ID   CKNA_CONIM              Reviewed;          72 AA.
AC   A0A125S9E4;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin Im23a {ECO:0000305};
DE   AltName: Full=Conopeptide im010 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17668.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is XXIII (C-C-C-CC-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin K superfamily. {ECO:0000305}.
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DR   EMBL; KT377404; AME17668.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9E4; -.
DR   SMR; A0A125S9E4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..30
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000451000"
FT   CHAIN           31..72
FT                   /note="Conotoxin Im23a"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179752"
FT   DISULFID        34..41
FT                   /evidence="ECO:0000250|UniProtKB:D0PX84"
FT   DISULFID        45..55
FT                   /evidence="ECO:0000250|UniProtKB:D0PX84"
FT   DISULFID        56..71
FT                   /evidence="ECO:0000250|UniProtKB:D0PX84"
SQ   SEQUENCE   72 AA;  8040 MW;  F906BE740065B2C4 CRC64;
     MIMRMTLTLF VLVVMTAASA SGDALTEAKR IPYCGQTGAE CYSWCIKQDL SKDWCCDFVK
     DIRMNPPADK CP