ID   CL076_HUMAN             Reviewed;         135 AA.
AC   Q8N812;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Uncharacterized protein C12orf76;
GN   Name=C12orf76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   VARIANT [LARGE SCALE ANALYSIS] THR-26.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
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DR   EMBL; AK097461; BAC05063.1; -; mRNA.
DR   EMBL; BC133010; AAI33011.1; -; mRNA.
DR   EMBL; BC133012; AAI33013.1; -; mRNA.
DR   RefSeq; NP_997318.1; NM_207435.2.
DR   AlphaFoldDB; Q8N812; -.
DR   BioGRID; 134509; 1.
DR   IntAct; Q8N812; 2.
DR   STRING; 9606.ENSP00000308368; -.
DR   BioMuta; C12orf76; -.
DR   PaxDb; Q8N812; -.
DR   PRIDE; Q8N812; -.
DR   DNASU; 400073; -.
DR   GeneID; 400073; -.
DR   UCSC; uc001tqd.2; human.
DR   CTD; 400073; -.
DR   DisGeNET; 400073; -.
DR   GeneCards; C12orf76; -.
DR   HGNC; HGNC:33790; C12orf76.
DR   neXtProt; NX_Q8N812; -.
DR   PharmGKB; PA165512406; -.
DR   eggNOG; ENOG502TECA; Eukaryota.
DR   HOGENOM; CLU_1885129_0_0_1; -.
DR   InParanoid; Q8N812; -.
DR   OrthoDB; 1399936at2759; -.
DR   PhylomeDB; Q8N812; -.
DR   TreeFam; TF342372; -.
DR   PathwayCommons; Q8N812; -.
DR   SignaLink; Q8N812; -.
DR   BioGRID-ORCS; 400073; 16 hits in 1050 CRISPR screens.
DR   ChiTaRS; C12orf76; human.
DR   GenomeRNAi; 400073; -.
DR   Pharos; Q8N812; Tdark.
DR   PRO; PR:Q8N812; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8N812; protein.
DR   Genevisible; Q8N812; HS.
DR   InterPro; IPR041240; DUF5541.
DR   Pfam; PF17695; DUF5541; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..135
FT                   /note="Uncharacterized protein C12orf76"
FT                   /id="PRO_0000325799"
FT   VARIANT         26
FT                   /note="A -> T (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_039916"
SQ   SEQUENCE   135 AA;  14959 MW;  42A798DE2376F0B3 CRC64;
     MFQNLQGTFE KEIGKIIPFT IAFKRAEAVE PDGCVQSWRC CLPCDLGQAS RFIHTTVCSA
     IRWRSCKGER NFAERHILPA ELEEQSNHAG MGPILPAMPS VDGNHFQHPA GDCHPYGILC
     LQAHSASVTA RQVLQ