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CKN1_SCHPO
ID   CKN1_SCHPO              Reviewed;         404 AA.
AC   Q9USR0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=DNA excision repair protein ckn1;
GN   Name=ckn1; ORFNames=SPBC577.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   FUNCTION, DOMAIN, AND INTERACTION WITH DDB1.
RX   PubMed=18794354; DOI=10.1128/mcb.00757-08;
RA   Fukumoto Y., Dohmae N., Hanaoka F.;
RT   "Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor
RT   proteins through a novel protein motif, the DDB-box.";
RL   Mol. Cell. Biol. 28:6746-6756(2008).
CC   -!- FUNCTION: Adapter protein for ddb1/cullin 4 ubiquitin ligases involved
CC       in transcription-coupled nucleotide excision repair.
CC       {ECO:0000269|PubMed:18794354}.
CC   -!- SUBUNIT: Interacts with ddb1. {ECO:0000269|PubMed:18794354}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- DOMAIN: The DDB-box is specifically required for ddb1-binding.
CC       {ECO:0000269|PubMed:18794354}.
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DR   EMBL; CU329671; CAB54817.1; -; Genomic_DNA.
DR   PIR; T40553; T40553.
DR   RefSeq; NP_595307.1; NM_001021214.2.
DR   AlphaFoldDB; Q9USR0; -.
DR   SMR; Q9USR0; -.
DR   BioGRID; 277378; 2.
DR   STRING; 4896.SPBC577.09.1; -.
DR   PaxDb; Q9USR0; -.
DR   EnsemblFungi; SPBC577.09.1; SPBC577.09.1:pep; SPBC577.09.
DR   GeneID; 2540861; -.
DR   KEGG; spo:SPBC577.09; -.
DR   PomBase; SPBC577.09; ckn1.
DR   VEuPathDB; FungiDB:SPBC577.09; -.
DR   eggNOG; KOG4283; Eukaryota.
DR   HOGENOM; CLU_032951_2_1_1; -.
DR   InParanoid; Q9USR0; -.
DR   OMA; MTAVKAF; -.
DR   PhylomeDB; Q9USR0; -.
DR   Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-SPO-6782135; Dual incision in TC-NER.
DR   Reactome; R-SPO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-SPO-8951664; Neddylation.
DR   PRO; PR:Q9USR0; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0031464; C:Cul4A-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0070912; C:Ddb1-Ckn1 complex; IDA:PomBase.
DR   GO; GO:0000109; C:nucleotide-excision repair complex; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:PomBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR042238; Rad28/ERCC8/Ckn1/ATCSA-1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR46202; PTHR46202; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA damage; DNA repair; Reference proteome; Repeat;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..404
FT                   /note="DNA excision repair protein ckn1"
FT                   /id="PRO_0000316565"
FT   REPEAT          45..85
FT                   /note="WD 1"
FT   REPEAT          101..141
FT                   /note="WD 2"
FT   REPEAT          187..227
FT                   /note="WD 3"
FT   REPEAT          244..283
FT                   /note="WD 4"
FT   REPEAT          339..378
FT                   /note="WD 5"
FT   MOTIF           1..19
FT                   /note="DDB-box"
SQ   SEQUENCE   404 AA;  45541 MW;  799D78D76036017B CRC64;
     MNSFLLAREW GQEPNSSFRR QLLQHRLQRL ALNPDVKIKR RHGAGILGSV NALSIDNTIH
     QLMVSGGANS SINVWDLQNI DQKEDEDLIL DTLNAVPART SHKFGITDLH WFPFDNGIFT
     SSSFDHTLKV WDVSTLQEAY TFTMEDMIYS HAWSPIASHC LIATAYRSSS IRLCDMQSGS
     YTHSLSGHTG NVLAVDWCPK NEFVLASGSA DGTCRLWDIR KVSSSFACMD LHNKYLPSNQ
     TNISHYGTVN GLAWTSDARY LASCGTDDRI RVWNMESGRN TLREFGPIIH NQTTSFAVHP
     CMIQPSMDSD VFVLFPNDDG SLALLNLLEG SFVRRLSTHS LKRINCAAYR PDFEQCFTGD
     MNGNIYMWSP KALKSPTKIS DLETRRNIIQ EVYDSLINIP VTYQ
 
 
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