CL162_CAEEL
ID CL162_CAEEL Reviewed; 313 AA.
AC P34312;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=C-type lectin domain-containing protein 162;
DE Flags: Precursor;
GN Name=clec-162; ORFNames=C07A9.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; Z29094; CAA82340.2; -; Genomic_DNA.
DR PIR; S40706; S40706.
DR RefSeq; NP_499148.2; NM_066747.4.
DR AlphaFoldDB; P34312; -.
DR SMR; P34312; -.
DR PaxDb; P34312; -.
DR EnsemblMetazoa; C07A9.1.1; C07A9.1.1; WBGene00007399.
DR GeneID; 182353; -.
DR KEGG; cel:CELE_C07A9.1; -.
DR UCSC; C07A9.1; c. elegans.
DR CTD; 182353; -.
DR WormBase; C07A9.1; CE37745; WBGene00007399; clec-162.
DR eggNOG; KOG4297; Eukaryota.
DR HOGENOM; CLU_1066470_0_0_1; -.
DR InParanoid; P34312; -.
DR OMA; EYWIGAS; -.
DR OrthoDB; 1156382at2759; -.
DR PhylomeDB; P34312; -.
DR Reactome; R-CEL-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-CEL-1482788; Acyl chain remodelling of PC.
DR Reactome; R-CEL-1482801; Acyl chain remodelling of PS.
DR Reactome; R-CEL-1482839; Acyl chain remodelling of PE.
DR Reactome; R-CEL-1482922; Acyl chain remodelling of PI.
DR Reactome; R-CEL-1482925; Acyl chain remodelling of PG.
DR Reactome; R-CEL-1483166; Synthesis of PA.
DR Reactome; R-CEL-6803157; Antimicrobial peptides.
DR PRO; PR:P34312; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007399; Expressed in adult organism.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Lectin; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..313
FT /note="C-type lectin domain-containing protein 162"
FT /id="PRO_0000017568"
FT DOMAIN 28..145
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 244..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..144
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 313 AA; 35131 MW; D6DC6721AB87DB80 CRC64;
MNIFTLLFIY FLSDTVAAYC YYGTEYKNAT GCFQFFRTPL NFTNAVRFCR VNMKSTLVRP
TSSIRNQQIR GAALKLGIEE YWIGASNVDN DWEWLDGSML TYSNFDVGGG YPKKTESQIG
AVSMSSLAGL WYTKLDAMFL PFVCEFPPST VYDNGILYRS PKTQSLIFPS AGTKAALLMV
DAVDQSRLYS KNEIGPLKTE AETGEKVYLK PINISTNGFP EFSGPPIVIL NPYKRKIKVK
PVMVSQTETE MSRSRKEKEE TEDSINVKSL KEGGTARGNG SSVAEELNSN SKEKREREEN
ETIRSKTIQI SRG
