ACHB3_RAT
ID ACHB3_RAT Reviewed; 464 AA.
AC P12391;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Neuronal acetylcholine receptor subunit beta-3;
DE Flags: Precursor;
GN Name=Chrnb3; Synonyms=Acrb3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2703489; DOI=10.1016/s0021-9258(18)83343-9;
RA Deneris E.S., Boulter J., Swanson L.W., Patrick J., Heinemann S.F.;
RT "Beta 3: a new member of nicotinic acetylcholine receptor gene family is
RT expressed in brain.";
RL J. Biol. Chem. 264:6268-6272(1989).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different types of
CC subunits: alpha and beta.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; J04636; AAC28887.1; -; mRNA.
DR PIR; A33523; A33523.
DR RefSeq; NP_598281.1; NM_133597.1.
DR AlphaFoldDB; P12391; -.
DR SMR; P12391; -.
DR ComplexPortal; CPX-203; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3.
DR STRING; 10116.ENSRNOP00000016656; -.
DR BindingDB; P12391; -.
DR ChEMBL; CHEMBL3137275; -.
DR ChEMBL; CHEMBL3883329; -.
DR DrugCentral; P12391; -.
DR GlyGen; P12391; 2 sites.
DR PhosphoSitePlus; P12391; -.
DR PaxDb; P12391; -.
DR Ensembl; ENSRNOT00000016656; ENSRNOP00000016656; ENSRNOG00000012448.
DR GeneID; 171131; -.
DR KEGG; rno:171131; -.
DR UCSC; RGD:621544; rat.
DR CTD; 1142; -.
DR RGD; 621544; Chrnb3.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000156892; -.
DR HOGENOM; CLU_018074_1_2_1; -.
DR InParanoid; P12391; -.
DR OMA; EWMDHKL; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; P12391; -.
DR TreeFam; TF315605; -.
DR Reactome; R-RNO-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR Reactome; R-RNO-629597; Highly calcium permeable nicotinic acetylcholine receptors.
DR PRO; PR:P12391; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000012448; Expressed in testis and 3 other tissues.
DR Genevisible; P12391; RN.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IDA:RGD.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098691; C:dopaminergic synapse; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IDA:RGD.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0042166; F:acetylcholine binding; IDA:RGD.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051899; P:membrane depolarization; IC:ComplexPortal.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:RGD.
DR GO; GO:0035094; P:response to nicotine; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..464
FT /note="Neuronal acetylcholine receptor subunit beta-3"
FT /id="PRO_0000000386"
FT TOPO_DOM 31..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..434
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 159..173
FT /evidence="ECO:0000250"
SQ SEQUENCE 464 AA; 53261 MW; 5D3B1F7DB934D1D8 CRC64;
MTGFLRVFLV LSATLSGSWV TLTATAGLSS VAEHEDALLR HLFQGYQKWV RPVLNSSDII
KVYFGLKISQ LVDVDEKNQL MTTNVWLKQE WTDQKLRWNP EEYGGINSIK VPSESLWLPD
IVLFENADGR FEGSLMTKAI VKSSGTVSWT PPASYKSSCT MDVTFFPFDR QNCSMKFGSW
TYDGTMVDLI LINENVDRKD FFDNGEWEIL NAKGMKGNRR EGFYSYPFVT YSFVLRRLPL
FYTLFLIIPC LGLSFLTVLV FYLPSDEGEK LSLSTSVLVS LTVFLLVIEE IIPSSSKVIP
LIGEYLLFIM IFVTLSIIVT VFVINVHHRS SSTYHPMAPW VKRLFLQRLP RWLCMKDPMD
RFSFPDGKES DTAVRGKVSG KRKQTPASDG ERVLVAFLEK ASESIRYISR HVKKEHFISQ
VVQDWKFVAQ VLDRIFLWLF LIASVLGSIL IFIPALKMWI HRFH
