ID   CL004_MOUSE             Reviewed;         552 AA.
AC   Q91YN0; Q3UVK4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein C12orf4 homolog;
GN   Name=D6Wsu163e;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RC   TISSUE=Adipose tissue, Corpora quadrigemina, and Urinary bladder;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Plays a role in mast cell degranulation.
CC       {ECO:0000250|UniProtKB:D4A770}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:D4A770}.
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DR   EMBL; AK045541; BAC32412.1; -; mRNA.
DR   EMBL; AK046707; BAC32841.1; -; mRNA.
DR   EMBL; AK137201; BAE23265.1; -; mRNA.
DR   EMBL; BC016429; AAH16429.1; -; mRNA.
DR   CCDS; CCDS20560.1; -.
DR   RefSeq; NP_613060.1; NM_138594.3.
DR   RefSeq; XP_006506280.1; XM_006506217.1.
DR   AlphaFoldDB; Q91YN0; -.
DR   BioGRID; 205730; 1.
DR   STRING; 10090.ENSMUSP00000032497; -.
DR   iPTMnet; Q91YN0; -.
DR   PhosphoSitePlus; Q91YN0; -.
DR   EPD; Q91YN0; -.
DR   MaxQB; Q91YN0; -.
DR   PaxDb; Q91YN0; -.
DR   PeptideAtlas; Q91YN0; -.
DR   PRIDE; Q91YN0; -.
DR   ProteomicsDB; 279094; -.
DR   Antibodypedia; 41818; 82 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000032497; ENSMUSP00000032497; ENSMUSG00000030347.
DR   GeneID; 28040; -.
DR   KEGG; mmu:28040; -.
DR   UCSC; uc009dvm.1; mouse.
DR   CTD; 28040; -.
DR   MGI; MGI:107893; D6Wsu163e.
DR   VEuPathDB; HostDB:ENSMUSG00000030347; -.
DR   eggNOG; KOG4506; Eukaryota.
DR   GeneTree; ENSGT00390000010229; -.
DR   HOGENOM; CLU_036084_0_0_1; -.
DR   InParanoid; Q91YN0; -.
DR   OMA; EMASWGG; -.
DR   OrthoDB; 743423at2759; -.
DR   PhylomeDB; Q91YN0; -.
DR   TreeFam; TF314243; -.
DR   BioGRID-ORCS; 28040; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; D6Wsu163e; mouse.
DR   PRO; PR:Q91YN0; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q91YN0; protein.
DR   Bgee; ENSMUSG00000030347; Expressed in saccule of membranous labyrinth and 242 other tissues.
DR   ExpressionAtlas; Q91YN0; baseline and differential.
DR   Genevisible; Q91YN0; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.
DR   InterPro; IPR019311; DUF2362.
DR   PANTHER; PTHR16525; PTHR16525; 1.
DR   Pfam; PF10154; DUF2362; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..552
FT                   /note="Protein C12orf4 homolog"
FT                   /id="PRO_0000089843"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   552 AA;  63644 MW;  79C9C39ECBA14BCE CRC64;
     MKKNRERFCN KEREFVYKFQ VGRERLELRV PLRFPVEENA SHLHGRLMLL HSLPCFIESD
     LKDALSRFIE EESLRDHDSD AEACLEAVKS GEVDLHQLAS AWAKAYAETT LEHARPEEPD
     WDEDFADVYH DLIHSPASET LLNLEHNYFV SISELIGERD VELKKLRERQ GIEMEKVMQE
     LGKSLTDQDV NSLAAQHFES QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS
     SLSEEIKVQP SQFRESADAA GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
     HKRTHGSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC QECTDFHFPR
     IEEQLEVVQQ VALYARTQRK SKCKEARDSG NQNGGSDDKS KNAERNYLNI LPGEFYITRH
     SNLSEIHVAF HLCVDDNVKS GNITARDPAI MGLRNILKVC CTHDITTISI PLLLVHDMSE
     EMTIPWCLRR AELVFKCVKG FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF
     RVSSTLTLTS KH