ID   CKS1_LEIME              Reviewed;          99 AA.
AC   Q25330;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Cyclin-dependent kinases regulatory subunit;
DE   AltName: Full=P12LMMCKS1;
OS   Leishmania mexicana.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MNYC/BZ/62/M379;
RX   PubMed=8670159; DOI=10.1042/bj3160833;
RA   Mottram J.C., Grant K.M.;
RT   "Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1,
RT   associates with a stage-regulated histone H1 kinase.";
RL   Biochem. J. 316:833-839(1996).
CC   -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC       kinases (Cdc2) and is essential for their biological function.
CC   -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CKS family. {ECO:0000305}.
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DR   EMBL; Z49881; CAA90037.1; -; Genomic_DNA.
DR   PIR; S70645; S70645.
DR   AlphaFoldDB; Q25330; -.
DR   SMR; Q25330; -.
DR   VEuPathDB; TriTrypDB:LmxM.31.3790; -.
DR   OMA; RPINYGQ; -.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.170.10; -; 1.
DR   InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR   InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR   Pfam; PF01111; CKS; 1.
DR   PRINTS; PR00296; CYCLINKINASE.
DR   SMART; SM01084; CKS; 1.
DR   SUPFAM; SSF55637; SSF55637; 1.
DR   PROSITE; PS00944; CKS_1; 1.
DR   PROSITE; PS00945; CKS_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division.
FT   CHAIN           1..99
FT                   /note="Cyclin-dependent kinases regulatory subunit"
FT                   /id="PRO_0000206243"
SQ   SEQUENCE   99 AA;  11832 MW;  5F2C766A69AD5222 CRC64;
     MPAKPAQDFF SLDANGQREA LIIIKKLQCK ILYSDKYYDD MFEYRHVILP KDLARLVPTS
     RLMSEMEWRQ LGVQQSQGWV HYMIHKPEPH VLLFKRPRT