CKLF8_MOUSE
ID CKLF8_MOUSE Reviewed; 173 AA.
AC Q9CZR4;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 8;
DE AltName: Full=Chemokine-like factor superfamily member 8;
GN Name=Cmtm8; Synonyms=Cklfsf8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Leukocyte;
RA Ding P., Han W., Li T., Yang T., Shi S., Tan Y., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AY243513; AAO89236.1; -; mRNA.
DR EMBL; AK012262; BAB28125.1; -; mRNA.
DR EMBL; BC027554; AAH27554.1; -; mRNA.
DR CCDS; CCDS23597.1; -.
DR RefSeq; NP_081570.1; NM_027294.2.
DR AlphaFoldDB; Q9CZR4; -.
DR STRING; 10090.ENSMUSP00000043706; -.
DR iPTMnet; Q9CZR4; -.
DR PhosphoSitePlus; Q9CZR4; -.
DR PaxDb; Q9CZR4; -.
DR PRIDE; Q9CZR4; -.
DR ProteomicsDB; 283627; -.
DR Antibodypedia; 27732; 150 antibodies from 25 providers.
DR DNASU; 70031; -.
DR Ensembl; ENSMUST00000047013; ENSMUSP00000043706; ENSMUSG00000041012.
DR GeneID; 70031; -.
DR KEGG; mmu:70031; -.
DR UCSC; uc009ryg.1; mouse.
DR CTD; 152189; -.
DR MGI; MGI:2447167; Cmtm8.
DR VEuPathDB; HostDB:ENSMUSG00000041012; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000160520; -.
DR HOGENOM; CLU_103581_1_0_1; -.
DR InParanoid; Q9CZR4; -.
DR OMA; CYAGNAY; -.
DR OrthoDB; 1455336at2759; -.
DR PhylomeDB; Q9CZR4; -.
DR TreeFam; TF316174; -.
DR BioGRID-ORCS; 70031; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cmtm8; mouse.
DR PRO; PR:Q9CZR4; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9CZR4; protein.
DR Bgee; ENSMUSG00000041012; Expressed in left lobe of liver and 170 other tissues.
DR Genevisible; Q9CZR4; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..173
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 8"
FT /id="PRO_0000186113"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 36..168
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 173 AA; 19527 MW; B58E8E5C0E8539A1 CRC64;
MEEQQRARSH TVTTTTSSFA ENFSTTSSSF AYDREFLRTP PGLLIVAEIV LGLLVWTLIA
GTEYFRVPAF GWVMFVAVFY WVLTVFFLIV YITLTYTRIP QVPWTTVGLC FNGSAFVLYF
SAAIVDASSV SPEKEGHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TAQ
