ID   CKS1_CAEBR              Reviewed;          94 AA.
AC   A8XMF2;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Cyclin-dependent kinases regulatory subunit {ECO:0000250|UniProtKB:Q17868};
GN   Name=cks-1 {ECO:0000312|EMBL:CAP33828.1}; ORFNames=CBG15632;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP33828.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP33828.1};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC       kinases and is essential for their biological function. Has a role in
CC       the exit from M phase during early mitotic cell division. More
CC       specifically, thought to act by the degrading B-type cyclins that
CC       causes breakdown of nuclear envelope and exit mitosis (By similarity).
CC       {ECO:0000250|UniProtKB:Q17868}.
CC   -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC       subunits. Interacts with cdk-1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CKS family. {ECO:0000255}.
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DR   EMBL; HE600937; CAP33828.1; -; Genomic_DNA.
DR   RefSeq; XP_002640765.1; XM_002640719.1.
DR   AlphaFoldDB; A8XMF2; -.
DR   SMR; A8XMF2; -.
DR   STRING; 6238.CBG15632; -.
DR   EnsemblMetazoa; CBG15632.1; CBG15632.1; WBGene00035798.
DR   GeneID; 8582759; -.
DR   KEGG; cbr:CBG_15632; -.
DR   CTD; 8582759; -.
DR   WormBase; CBG15632; CBP03784; WBGene00035798; Cbr-cks-1.
DR   eggNOG; KOG3484; Eukaryota.
DR   HOGENOM; CLU_140546_2_0_1; -.
DR   InParanoid; A8XMF2; -.
DR   OMA; PREMTKY; -.
DR   OrthoDB; 1377855at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0009794; P:regulation of mitotic cell cycle, embryonic; ISS:UniProtKB.
DR   Gene3D; 3.30.170.10; -; 1.
DR   InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR   InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR   Pfam; PF01111; CKS; 1.
DR   PRINTS; PR00296; CYCLINKINASE.
DR   SMART; SM01084; CKS; 1.
DR   SUPFAM; SSF55637; SSF55637; 1.
DR   PROSITE; PS00944; CKS_1; 1.
DR   PROSITE; PS00945; CKS_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..94
FT                   /note="Cyclin-dependent kinases regulatory subunit"
FT                   /id="PRO_0000353200"
SQ   SEQUENCE   94 AA;  10876 MW;  DD8A03D2EBF91092 CRC64;
     MTTGSNDFYY SNKYEDDEYE YRHVHVTKDV AKLIPKNRLM SETEWRSLGI QQSPGWIHYM
     IHGPERHVLL FRRPLPNAQK TVRGGGGTSA VGVR