ID   CKS1_BOVIN              Reviewed;          79 AA.
AC   Q0P5A5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Cyclin-dependent kinases regulatory subunit 1;
DE            Short=CKS-1;
GN   Name=CKS1B; Synonyms=CKS1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Placenta;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC       kinases and is essential for their biological function. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CKS family. {ECO:0000305}.
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DR   EMBL; BC120301; AAI20302.1; -; mRNA.
DR   RefSeq; NP_001106782.1; NM_001113311.1.
DR   AlphaFoldDB; Q0P5A5; -.
DR   SMR; Q0P5A5; -.
DR   STRING; 9913.ENSBTAP00000033878; -.
DR   PaxDb; Q0P5A5; -.
DR   PRIDE; Q0P5A5; -.
DR   Ensembl; ENSBTAT00000033975; ENSBTAP00000033878; ENSBTAG00000024476.
DR   GeneID; 615827; -.
DR   KEGG; bta:615827; -.
DR   CTD; 1163; -.
DR   VEuPathDB; HostDB:ENSBTAG00000024476; -.
DR   VGNC; VGNC:27387; CKS1B.
DR   eggNOG; KOG3484; Eukaryota.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_140546_2_0_1; -.
DR   InParanoid; Q0P5A5; -.
DR   OMA; NPEPHVL; -.
DR   OrthoDB; 1377855at2759; -.
DR   TreeFam; TF101142; -.
DR   Reactome; R-BTA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-BTA-69231; Cyclin D associated events in G1.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000024476; Expressed in oocyte and 109 other tissues.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:Ensembl.
DR   Gene3D; 3.30.170.10; -; 1.
DR   InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR   InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR   Pfam; PF01111; CKS; 1.
DR   PRINTS; PR00296; CYCLINKINASE.
DR   SMART; SM01084; CKS; 1.
DR   SUPFAM; SSF55637; SSF55637; 1.
DR   PROSITE; PS00944; CKS_1; 1.
DR   PROSITE; PS00945; CKS_2; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell cycle; Cell division; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P61024"
FT   CHAIN           2..79
FT                   /note="Cyclin-dependent kinases regulatory subunit 1"
FT                   /id="PRO_0000260446"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61024"
SQ   SEQUENCE   79 AA;  9660 MW;  E64207B140FA38D5 CRC64;
     MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ SQGWVHYMIH
     EPEPHILLFR RPLPKKPKK