ID   CKS2_ARATH              Reviewed;          83 AA.
AC   Q9SJJ5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Cyclin-dependent kinases regulatory subunit 2;
GN   Name=CKS2; OrderedLocusNames=At2g27970; ORFNames=T1E2.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11971144; DOI=10.1105/tpc.010445;
RA   Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.;
RT   "Genome-wide analysis of core cell cycle genes in Arabidopsis.";
RL   Plant Cell 14:903-916(2002).
RN   [5]
RP   INTERACTION WITH CDKA-1; CYCD2-1 AND AT4G14310.
RX   PubMed=20706207; DOI=10.1038/msb.2010.53;
RA   Van Leene J., Hollunder J., Eeckhout D., Persiau G., Van De Slijke E.,
RA   Stals H., Van Isterdael G., Verkest A., Neirynck S., Buffel Y., De Bodt S.,
RA   Maere S., Laukens K., Pharazyn A., Ferreira P.C.G., Eloy N., Renne C.,
RA   Meyer C., Faure J.-D., Steinbrenner J., Beynon J., Larkin J.C.,
RA   Van de Peer Y., Hilson P., Kuiper M., De Veylder L., Van Onckelen H.,
RA   Inze D., Witters E., De Jaeger G.;
RT   "Targeted interactomics reveals a complex core cell cycle machinery in
RT   Arabidopsis thaliana.";
RL   Mol. Syst. Biol. 6:397-397(2010).
CC   -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC       kinases and is essential for their biological function. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CDKA-1, CYCD2-1 and AT4G14310.
CC       {ECO:0000269|PubMed:20706207}.
CC   -!- SIMILARITY: Belongs to the CKS family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC006929; AAD21505.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08065.1; -; Genomic_DNA.
DR   EMBL; BT010784; AAR24151.1; -; mRNA.
DR   EMBL; BT011257; AAR92293.1; -; mRNA.
DR   PIR; B84679; B84679.
DR   RefSeq; NP_180364.1; NM_128356.6.
DR   AlphaFoldDB; Q9SJJ5; -.
DR   SMR; Q9SJJ5; -.
DR   BioGRID; 2691; 50.
DR   IntAct; Q9SJJ5; 35.
DR   STRING; 3702.AT2G27970.1; -.
DR   PaxDb; Q9SJJ5; -.
DR   PRIDE; Q9SJJ5; -.
DR   ProteomicsDB; 222091; -.
DR   EnsemblPlants; AT2G27970.1; AT2G27970.1; AT2G27970.
DR   GeneID; 817341; -.
DR   Gramene; AT2G27970.1; AT2G27970.1; AT2G27970.
DR   KEGG; ath:AT2G27970; -.
DR   Araport; AT2G27970; -.
DR   TAIR; locus:2057825; AT2G27970.
DR   eggNOG; KOG3484; Eukaryota.
DR   HOGENOM; CLU_140546_2_0_1; -.
DR   InParanoid; Q9SJJ5; -.
DR   OMA; NPEPHVL; -.
DR   OrthoDB; 1377855at2759; -.
DR   PhylomeDB; Q9SJJ5; -.
DR   PRO; PR:Q9SJJ5; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SJJ5; baseline and differential.
DR   Genevisible; Q9SJJ5; AT.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   Gene3D; 3.30.170.10; -; 1.
DR   InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR   InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR   Pfam; PF01111; CKS; 1.
DR   PRINTS; PR00296; CYCLINKINASE.
DR   SMART; SM01084; CKS; 1.
DR   SUPFAM; SSF55637; SSF55637; 1.
DR   PROSITE; PS00944; CKS_1; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..83
FT                   /note="Cyclin-dependent kinases regulatory subunit 2"
FT                   /id="PRO_0000294095"
SQ   SEQUENCE   83 AA;  9987 MW;  23BCACF0DEF10C03 CRC64;
     MGQIQYSDKY FDDTFEYRHV VLPPEVAKLL PKNRILSESE WRAIGVQQSR GWVHYAIHRP
     EPHIMLFRRP LNYQQEHQAQ IAK