CL060_HUMAN
ID CL060_HUMAN Reviewed; 245 AA.
AC Q5U649; A8K1M7; Q5XKK8; Q8IXY2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Uncharacterized protein C12orf60;
GN Name=C12orf60;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-51.
RC TISSUE=Brain, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5U649; Q96DN0: ERP27; NbExp=3; IntAct=EBI-10488839, EBI-953772;
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DR EMBL; AK289942; BAF82631.1; -; mRNA.
DR EMBL; BC015546; AAH15546.1; -; mRNA.
DR EMBL; BC029443; AAH29443.1; -; mRNA.
DR EMBL; BC038836; AAH38836.1; -; mRNA.
DR CCDS; CCDS8667.1; -.
DR RefSeq; NP_787070.2; NM_175874.3.
DR RefSeq; XP_005253379.1; XM_005253322.4.
DR RefSeq; XP_011518870.1; XM_011520568.2.
DR RefSeq; XP_011518871.1; XM_011520569.2.
DR RefSeq; XP_016874360.1; XM_017018871.1.
DR RefSeq; XP_016874361.1; XM_017018872.1.
DR RefSeq; XP_016874362.1; XM_017018873.1.
DR RefSeq; XP_016874363.1; XM_017018874.1.
DR AlphaFoldDB; Q5U649; -.
DR BioGRID; 126866; 38.
DR IntAct; Q5U649; 2.
DR STRING; 9606.ENSP00000331691; -.
DR GlyGen; Q5U649; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5U649; -.
DR PhosphoSitePlus; Q5U649; -.
DR BioMuta; C12orf60; -.
DR DMDM; 125863778; -.
DR EPD; Q5U649; -.
DR MassIVE; Q5U649; -.
DR PaxDb; Q5U649; -.
DR PeptideAtlas; Q5U649; -.
DR PRIDE; Q5U649; -.
DR ProteomicsDB; 65239; -.
DR Antibodypedia; 51929; 39 antibodies from 11 providers.
DR DNASU; 144608; -.
DR Ensembl; ENST00000330828.3; ENSP00000331691.2; ENSG00000182993.5.
DR GeneID; 144608; -.
DR KEGG; hsa:144608; -.
DR MANE-Select; ENST00000330828.3; ENSP00000331691.2; NM_175874.4; NP_787070.2.
DR UCSC; uc001rcj.5; human.
DR CTD; 144608; -.
DR DisGeNET; 144608; -.
DR GeneCards; C12orf60; -.
DR HGNC; HGNC:28726; C12orf60.
DR HPA; ENSG00000182993; Tissue enhanced (testis).
DR MalaCards; C12orf60; -.
DR neXtProt; NX_Q5U649; -.
DR OpenTargets; ENSG00000182993; -.
DR PharmGKB; PA143485389; -.
DR VEuPathDB; HostDB:ENSG00000182993; -.
DR eggNOG; ENOG502S734; Eukaryota.
DR GeneTree; ENSGT00390000003800; -.
DR HOGENOM; CLU_1124225_0_0_1; -.
DR InParanoid; Q5U649; -.
DR OMA; LMKFPIM; -.
DR OrthoDB; 1399012at2759; -.
DR PhylomeDB; Q5U649; -.
DR TreeFam; TF338464; -.
DR PathwayCommons; Q5U649; -.
DR SignaLink; Q5U649; -.
DR BioGRID-ORCS; 144608; 14 hits in 1025 CRISPR screens.
DR ChiTaRS; C12orf60; human.
DR GenomeRNAi; 144608; -.
DR Pharos; Q5U649; Tdark.
DR PRO; PR:Q5U649; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q5U649; protein.
DR Bgee; ENSG00000182993; Expressed in sperm and 131 other tissues.
DR Genevisible; Q5U649; HS.
DR InterPro; IPR027895; DUF4533.
DR Pfam; PF15047; DUF4533; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..245
FT /note="Uncharacterized protein C12orf60"
FT /id="PRO_0000274271"
FT REGION 162..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 51
FT /note="K -> R (in dbSNP:rs17853860)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030226"
FT VARIANT 65
FT /note="K -> R (in dbSNP:rs7304054)"
FT /id="VAR_030227"
FT VARIANT 103
FT /note="N -> K (in dbSNP:rs7307438)"
FT /id="VAR_030228"
FT CONFLICT 42
FT /note="N -> D (in Ref. 2; AAH29443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27626 MW; C424D710741D7FD5 CRC64;
MSSESEKDKE RLIQAAKMFF FHVQDLASVI NTLTELFSRS MNTQILLMAV KNNSYIKDFF
EQMLKIFKEM QSVVDARHDK IQKESLCSKV AMAMCSVVQK STNVEELHQS AKEVFKSAHT
PVIISVLNSS NILGSLESSL SHLMKFPIMN LQLSDFYTED TKEQSDVTTS ERTRSPPGSS
KTTMIDTLKK LQDVLKTEDS KNPTKSAADL LEQIVKAMGP ILEILQKAIK TMEMNISVFK
KASDK
