CL050_HUMAN
ID CL050_HUMAN Reviewed; 414 AA.
AC Q8NA57; Q6P674;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized protein C12orf50;
GN Name=C12orf50;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NA57; Q08379: GOLGA2; NbExp=7; IntAct=EBI-10268935, EBI-618309;
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DR EMBL; AK093140; BAC04071.1; -; mRNA.
DR EMBL; BC038413; AAH38413.1; -; mRNA.
DR EMBL; BC062424; AAH62424.1; ALT_SEQ; mRNA.
DR CCDS; CCDS9031.1; -.
DR RefSeq; NP_689802.1; NM_152589.1.
DR AlphaFoldDB; Q8NA57; -.
DR BioGRID; 127758; 5.
DR IntAct; Q8NA57; 2.
DR STRING; 9606.ENSP00000298699; -.
DR iPTMnet; Q8NA57; -.
DR PhosphoSitePlus; Q8NA57; -.
DR BioMuta; C12orf50; -.
DR PaxDb; Q8NA57; -.
DR PeptideAtlas; Q8NA57; -.
DR PRIDE; Q8NA57; -.
DR ProteomicsDB; 72642; -.
DR Antibodypedia; 44593; 89 antibodies from 15 providers.
DR DNASU; 160419; -.
DR Ensembl; ENST00000298699.7; ENSP00000298699.2; ENSG00000165805.10.
DR GeneID; 160419; -.
DR KEGG; hsa:160419; -.
DR MANE-Select; ENST00000298699.7; ENSP00000298699.2; NM_152589.3; NP_689802.1.
DR UCSC; uc001tam.2; human.
DR CTD; 160419; -.
DR DisGeNET; 160419; -.
DR GeneCards; C12orf50; -.
DR HGNC; HGNC:26665; C12orf50.
DR HPA; ENSG00000165805; Tissue enriched (testis).
DR neXtProt; NX_Q8NA57; -.
DR OpenTargets; ENSG00000165805; -.
DR PharmGKB; PA143485379; -.
DR VEuPathDB; HostDB:ENSG00000165805; -.
DR eggNOG; KOG4791; Eukaryota.
DR GeneTree; ENSGT00920000149095; -.
DR HOGENOM; CLU_653083_0_0_1; -.
DR InParanoid; Q8NA57; -.
DR OMA; MCYKSGR; -.
DR OrthoDB; 623337at2759; -.
DR PhylomeDB; Q8NA57; -.
DR TreeFam; TF335608; -.
DR PathwayCommons; Q8NA57; -.
DR SignaLink; Q8NA57; -.
DR BioGRID-ORCS; 160419; 9 hits in 1035 CRISPR screens.
DR GenomeRNAi; 160419; -.
DR Pharos; Q8NA57; Tdark.
DR PRO; PR:Q8NA57; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NA57; protein.
DR Bgee; ENSG00000165805; Expressed in sperm and 83 other tissues.
DR ExpressionAtlas; Q8NA57; baseline and differential.
DR Genevisible; Q8NA57; HS.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR040943; DUF5571.
DR InterPro; IPR041686; Znf-CCCH_3.
DR Pfam; PF17732; DUF5571; 1.
DR Pfam; PF15663; zf-CCCH_3; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..414
FT /note="Uncharacterized protein C12orf50"
FT /id="PRO_0000295234"
FT REGION 136..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 306
FT /note="Q -> R (in dbSNP:rs10777084)"
FT /id="VAR_033266"
FT VARIANT 322
FT /note="R -> H (in dbSNP:rs11104703)"
FT /id="VAR_033267"
SQ SEQUENCE 414 AA; 47326 MW; B8DA1067481EAB8D CRC64;
MEMQQNCSIS CFWETQPLGC VKISCIFYHS KPRNINGLFL PPSSNITLQK EIQEGIPLQS
QSQEPLKPQE NISRPIHHPL VLKTNFEEEE EVDEQNDASS LWTKTPEEIE EKRAIKEMCY
KSGEYYRFHT PPDILSSKSM TPTAEKQLEK PLENGSELQE GDSLTVPTKL SQYERQGEIK
TSLHGKPKTD IAAFENGGGD CYVPQRVIFL GVDESEALTE EKEITISKCS NTKDNKDSPH
PKHSLTTRLV PTTHVLNATE NISMKCREDP SSMNDVQPVK KPHFKGVKKR KWIYDEPQNF
PNSGMQRAVQ APRPQNKMSY HRNNKNRNAE NASYIHVQRD AVRTVALNAP SRSRPTHGSY
NKVHANREPK PNLSPDKYTS TSYNDSAWRK RIPFSKTYSK SEKIYPEPRR NGSK
