ID   CL056_HUMAN             Reviewed;         622 AA.
AC   Q8IXR9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Uncharacterized protein C12orf56;
GN   Name=C12orf56;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-622 (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8IXR9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IXR9-2; Sequence=VSP_031745;
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DR   EMBL; AC012158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC135279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC039369; AAH39369.1; -; mRNA.
DR   CCDS; CCDS44935.1; -. [Q8IXR9-2]
DR   CCDS; CCDS61182.1; -. [Q8IXR9-1]
DR   RefSeq; NP_001093146.1; NM_001099676.2. [Q8IXR9-2]
DR   RefSeq; NP_001164104.1; NM_001170633.1. [Q8IXR9-1]
DR   AlphaFoldDB; Q8IXR9; -.
DR   BioGRID; 125452; 1.
DR   STRING; 9606.ENSP00000446101; -.
DR   iPTMnet; Q8IXR9; -.
DR   PhosphoSitePlus; Q8IXR9; -.
DR   BioMuta; C12orf56; -.
DR   DMDM; 449081294; -.
DR   MaxQB; Q8IXR9; -.
DR   PaxDb; Q8IXR9; -.
DR   PeptideAtlas; Q8IXR9; -.
DR   PRIDE; Q8IXR9; -.
DR   Antibodypedia; 66385; 26 antibodies from 8 providers.
DR   DNASU; 115749; -.
DR   Ensembl; ENST00000333722.9; ENSP00000329698.5; ENSG00000185306.13. [Q8IXR9-2]
DR   Ensembl; ENST00000543942.7; ENSP00000446101.2; ENSG00000185306.13. [Q8IXR9-1]
DR   GeneID; 115749; -.
DR   KEGG; hsa:115749; -.
DR   MANE-Select; ENST00000543942.7; ENSP00000446101.2; NM_001170633.2; NP_001164104.1.
DR   UCSC; uc001ssa.5; human. [Q8IXR9-1]
DR   CTD; 115749; -.
DR   GeneCards; C12orf56; -.
DR   HGNC; HGNC:26967; C12orf56.
DR   HPA; ENSG00000185306; Tissue enhanced (choroid plexus, testis).
DR   neXtProt; NX_Q8IXR9; -.
DR   OpenTargets; ENSG00000185306; -.
DR   PharmGKB; PA143485385; -.
DR   VEuPathDB; HostDB:ENSG00000185306; -.
DR   eggNOG; ENOG502QVPD; Eukaryota.
DR   GeneTree; ENSGT00390000018424; -.
DR   HOGENOM; CLU_032455_1_0_1; -.
DR   InParanoid; Q8IXR9; -.
DR   OMA; LFWRSSE; -.
DR   OrthoDB; 530977at2759; -.
DR   PhylomeDB; Q8IXR9; -.
DR   TreeFam; TF331535; -.
DR   PathwayCommons; Q8IXR9; -.
DR   SignaLink; Q8IXR9; -.
DR   BioGRID-ORCS; 115749; 40 hits in 1039 CRISPR screens.
DR   ChiTaRS; C12orf56; human.
DR   GenomeRNAi; 115749; -.
DR   Pharos; Q8IXR9; Tdark.
DR   PRO; PR:Q8IXR9; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8IXR9; protein.
DR   Bgee; ENSG00000185306; Expressed in sperm and 109 other tissues.
DR   ExpressionAtlas; Q8IXR9; baseline and differential.
DR   Genevisible; Q8IXR9; HS.
DR   InterPro; IPR027878; DUF4551.
DR   PANTHER; PTHR35354; PTHR35354; 1.
DR   Pfam; PF15087; DUF4551; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..622
FT                   /note="Uncharacterized protein C12orf56"
FT                   /id="PRO_0000320926"
FT   REGION          157..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         164..323
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031745"
SQ   SEQUENCE   622 AA;  71046 MW;  35E0DC70E2A6A354 CRC64;
     MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL KYVVLSDRLV
     YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS QHIRIIYSST VLKKECKKSN
     SVRKFLFPFH HTKANNKKVK EEKNGLAFWR SKESRSLKES PLRDQQESST PSKDSTLCPR
     PGLKKLSLHG QGAFRPLPSP SRRSSQSAPT TGKAVSEPSC TTNTKEPQGL PDHNSISEIP
     FKCNGNGNEF YLGNSLLDSP SQSNSNLEKK ESELHLYVIS TTSSIFLHLK SSWNNYIIKA
     TLLQDPFYAS EFSPAIGSQK PYRSEEKIKH FSQLKSELFL KDNSLRRILS LLMELKVAAQ
     KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS QRVDELVACI EIIQTLVLMF
     RETETESSRL NTLAAKKGAL FNLLVILISE PQIPKSCPVF DIQLVADSAL VRMSFDAELQ
     KLILEYTNTA TALLYEILLV FQQGNLGLGS TKFAISWIMS FLQSCPPIIT FVASIVKQVV
     RGLSASFQLL SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR NNYREEFRYF IHMPALQKRL
     PLCYPITQPT IQLFHEVLKL VE