CL16A_DICDI
ID CL16A_DICDI Reviewed; 1550 AA.
AC Q54GS1;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Protein CLEC16A homolog {ECO:0000305};
GN ORFNames=DDB_G0289943;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Regulator of mitophagy. {ECO:0000250|UniProtKB:Q80U30}.
CC -!- SIMILARITY: Belongs to the CLEC16A/gop-1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000149; EAL62484.1; -; Genomic_DNA.
DR RefSeq; XP_635998.1; XM_630906.1.
DR AlphaFoldDB; Q54GS1; -.
DR SMR; Q54GS1; -.
DR STRING; 44689.DDB0234043; -.
DR PaxDb; Q54GS1; -.
DR EnsemblProtists; EAL62484; EAL62484; DDB_G0289943.
DR GeneID; 8627413; -.
DR KEGG; ddi:DDB_G0289943; -.
DR dictyBase; DDB_G0289943; -.
DR eggNOG; KOG2219; Eukaryota.
DR HOGENOM; CLU_246423_0_0_1; -.
DR InParanoid; Q54GS1; -.
DR OMA; AEVMIWG; -.
DR PRO; PR:Q54GS1; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0036020; C:endolysosome membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0008333; P:endosome to lysosome transport; IBA:GO_Central.
DR GO; GO:1901096; P:regulation of autophagosome maturation; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039272; CLEC16A/TT9.
DR InterPro; IPR019155; CLEC16A/TT9_N.
DR InterPro; IPR045820; CLEC16A_C.
DR PANTHER; PTHR21481; PTHR21481; 2.
DR Pfam; PF19439; CLEC16A_C; 2.
DR Pfam; PF09758; FPL; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Autophagy; Reference proteome.
FT CHAIN 1..1550
FT /note="Protein CLEC16A homolog"
FT /id="PRO_0000356836"
FT DOMAIN 44..191
FT /note="FPL"
FT /evidence="ECO:0000255"
FT REGION 382..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..675
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1491..1513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1550 AA; 174529 MW; D6D5DFF547DC48E6 CRC64;
MNLLSQFMKP KNKFSIENLR YLHNTLKKNQ IITAQNKNLI VESLRQIAEV MIWGDQHDNL
FFDFFLEKNI MGFFIQFLAQ KTSTEVTIQL LQTLSILVEN LRNENSIYFL LSNNYINEII
IHKFDFSSEE VLDYFVSLLK ALSLKLDKST VNFFFNHVEK DFPLYTEAIK FVNHKETMIR
IAIRTLTLNI FKVENKEMRE YIINSTAVPY FSNIVWFIRR NCMSLSKVLE KSNHDSSYQL
KDYMDELTDQ FYYLHDIFNL GFESMNIVLA EQFIQYLIYP VFIGSLIDPL KNPDLEDRIT
PTLALYLLAH VFNIFSFKPL LDTISSALLT ATQSQAQLFT SATTAPPPLS TIASNRRHYN
SFRRFSSFPN LESLEAMKND GITSISDTDG RIGASGRLLN NTSTDEDSPP NSGFKPSNSV
QSTSSSPSTP KKYQQQFSRL FGSSRKPLPT TPSSSPKPST TSSITTSTTT TTPTTTITTT
TTTTTTTITP SSSPSKQNLS SSIESTNSLN NNNNNNNNNT TANNDNLEST QPKEDNLPTI
TVLNLNSPNE NSTKDDNNNN NNNNNNNNNN NNNNNNNTTP TPSTPTRKRF KFNRNEFKES
LLHLIGSDRE TFGIVIMLYS FLKNQHIDKR ILEKGGMLPY RLALLEGLLS PETNNNNSNN
NHHHHHHHHH HHSKTTVTSP NNQQQQQQVS HSTGGIKGQK NSKMSASLPI NIGHNRSRSE
SHAKSLLFNP NLYDTVTLEE RSLFKTPSPG SSSLFGELEI ETNKTDEGGD EKDEYDDGDD
ESSVNIRIKS SKHNSINSSV DSTIDLSKNN NNNNNNNNNN ENNNNDNNNE NNNVNNNNNI
NNNNNEESEE EEFVPVPESS QKDFTRRLIN ALFMVLVNSN QFRLVTLQMT LLILKELVYS
SDSSSKLTET QALLLEQAYI TVTDNLKECL SGPLSEVFLE IFEEELRSYK QIIFESLMED
VSLILPIPQK PVSRLSLSHR LPSGELERTQ KAVQQFLVLR ELKFTLLRKK DTMLPLKQPP
TPMVKEKYLF NLETGVVESS YDIIEYHHFE KVSGPTPPPP SGTPRKRFTH YGVLFHNLLL
AVDPPPSISS SSSSSASTSG SGTPNSSIGG TGGGGGGGMG SGTGGTSSPN PSNIIGGTNN
KGIYGTIVHI APLQRLEIET SHRDPSILRV TSHPTTWNVE MVFDDSTQCS KAKQMLERVR
DDVRATKMRQ IYALLGEKDP DDDSVPPQLN YGNMVERNPT NSDHDSNTTL NNEHNLLSSN
NNGEFSTSMS NTPPSRVITP IDTSNSHPLA NILGSDDNIS FVNNNNNNSN NNNTKKTTST
VNTPISTPHK LKKGNRGSSS NSSLNDSILP TLEDHLRKTV SPKVDMFNTS FFDDTLDLKE
LISTDELNNG NNNNNNEDNN ENPFSNIKRN SNEVKVGQPV QQEIEKEKEK ENIIGEDVEK
ETSIEQKEIK KDENDNNNIV EKEEEEIKDD NIKEEIKQDD SNNKEINNDN STTNNKEDEE
EEIKKDNKDE ENIVNIEHIN EKEVQEQQTE EQVEEIIKES VDIKVESDNN
