CL18B_HUMAN
ID CL18B_HUMAN Reviewed; 455 AA.
AC Q6UXF7; B4DF90;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=C-type lectin domain family 18 member B;
DE AltName: Full=Mannose receptor-like protein 1;
DE Flags: Precursor;
GN Name=CLEC18B; Synonyms=MRLP1; ORFNames=UNQ306/PRO347;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=26170455; DOI=10.1074/jbc.m115.649814;
RA Huang Y.L., Pai F.S., Tsou Y.T., Mon H.C., Hsu T.L., Wu C.Y., Chou T.Y.,
RA Yang W.B., Chen C.H., Wong C.H., Hsieh S.L.;
RT "Human CLEC18 gene cluster contains C-type lectins with differential
RT glycan-binding specificity.";
RL J. Biol. Chem. 290:21252-21263(2015).
CC -!- FUNCTION: Binds polysaccharides in a Ca(2+)-independent manner (By
CC similarity). {ECO:0000250|UniProtKB:A5D8T8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5D8T8}.
CC Endoplasmic reticulum {ECO:0000305|PubMed:26170455}. Golgi apparatus
CC {ECO:0000305|PubMed:26170455}. Endosome {ECO:0000305|PubMed:26170455}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UXF7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UXF7-2; Sequence=VSP_037307, VSP_037308, VSP_037309;
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DR EMBL; AY358373; AAQ88739.1; -; mRNA.
DR EMBL; AK293982; BAG57351.1; -; mRNA.
DR EMBL; AC009053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS32484.1; -. [Q6UXF7-1]
DR RefSeq; NP_001011880.2; NM_001011880.2. [Q6UXF7-1]
DR AlphaFoldDB; Q6UXF7; -.
DR SMR; Q6UXF7; -.
DR STRING; 9606.ENSP00000341051; -.
DR GlyGen; Q6UXF7; 1 site.
DR BioMuta; CLEC18B; -.
DR DMDM; 338817862; -.
DR MassIVE; Q6UXF7; -.
DR PaxDb; Q6UXF7; -.
DR PeptideAtlas; Q6UXF7; -.
DR PRIDE; Q6UXF7; -.
DR TopDownProteomics; Q6UXF7-2; -. [Q6UXF7-2]
DR Antibodypedia; 73352; 9 antibodies from 6 providers.
DR DNASU; 497190; -.
DR Ensembl; ENST00000339953.9; ENSP00000341051.5; ENSG00000140839.13. [Q6UXF7-1]
DR GeneID; 497190; -.
DR KEGG; hsa:497190; -.
DR UCSC; uc002fct.4; human. [Q6UXF7-1]
DR CTD; 497190; -.
DR DisGeNET; 497190; -.
DR GeneCards; CLEC18B; -.
DR HGNC; HGNC:33849; CLEC18B.
DR HPA; ENSG00000140839; Tissue enhanced (kidney, testis).
DR MIM; 616572; gene.
DR neXtProt; NX_Q6UXF7; -.
DR OpenTargets; ENSG00000140839; -.
DR PharmGKB; PA164718007; -.
DR VEuPathDB; HostDB:ENSG00000140839; -.
DR eggNOG; KOG3017; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00900000141128; -.
DR HOGENOM; CLU_039012_0_0_1; -.
DR InParanoid; Q6UXF7; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q6UXF7; -.
DR TreeFam; TF350472; -.
DR PathwayCommons; Q6UXF7; -.
DR BioGRID-ORCS; 497190; 37 hits in 996 CRISPR screens.
DR GenomeRNAi; 497190; -.
DR Pharos; Q6UXF7; Tdark.
DR PRO; PR:Q6UXF7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UXF7; protein.
DR Bgee; ENSG00000140839; Expressed in adult mammalian kidney and 91 other tissues.
DR ExpressionAtlas; Q6UXF7; baseline and differential.
DR Genevisible; Q6UXF7; HS.
DR GO; GO:0005768; C:endosome; TAS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; TAS:UniProtKB.
DR GO; GO:0016529; C:sarcoplasmic reticulum; TAS:UniProtKB.
DR GO; GO:0030247; F:polysaccharide binding; IBA:GO_Central.
DR Gene3D; 3.10.100.10; -; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; EGF-like domain;
KW Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Lectin;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..455
FT /note="C-type lectin domain family 18 member B"
FT /id="PRO_0000324315"
FT DOMAIN 52..182
FT /note="SCP"
FT DOMAIN 228..261
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 306..442
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 236..249
FT /evidence="ECO:0000250"
FT DISULFID 251..260
FT /evidence="ECO:0000250"
FT DISULFID 327..441
FT /evidence="ECO:0000250"
FT DISULFID 417..433
FT /evidence="ECO:0000250"
FT VAR_SEQ 73..152
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037307"
FT VAR_SEQ 261
FT /note="Q -> QGHLPNSNMPHSAMGTKPKTPGVPAIGSL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037308"
FT VAR_SEQ 293..455
FT /note="TKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQD
FT ILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNH
FT GLVWLSAAMGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS -> SES
FT CPRAPKEPAPLKTPLQWGISSQEPAVCLSFQLIQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037309"
FT CONFLICT 360
FT /note="I -> T (in Ref. 1; AAQ88739)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 50490 MW; BF3DE7C742C685CE CRC64;
MLHPETSPGR GHLLAVLLAL LGTTWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS
WVQPPAADMR RLDWSDSLAQ LAQARAALCG IPTPSLASGL WRTLQVGWNM QLLPAGLASF
VEVVSLWFAE GQRYSHAAGE CARNATCTHY TQLVWATSSQ LGCGRHLCSA GQTAIEAFVC
AYSPGGNWEV NGKTIIPYKK GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG
RLNISTCHCH CPPGYTGRYC QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH
TCDLRIDGDC FMVSSEADTY YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI
DSDFETRNFW IGLTYKTAKD SFRWATGEHQ AFTSFAFGQP DNHGLVWLSA AMGFGNCVEL
QASAAFNWND QRCKTRNRYI CQFAQEHISR WGPGS
