CKLF_RAT
ID CKLF_RAT Reviewed; 151 AA.
AC Q9JK79; Q9JK80;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Chemokine-like factor;
GN Name=Cklf; Synonyms=Cklf1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|EMBL:AAF69503.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CKLF1 AND CKLF2), FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Wistar {ECO:0000269|PubMed:12706894};
RC TISSUE=Liver {ECO:0000269|PubMed:12706894};
RX PubMed=12706894; DOI=10.1016/s0378-1119(03)00450-5;
RA Lou Y., Xia D., Han W., Wang Y., Li X., Li Y., Rui M., Ding P., Song Q.,
RA Zhang Y., Ma D.;
RT "Molecular cloning and characterization of rat chemokine-like factor 1 and
RT 2.";
RL Gene 307:125-132(2003).
CC -!- FUNCTION: May play an important role in inflammation and regeneration
CC of skeletal muscle (By similarity). Essential for embryonic development
CC (By similarity). {ECO:0000250|UniProtKB:Q9DAS1,
CC ECO:0000250|UniProtKB:Q9UBR5}.
CC -!- FUNCTION: [Isoform CKLF1]: Has chemotactic response in monocytes,
CC neutrophils and lymphocytes (PubMed:12706894). Binds CCR4 (By
CC similarity). {ECO:0000250|UniProtKB:Q9UBR5,
CC ECO:0000269|PubMed:12706894}.
CC -!- SUBCELLULAR LOCATION: [Isoform CKLF1]: Secreted
CC {ECO:0000250|UniProtKB:Q9UBR5}.
CC -!- SUBCELLULAR LOCATION: [Isoform CKLF2]: Membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=CKLF2 {ECO:0000269|PubMed:12706894};
CC IsoId=Q9JK79-1; Sequence=Displayed;
CC Name=CKLF1 {ECO:0000269|PubMed:12706894};
CC IsoId=Q9JK79-2; Sequence=VSP_050604;
CC -!- TISSUE SPECIFICITY: Both isoforms have highest expression levels in
CC testis with relatively lower expression level in liver, spleen, lung,
CC brain and heart and barely detectable levels in skeletal muscle and
CC kidney were barely detected. In most tissues, isoform CKLF2 has higher
CC expression levels than isoform CKLF1. {ECO:0000269|PubMed:12706894}.
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF253064; AAF69502.1; -; mRNA.
DR EMBL; AF253065; AAF69503.1; -; mRNA.
DR RefSeq; NP_620811.1; NM_139111.1. [Q9JK79-1]
DR AlphaFoldDB; Q9JK79; -.
DR STRING; 10116.ENSRNOP00000017127; -.
DR GlyGen; Q9JK79; 1 site.
DR PaxDb; Q9JK79; -.
DR Ensembl; ENSRNOT00000017127; ENSRNOP00000017127; ENSRNOG00000012752. [Q9JK79-1]
DR Ensembl; ENSRNOT00000106021; ENSRNOP00000085854; ENSRNOG00000012752. [Q9JK79-2]
DR GeneID; 245978; -.
DR KEGG; rno:245978; -.
DR UCSC; RGD:620708; rat. [Q9JK79-1]
DR CTD; 51192; -.
DR RGD; 620708; Cklf.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000162264; -.
DR HOGENOM; CLU_108546_3_0_1; -.
DR InParanoid; Q9JK79; -.
DR OMA; CCSVKGH; -.
DR OrthoDB; 1423020at2759; -.
DR PhylomeDB; Q9JK79; -.
DR TreeFam; TF317387; -.
DR PRO; PR:Q9JK79; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000012752; Expressed in testis and 19 other tissues.
DR Genevisible; Q9JK79; RN.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0008009; F:chemokine activity; ISO:RGD.
DR GO; GO:0030595; P:leukocyte chemotaxis; IDA:RGD.
DR GO; GO:0048247; P:lymphocyte chemotaxis; ISO:RGD.
DR GO; GO:0048246; P:macrophage chemotaxis; ISO:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; IDA:RGD.
DR GO; GO:0032940; P:secretion by cell; ISO:RGD.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chemotaxis; Cytokine; Glycoprotein; Membrane;
KW Reference proteome; Secreted; Transmembrane; Transmembrane helix.
FT CHAIN 1..151
FT /note="Chemokine-like factor"
FT /id="PRO_0000186096"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 13..133
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 26..78
FT /note="Missing (in isoform CKLF1)"
FT /evidence="ECO:0000303|PubMed:12706894"
FT /id="VSP_050604"
SQ SEQUENCE 151 AA; 16855 MW; BBBD6E9B7C0D86F4 CRC64;
MDSPQKVVDH QPFCLSLKCF VKTLRLVVTV ASMIFFIVAQ APEPYIVITG FEVTIILFLI
ALYMCSLDKT MRSFFWPLLD VINSVVTTLF MLIVSVSALI PETSTMIMVG GVFGFLTVIC
TVADCALMCQ KLRFRPHGPY QNRSATDVDD S
