ID   CKR1_CHICK              Reviewed;         509 AA.
AC   P30373;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Zinc finger protein CKR1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=1840543; DOI=10.1016/0378-1119(91)90200-u;
RA   Benn A., Antoine M., Beug H., Niessing J.;
RT   "Primary structure and expression of a chicken cDNA encoding a protein with
RT   zinc-finger motifs.";
RL   Gene 106:207-212(1991).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; X15538; CAA33545.1; -; mRNA.
DR   PIR; JH0501; JH0501.
DR   AlphaFoldDB; P30373; -.
DR   SMR; P30373; -.
DR   PRIDE; P30373; -.
DR   VEuPathDB; HostDB:geneid_396247; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   PhylomeDB; P30373; -.
DR   PRO; PR:P30373; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..509
FT                   /note="Zinc finger protein CKR1"
FT                   /id="PRO_0000047587"
FT   DOMAIN          1..61
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         113..135
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         141..163
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         169..191
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         197..219
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         225..247
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         279..303
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         303..325
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         331..353
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         359..383
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         387..409
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         415..437
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          41..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  56709 MW;  04EA1695F2DC36F8 CRC64;
     MEPYVLLDPR QKALYRDVMQ ESYETLMSIA QGLVNHKAAE EDAVGLKEDA VGSEEPQTHP
     PHNPAQNRTA GSHRRKAKRP DKAAPLGVAQ TPPAAPTPKR DGVKPSRVRD RPFGCPDCGK
     SFPWASHLER HRRVHTGERP YSCPECGESY SQSSHLVQHR RTHGGDRPHK CQHCGKPFAG
     AAQLLAHSRG HAADRPHRCG DCGKGFVWAS HLERHRRVHT GEKPYECPEC GEAFSQGSHL
     TKHRRSHARS GRTAAPLRKC FGQSSDLVQH RSRAGKKPQR CAECGKAFRA APPLRRHRRE
     RSHRCGDCGK GFAWASHLQR HRRVHTGERP FPCGLCGERF SQKAHLLQHG KTHRPERPYK
     CGDCGKRFEN APPFLAHRRG HAALKSFTCG DCGKGFAWAS HLQRHRRVHT GEKPYECPEC
     GEAFSQGSHL TKHRRSHGPK APLLPVQGRG EAGEPLRASP LSSGAEQRDG RRAQRGGVEE
     EVGWGANRAV LRGRSAHSWP RSHLPMLGC