.
DR Pharos; Q8IZV2; Tbio.
DR PRO; PR:Q8IZV2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8IZV2; protein.
DR Bgee; ENSG00000170293; Expressed in secondary oocyte and 134 other tissues.
DR Genevisible; Q8IZV2; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chemotaxis; Cytokine; Cytoplasm; Membrane; Nucleus;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..173
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 8"
FT /id="PRO_0000186112"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 36..168
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 50..107
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17681841"
FT /id="VSP_044430"
FT CONFLICT 24
FT /note="S -> F (in Ref. 1; AAN73034)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="P -> H (in Ref. 4; AAH41390)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="F -> S (in Ref. 4; AAH41390)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 19572 MW; 30566423F2A6F600 CRC64;
MEEPQRARSH TVTTTASSFA ENFSTSSSSF AYDREFLRTL PGFLIVAEIV LGLLVWTLIA
GTEYFRVPAF GWVMFVAVFY WVLTVFFLII YITMTYTRIP QVPWTTVGLC FNGSAFVLYL
SAAVVDASSV SPERDSHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TIQ
