CKS1_CAEEL
ID CKS1_CAEEL Reviewed; 94 AA.
AC Q17868;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Cyclin-dependent kinases regulatory subunit;
GN Name=cks-1; Synonyms=dom-6; ORFNames=C09G4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9609830; DOI=10.1242/dev.125.13.2469;
RA Korf I., Fan Y., Strome S.;
RT "The polycomb group in Caenorhabditis elegans and maternal control of
RT germline development.";
RL Development 125:2469-2478(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11102813; DOI=10.1016/s0960-9822(00)00808-3;
RA Polinko E.S., Strome S.;
RT "Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase
RT role in both meiosis and mitosis.";
RL Curr. Biol. 10:1471-1474(2000).
RN [4]
RP FUNCTION, INTERACTION WITH CDK-1, AND MUTAGENESIS OF TYR-10.
RX PubMed=16343905; DOI=10.1016/j.cub.2005.11.070;
RA Shirayama M., Soto M.C., Ishidate T., Kim S., Nakamura K., Bei Y.,
RA van den Heuvel S., Mello C.C.;
RT "The conserved kinases CDK-1, GSK-3, KIN-19, and MBK-2 promote OMA-1
RT destruction to regulate the oocyte-to-embryo transition in C. elegans.";
RL Curr. Biol. 16:47-55(2006).
CC -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC kinases and is essential for their biological function (By similarity).
CC Has a role in the exit from M phase during early mitotic cell division.
CC More specifically, thought to act by degrading B-type cyclins that
CC causes breakdown of nuclear envelope and exit mitosis. {ECO:0000250,
CC ECO:0000269|PubMed:11102813, ECO:0000269|PubMed:16343905}.
CC -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase subunits
CC (By similarity). Interacts with cdk-1. {ECO:0000250,
CC ECO:0000269|PubMed:16343905}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit defects in the completion of
CC maternal meiosis, embryonic mitosis and arrest in embryogenesis.
CC {ECO:0000269|PubMed:11102813}.
CC -!- SIMILARITY: Belongs to the CKS family. {ECO:0000305}.
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DR EMBL; AF016224; AAC27123.1; -; Genomic_DNA.
DR EMBL; FO080478; CCD63999.1; -; Genomic_DNA.
DR PIR; T29829; T29829.
DR RefSeq; NP_501457.1; NM_069056.6.
DR AlphaFoldDB; Q17868; -.
DR SMR; Q17868; -.
DR BioGRID; 42770; 18.
DR DIP; DIP-25964N; -.
DR IntAct; Q17868; 6.
DR STRING; 6239.C09G4.3; -.
DR EPD; Q17868; -.
DR PaxDb; Q17868; -.
DR PeptideAtlas; Q17868; -.
DR EnsemblMetazoa; C09G4.3.1; C09G4.3.1; WBGene00001051.
DR UCSC; C09G4.3; c. elegans.
DR WormBase; C09G4.3; CE03980; WBGene00001051; cks-1.
DR eggNOG; KOG3484; Eukaryota.
DR GeneTree; ENSGT00950000182971; -.
DR HOGENOM; CLU_140546_1_2_1; -.
DR InParanoid; Q17868; -.
DR OMA; WMSESEW; -.
DR OrthoDB; 1377855at2759; -.
DR PhylomeDB; Q17868; -.
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-69231; Cyclin D associated events in G1.
DR SignaLink; Q17868; -.
DR PRO; PR:Q17868; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001051; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0009794; P:regulation of mitotic cell cycle, embryonic; IMP:UniProtKB.
DR Gene3D; 3.30.170.10; -; 1.
DR InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR Pfam; PF01111; CKS; 1.
DR PRINTS; PR00296; CYCLINKINASE.
DR SMART; SM01084; CKS; 1.
DR SUPFAM; SSF55637; SSF55637; 1.
DR PROSITE; PS00944; CKS_1; 1.
DR PROSITE; PS00945; CKS_2; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..94
FT /note="Cyclin-dependent kinases regulatory subunit"
FT /id="PRO_0000206244"
FT MUTAGEN 10
FT /note="Y->F: In ne549; reduces cdk-1 binding."
FT /evidence="ECO:0000269|PubMed:16343905"
SQ SEQUENCE 94 AA; 10952 MW; 2238BF6F85955151 CRC64;
MTTGNNDFYY SNKYEDDEFE YRHVHVTKDV SKLIPKNRLM SETEWRSLGI QQSPGWMHYM
IHGPERHVLL FRRPLAATQK TGGNVRSGNA VGVR
