CL18A_MOUSE
ID CL18A_MOUSE Reviewed; 534 AA.
AC Q7TSQ1; Q7TMA7; Q7TSP9; Q7TSQ0; Q7TSQ7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=C-type lectin domain family 18 member A;
DE AltName: Full=Mannose receptor-like protein;
GN Name=Clec18a; Synonyms=Mrcl, Mrlp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RA Jang J.S. Sr., Ackerman S.L.;
RT "Alternatively spliced isoform 2 of mannose receptor precursor-like.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=Form 2;
CC IsoId=Q7TSQ1-1; Sequence=Displayed;
CC Name=2; Synonyms=Form 4;
CC IsoId=Q7TSQ1-2; Sequence=VSP_032209;
CC Name=3;
CC IsoId=Q7TSQ1-3; Sequence=VSP_032211;
CC Name=4; Synonyms=Form 6;
CC IsoId=Q7TSQ1-4; Sequence=VSP_032210;
CC Name=5; Synonyms=Form 3;
CC IsoId=Q7TSQ1-5; Sequence=VSP_032208;
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DR EMBL; AY223868; AAP20650.1; -; mRNA.
DR EMBL; AY223869; AAP22983.1; -; mRNA.
DR EMBL; AY223870; AAP22984.1; -; mRNA.
DR EMBL; AY223871; AAP22985.1; -; mRNA.
DR EMBL; AY223872; AAP22986.1; -; mRNA.
DR EMBL; AY223873; AAP22987.1; -; mRNA.
DR RefSeq; XP_006531206.3; XM_006531143.3. [Q7TSQ1-2]
DR AlphaFoldDB; Q7TSQ1; -.
DR SMR; Q7TSQ1; -.
DR STRING; 10090.ENSMUSP00000046546; -.
DR PhosphoSitePlus; Q7TSQ1; -.
DR PaxDb; Q7TSQ1; -.
DR PRIDE; Q7TSQ1; -.
DR DNASU; 353287; -.
DR Ensembl; ENSMUST00000039597; ENSMUSP00000046546; ENSMUSG00000033633. [Q7TSQ1-1]
DR Ensembl; ENSMUST00000188466; ENSMUSP00000141073; ENSMUSG00000033633. [Q7TSQ1-4]
DR Ensembl; ENSMUST00000191030; ENSMUSP00000139569; ENSMUSG00000033633. [Q7TSQ1-2]
DR Ensembl; ENSMUST00000191469; ENSMUSP00000139515; ENSMUSG00000033633. [Q7TSQ1-1]
DR GeneID; 353287; -.
DR UCSC; uc012gkt.1; mouse. [Q7TSQ1-4]
DR CTD; 348174; -.
DR MGI; MGI:2672935; Clec18a.
DR VEuPathDB; HostDB:ENSMUSG00000033633; -.
DR eggNOG; KOG3017; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00900000141128; -.
DR HOGENOM; CLU_039012_1_0_1; -.
DR InParanoid; Q7TSQ1; -.
DR OMA; TPQVGWN; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q7TSQ1; -.
DR TreeFam; TF350472; -.
DR BioGRID-ORCS; 353287; 1 hit in 21 CRISPR screens.
DR PRO; PR:Q7TSQ1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q7TSQ1; protein.
DR Bgee; ENSMUSG00000033633; Expressed in floor plate of midbrain and 45 other tissues.
DR ExpressionAtlas; Q7TSQ1; baseline and differential.
DR Genevisible; Q7TSQ1; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0030247; F:polysaccharide binding; ISO:MGI.
DR Gene3D; 3.10.100.10; -; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; EGF-like domain; Lectin; Receptor;
KW Reference proteome; Secreted.
FT CHAIN 1..534
FT /note="C-type lectin domain family 18 member A"
FT /id="PRO_0000324318"
FT DOMAIN 139..270
FT /note="SCP"
FT DOMAIN 316..349
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 394..521
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 47..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 324..337
FT /evidence="ECO:0000250"
FT DISULFID 339..348
FT /evidence="ECO:0000250"
FT DISULFID 415..520
FT /evidence="ECO:0000250"
FT DISULFID 496..512
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..155
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032208"
FT VAR_SEQ 1..128
FT /note="MTGAEEWKLSMGLEDTVPARLHEHGEASWTAERSHVCSIRQANDSAGALPVA
FT GKPEPMARSLASAPVSPWHHMDRGSTTPAKARSHSASYHCPSSSQICVPGVGSPSAGYG
FT DVPGASGHRPNLLSWPP -> MTGAEEWKLSMGLEDTVPARLSLTPRLVNSFMNTGRLA
FT GQLREAMSAASGRPMIQPEPSLWLGSQSRWLGLLLLLLSLLGITWTEVQPPQPKQDPTL
FT Q (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032209"
FT VAR_SEQ 1..128
FT /note="MTGAEEWKLSMGLEDTVPARLHEHGEASWTAERSHVCSIRQANDSAGALPVA
FT GKPEPMARSLASAPVSPWHHMDRGSTTPAKARSHSASYHCPSSSQICVPGVGSPSAGYG
FT DVPGASGHRPNLLSWPP -> MNTGRLAGQLREAMSAASGRPMIQPEPSLWLGSQSRWL
FT GLLLLLLSLLGITWTEVQPPQPKQDPTLQ (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032210"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032211"
SQ SEQUENCE 534 AA; 58585 MW; 9B0AF013370793FF CRC64;
MTGAEEWKLS MGLEDTVPAR LHEHGEASWT AERSHVCSIR QANDSAGALP VAGKPEPMAR
SLASAPVSPW HHMDRGSTTP AKARSHSASY HCPSSSQICV PGVGSPSAGY GDVPGASGHR
PNLLSWPPAL SRKESFLILT AHNRLRSRVH PPAANMQRMD WSESLAQLAE ARAALCVTSV
TPNLASTPGH NSHVGWNVQL MPMGSASFVE VVNLWFAEGL QYRHGDAECA HNATCAHYTQ
LVWATSSQLG CGRQPCFVDQ EAMEAFVCAY SPGGNWDING KTVAPYKKGT WCSLCTARVS
GCFKAWDHAG GLCEVPRNPC RMSCRNLGHL NISTCRCHCQ PGYTGRYCQV RCSVQCVHGQ
FRKEECSCIC DVGYGGAQCA TKVGFPFHTC DLRIDGDCFM VSPEADTYYG AKMKCQGKGG
VLAQIESQKV QDILAFYLGR LETTNEVTDS DFETKNFWIG LTYKAAKDSF RWTTGEHQSF
TSFAFGQPDN QGFGNCVEMQ ASAAFNWNDQ RCKTRNRYIC QFAQKHYSRW EPGP
