CL004_RAT
ID CL004_RAT Reviewed; 552 AA.
AC D4A770;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Protein C12orf4 homolog;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, AND FUNCTION.
RX PubMed=25122211; DOI=10.1371/journal.pone.0104998;
RA Mazuc E., Guglielmi L., Bec N., Parez V., Hahn C.S., Mollevi C.,
RA Parrinello H., Desvignes J.P., Larroque C., Jupp R., Dariavach P.,
RA Martineau P.;
RT "In-cell intrabody selection from a diverse human library identifies
RT C12orf4 protein as a new player in rodent mast cell degranulation.";
RL PLoS ONE 9:E104998-E104998(2014).
CC -!- FUNCTION: Plays a role in mast cell degranulation.
CC {ECO:0000269|PubMed:25122211}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25122211}.
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DR EMBL; AABR06033849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR06033850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR06033851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473964; EDM01821.1; -; Genomic_DNA.
DR RefSeq; NP_001100093.1; NM_001106623.1.
DR AlphaFoldDB; D4A770; -.
DR STRING; 10116.ENSRNOP00000026838; -.
DR PaxDb; D4A770; -.
DR PeptideAtlas; D4A770; -.
DR Ensembl; ENSRNOT00000089513; ENSRNOP00000074196; ENSRNOG00000055036.
DR GeneID; 297607; -.
DR KEGG; rno:297607; -.
DR UCSC; RGD:1311164; rat.
DR CTD; 297607; -.
DR RGD; 1311164; RGD1311164.
DR eggNOG; KOG4506; Eukaryota.
DR GeneTree; ENSGT00390000010229; -.
DR HOGENOM; CLU_036084_0_0_1; -.
DR InParanoid; D4A770; -.
DR OMA; EMASWGG; -.
DR OrthoDB; 743423at2759; -.
DR PhylomeDB; D4A770; -.
DR TreeFam; TF314243; -.
DR PRO; PR:D4A770; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Proteomes; UP000234681; Chromosome 4.
DR Bgee; ENSRNOG00000055036; Expressed in cerebellum and 19 other tissues.
DR Genevisible; D4A770; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0043304; P:regulation of mast cell degranulation; IDA:UniProtKB.
DR InterPro; IPR019311; DUF2362.
DR PANTHER; PTHR16525; PTHR16525; 1.
DR Pfam; PF10154; DUF2362; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..552
FT /note="Protein C12orf4 homolog"
FT /id="PRO_0000431922"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91YN0"
SQ SEQUENCE 552 AA; 63619 MW; 1E928892A77E3A85 CRC64;
MKKNRERFSS KEREFVYKFQ IGSERLELRV PLRFPVDENA SHLHGRLMLL HSLPCFIEND
LKEALARFIE EESLRDHDSD AEACLEAVKS GEVDLHQLAS TWAKAYAETT LEHARPEEPN
WDEDFADVYH DLIHSPASET LLNLEHNYFV SISELIGERD VELKKLRERQ GIEMEKVMQE
LGKSLTDQDV NSLAAQHFES QQDLENKWSN ELKQSTAIQK QEYQEWVIKL HQDLKNPNNS
SLSEEIKVQP SQFRESADAA GRIYEEQRKL EESFTIHLGA QLKTMHNLRL LRADMLDFCK
HKRTQGSGVK LHRLQTALSL YSTSLCGLVL LVDNRINSYS GIKRDFATVC QECTDFHFPR
IEEQLEVVQQ VALYARTQRR SKCKEARDSG NQNGGSDEKS KNAERNYLNI LPGEFYITRH
SNLSEIHVAF HLCVDDNVKS GNITARDPAI MGLRNILKVC CTHDITTISI PLLLVHDMSE
EMTIPWCLRR AELVFKCVKG FMMEMASWDG GISRTVQFLV PQSISEEMFY QLSNMLPQIF
RVSSTLTLTS KH
