ID   CKQ_CONQU               Reviewed;          17 AA.
AC   P0DOZ4;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Conantokin-Qu {ECO:0000303|PubMed:17153339};
DE            Short=Con-Qu {ECO:0000303|PubMed:17153339};
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   REVIEW, AND GAMMA-CARBOXYGLUTAMATION AT GLU-3; GLU-4; GLU-6; GLU-9 AND
RP   GLU-13.
RX   PubMed=17153339; DOI=10.1007/978-3-540-30880-5_4;
RA   Franco A., Pisarewicz K., Moller C., Mora D., Fields G.B., Mari F.;
RT   "Hyperhydroxylation: a new strategy for neuronal targeting by venomous
RT   marine molluscs.";
RL   Prog. Mol. Subcell. Biol. 43:83-103(2006).
CC   -!- FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DOZ4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Gamma-carboxyglutamic acid; Ion channel impairing toxin;
KW   Ionotropic glutamate receptor inhibitor; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..17
FT                   /note="Conantokin-Qu"
FT                   /id="PRO_0000439371"
FT   MOD_RES         3
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:17153339"
FT   MOD_RES         4
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:17153339"
FT   MOD_RES         6
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:17153339"
FT   MOD_RES         9
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:17153339"
FT   MOD_RES         13
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:17153339"
SQ   SEQUENCE   17 AA;  1937 MW;  B4B0CD7C7DCB568E CRC64;
     GYEEREVAET VRELDAA